Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184906144> ?p ?o ?g. }
- W3184906144 endingPage "876" @default.
- W3184906144 startingPage "876" @default.
- W3184906144 abstract "Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer associated with a high rate of metastasis, poor prognosis, and lack of therapeutic targets. Although target-based therapeutic options are approved for other cancers, only limited therapeutic options are available for TNBC. Cell signaling and receptor-specific targets are reportedly effective in patients with TNBC under specific clinical conditions. However, most of these cancers are unresponsive, and there is a requirement for more effective treatment modalities. Further, there is a lack of effective biomarkers that can distinguish TNBC from other BC subtypes. ER, PR, and HER2 help identify TNBC and are widely used to identify patients who are most likely to respond to diverse therapeutic strategies. In this review, we discuss the possible treatment options for TNBC based on its inherent subtype receptors and pathways, such as p53 signaling, AKT signaling, cell cycle regulation, DNA damage, and programmed cell death, which play essential roles at multiple stages of TNBC development. We focus on poly-ADP ribose polymerase 1, androgen receptor, vascular endothelial growth factor receptor, and epidermal growth factor receptor as well as the application of nanomedicine and immunotherapy in TNBC and discuss their potential applications in drug development for TNBC." @default.
- W3184906144 created "2021-08-02" @default.
- W3184906144 creator A5055609480 @default.
- W3184906144 creator A5078385831 @default.
- W3184906144 date "2021-07-23" @default.
- W3184906144 modified "2023-10-16" @default.
- W3184906144 title "TNBC: Potential Targeting of Multiple Receptors for a Therapeutic Breakthrough, Nanomedicine, and Immunotherapy" @default.
- W3184906144 cites W1758612015 @default.
- W3184906144 cites W1965914619 @default.
- W3184906144 cites W1966390946 @default.
- W3184906144 cites W1972245883 @default.
- W3184906144 cites W1987696692 @default.
- W3184906144 cites W2003336829 @default.
- W3184906144 cites W2032760352 @default.
- W3184906144 cites W2033624169 @default.
- W3184906144 cites W2040812935 @default.
- W3184906144 cites W2096745115 @default.
- W3184906144 cites W2108583660 @default.
- W3184906144 cites W2123107246 @default.
- W3184906144 cites W2128777602 @default.
- W3184906144 cites W2131340972 @default.
- W3184906144 cites W2143713582 @default.
- W3184906144 cites W2153769134 @default.
- W3184906144 cites W2160730562 @default.
- W3184906144 cites W2165047644 @default.
- W3184906144 cites W2174687263 @default.
- W3184906144 cites W2279794760 @default.
- W3184906144 cites W2341689934 @default.
- W3184906144 cites W2403389346 @default.
- W3184906144 cites W2415978549 @default.
- W3184906144 cites W2484150980 @default.
- W3184906144 cites W2542081802 @default.
- W3184906144 cites W2562126198 @default.
- W3184906144 cites W2592710921 @default.
- W3184906144 cites W2734462584 @default.
- W3184906144 cites W2743639018 @default.
- W3184906144 cites W2747016053 @default.
- W3184906144 cites W2749338586 @default.
- W3184906144 cites W2756868900 @default.
- W3184906144 cites W2765386661 @default.
- W3184906144 cites W2775645637 @default.
- W3184906144 cites W2783552773 @default.
- W3184906144 cites W2787415149 @default.
- W3184906144 cites W2795063553 @default.
- W3184906144 cites W2797537475 @default.
- W3184906144 cites W2799820786 @default.
- W3184906144 cites W2801658413 @default.
- W3184906144 cites W2809205318 @default.
- W3184906144 cites W2886477543 @default.
- W3184906144 cites W2886945890 @default.
- W3184906144 cites W2887812103 @default.
- W3184906144 cites W2889746019 @default.
- W3184906144 cites W2890564758 @default.
- W3184906144 cites W2902655481 @default.
- W3184906144 cites W2903175024 @default.
- W3184906144 cites W2913584903 @default.
- W3184906144 cites W2923648632 @default.
- W3184906144 cites W2930305328 @default.
- W3184906144 cites W2945898602 @default.
- W3184906144 cites W2949217529 @default.
- W3184906144 cites W2952188907 @default.
- W3184906144 cites W2954948308 @default.
- W3184906144 cites W2955872001 @default.
- W3184906144 cites W2960583787 @default.
- W3184906144 cites W2967434552 @default.
- W3184906144 cites W2969263349 @default.
- W3184906144 cites W2969782175 @default.
- W3184906144 cites W2972270957 @default.
- W3184906144 cites W2972627485 @default.
- W3184906144 cites W2978539957 @default.
- W3184906144 cites W2979272694 @default.
- W3184906144 cites W2980207380 @default.
- W3184906144 cites W2981115842 @default.
- W3184906144 cites W2981815989 @default.
- W3184906144 cites W2982411421 @default.
- W3184906144 cites W2982514238 @default.
- W3184906144 cites W2984927918 @default.
- W3184906144 cites W2993536313 @default.
- W3184906144 cites W2995571090 @default.
- W3184906144 cites W2996625978 @default.
- W3184906144 cites W2998673728 @default.
- W3184906144 cites W2999567885 @default.
- W3184906144 cites W3000361261 @default.
- W3184906144 cites W3001096019 @default.
- W3184906144 cites W3003627105 @default.
- W3184906144 cites W3006189910 @default.
- W3184906144 cites W3006930853 @default.
- W3184906144 cites W3010125065 @default.
- W3184906144 cites W3010171804 @default.
- W3184906144 cites W3010714596 @default.
- W3184906144 cites W3012389413 @default.
- W3184906144 cites W3013898070 @default.
- W3184906144 cites W3014103094 @default.
- W3184906144 cites W3014583893 @default.
- W3184906144 cites W3014599323 @default.
- W3184906144 cites W3014768524 @default.
- W3184906144 cites W3016191869 @default.
- W3184906144 cites W3020484084 @default.