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- W3184933268 abstract "Phytochemical screening of the crude n-BuOH fraction of MeOH extract of the aerial parts of Neanotis wightiana (family Rubiaceae) to find out the bioactive principles and resulting in the isolation, purification and characterization of a new bioactive naphthalene glucoside, named as Neanoside D by column chromatography through silica gel. The structure of Neanoside D was elucidated as 1,4-dihydroxy-2-(6'-O-methylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by extensive spectroscopic analysis, including HR-MS, 2D NMR and the comparison of literature data. Neanoside D was further subjected to screening for in vitro anticancer activity using MTT based cytotoxicity assay, LDH leakage assay and estimation of intracellular ROS production in two human breast cancer cell lines and exhibited significant activity with concentration dependent intracellular LDH leakage and ROS production. Hence, Neanoside D may be projected for further study toward development of anticancer lead molecule for breast cancer therapy." @default.
- W3184933268 created "2021-08-02" @default.
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- W3184933268 date "2020-02-07" @default.
- W3184933268 modified "2023-09-25" @default.
- W3184933268 title "Bio-Active Naphthalene Glucoside From Neanotis Wightiana" @default.
- W3184933268 hasPublicationYear "2020" @default.
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