Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184953669> ?p ?o ?g. }
- W3184953669 endingPage "1157" @default.
- W3184953669 startingPage "1157" @default.
- W3184953669 abstract "The liver is a key metabolic organ that is particularly sensitive to environmental factors, including UV radiation. As UV radiation induces oxidative stress and inflammation, natural compounds are under investigation as one method to counteract these consequences. The aim of this study was to assess the effect of topical application of phytocannabinoid-cannabidiol (CBD) on the skin of nude rats chronically irradiated with UVA/UVB, paying particular attention to its impact on the liver antioxidants and phospholipid metabolism. The results of this study indicate that CBD reaches the rat liver where it is then metabolized into decarbonylated cannabidiol, 7-hydroxy-cannabidiol and cannabidiol-glucuronide. CBD increased the levels of GSH and vitamin A after UVB radiation. Moreover, CBD prevents the increase of 4-hydroxynonenal and 8-iso-prostaglandin-F2α levels in UVA-irradiated rats. As a consequence of reductions in phospholipase A2 and cyclooxygenases activity following UV irradiation, CBD upregulates the level of 2-arachidonoylglycerol and downregulates prostaglandin E2 and leukotriene B4. Finally, CBD enhances decreased level of 15-deoxy-Δ-12,14-prostaglandin J2 after UVB radiation and 15-hydroxyeicosatetraenoic acid after UVA radiation. These data show that CBD applied to the skin prevents ROS- and enzyme-dependent phospholipid metabolism in the liver of UV-irradiated rats, suggesting that it may be used as an internal organ protector." @default.
- W3184953669 created "2021-08-02" @default.
- W3184953669 creator A5036773939 @default.
- W3184953669 creator A5045227473 @default.
- W3184953669 creator A5047071423 @default.
- W3184953669 date "2021-07-21" @default.
- W3184953669 modified "2023-09-23" @default.
- W3184953669 title "Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol" @default.
- W3184953669 cites W1166458116 @default.
- W3184953669 cites W1625092822 @default.
- W3184953669 cites W1757834753 @default.
- W3184953669 cites W1774869653 @default.
- W3184953669 cites W1872022504 @default.
- W3184953669 cites W191109327 @default.
- W3184953669 cites W191793640 @default.
- W3184953669 cites W1972368094 @default.
- W3184953669 cites W1978804708 @default.
- W3184953669 cites W1986706355 @default.
- W3184953669 cites W1997062461 @default.
- W3184953669 cites W2012080142 @default.
- W3184953669 cites W2014503546 @default.
- W3184953669 cites W2014896840 @default.
- W3184953669 cites W2016356853 @default.
- W3184953669 cites W2023622978 @default.
- W3184953669 cites W2028723042 @default.
- W3184953669 cites W2044384443 @default.
- W3184953669 cites W2044927265 @default.
- W3184953669 cites W2049966881 @default.
- W3184953669 cites W2050010956 @default.
- W3184953669 cites W2051176148 @default.
- W3184953669 cites W2051762105 @default.
- W3184953669 cites W2065020384 @default.
- W3184953669 cites W2066839216 @default.
- W3184953669 cites W2074128028 @default.
- W3184953669 cites W2074888698 @default.
- W3184953669 cites W2088639506 @default.
- W3184953669 cites W2092105733 @default.
- W3184953669 cites W2096468584 @default.
- W3184953669 cites W2119137906 @default.
- W3184953669 cites W2119898593 @default.
- W3184953669 cites W2127220842 @default.
- W3184953669 cites W2128473487 @default.
- W3184953669 cites W2130768392 @default.
- W3184953669 cites W2134598408 @default.
- W3184953669 cites W2137597300 @default.
- W3184953669 cites W2143741723 @default.
- W3184953669 cites W2153400793 @default.
- W3184953669 cites W2166806732 @default.
- W3184953669 cites W2167249487 @default.
- W3184953669 cites W2309274031 @default.
- W3184953669 cites W2505732415 @default.
- W3184953669 cites W2535762306 @default.
- W3184953669 cites W2542105425 @default.
- W3184953669 cites W2553262419 @default.
- W3184953669 cites W2736655086 @default.
- W3184953669 cites W2755574346 @default.
- W3184953669 cites W2756343284 @default.
- W3184953669 cites W2793621612 @default.
- W3184953669 cites W2797565625 @default.
- W3184953669 cites W2884052855 @default.
- W3184953669 cites W2891473083 @default.
- W3184953669 cites W2899384460 @default.
- W3184953669 cites W2912305434 @default.
- W3184953669 cites W2916674868 @default.
- W3184953669 cites W2918761870 @default.
- W3184953669 cites W2919002166 @default.
- W3184953669 cites W2943858072 @default.
- W3184953669 cites W2944970479 @default.
- W3184953669 cites W2998014803 @default.
- W3184953669 cites W3010332627 @default.
- W3184953669 cites W3011459724 @default.
- W3184953669 cites W3019420656 @default.
- W3184953669 cites W3033467413 @default.
- W3184953669 cites W3033722746 @default.
- W3184953669 cites W3034942882 @default.
- W3184953669 cites W3037033162 @default.
- W3184953669 cites W3039772549 @default.
- W3184953669 cites W3041851319 @default.
- W3184953669 cites W3042736690 @default.
- W3184953669 cites W3086271615 @default.
- W3184953669 cites W3086667656 @default.
- W3184953669 cites W3089245332 @default.
- W3184953669 cites W3093246735 @default.
- W3184953669 cites W3132783681 @default.
- W3184953669 cites W3144843933 @default.
- W3184953669 cites W3160327629 @default.
- W3184953669 cites W3163467116 @default.
- W3184953669 doi "https://doi.org/10.3390/antiox10081157" @default.
- W3184953669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8388943" @default.
- W3184953669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34439405" @default.
- W3184953669 hasPublicationYear "2021" @default.
- W3184953669 type Work @default.
- W3184953669 sameAs 3184953669 @default.
- W3184953669 citedByCount "6" @default.
- W3184953669 countsByYear W31849536692021 @default.
- W3184953669 countsByYear W31849536692022 @default.
- W3184953669 countsByYear W31849536692023 @default.
- W3184953669 crossrefType "journal-article" @default.