FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184965186> ?p ?o ?g. }

• W3184965186 endingPage "1029" @default.
• W3184965186 startingPage "1022" @default.
• W3184965186 abstract "To investigate whether miR-let-7c-5p inhibits invasion and migration of bladder cancer cells by regulating HMGA2.We used bioinformatics methods to determine the key genes of miR-let-7c-5p. RT-qPCR and Western blotting were used to detect the expressions of miR-let-7c-5p mRNA and HMGA2 protein in bladder cancer and adjacent tissues. With human normal bladder SV-HUC-1 cells as the control, we detected the expression levels of miR-let-7c-5p mRNA and HMGA2 protein in bladder cancer cell lines T24, UM-UC-3 and 5637 with RT-qPCR and Western blotting. We observed the effects of miR-let-7c-5p upregulation (by transfection with a miR-let-7c-5p mimic), miR-let-7c-5p downregulation (using a miR-let-7c-5p inhibitor), and knockdown of both HMGA2 and miR-let-7c-5p on invasion, migration and expressions of epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, N-cadherin, vimentin, and Snail) in UM-UC-3 cells. Dual luciferase assay, RT-qPCR and Western blotting were used to verify the targeting relationship between miR-let-7c-5p and HMGA2.HMGA2 was identified as one of the target genes of miR-let-7c-5p. Compared with the adjacent tissues, bladder cancer tissues showed a significantly decreased expression of miR-let-7c-5p and an increased expression of HMGA2 protein (P < 0.05). In UM-UC-3 cells, the expression of miR-let-7c-5p was significantly reduced and that of HMGA2 was significantly increased as compared with those in SV-HUC-1 cells (P=0.001). Up-regulating miR-let-7c-5p expression significantly lowered the invasion and migration abilities of UM-UC-3 cells, and down-regulating miR-let-7c-5p expression obviously promoted the invasion and migration of UM-UC-3 cells (P < 0.05). Knockdown of both miR-let-7c-5p and HMGA2 expression significantly lowered the invasion and migration (P < 0.05) and inhibited the expressions of EMT-related proteins of UM-UC-3 cells (P < 0.05).miR-let-7c-5p inhibits EMT of bladder cancer UM-UC-3 cells by targeting HMGA2, thereby inhibiting the cell invasion and migration." @default.
• W3184965186 created "2021-08-02" @default.
• W3184965186 creator A5015736247 @default.
• W3184965186 creator A5022803653 @default.
• W3184965186 creator A5030852102 @default.
• W3184965186 creator A5031188584 @default.
• W3184965186 creator A5039368280 @default.
• W3184965186 creator A5090794744 @default.
• W3184965186 date "2021-07-20" @default.
• W3184965186 modified "2023-09-26" @default.
• W3184965186 title "[miR-let-7c-5p inhibits invasion and migration of bladder cancer cells by targeting HMGA2]." @default.
• W3184965186 cites W1945007132 @default.
• W3184965186 cites W1971204432 @default.
• W3184965186 cites W2135411716 @default.
• W3184965186 cites W2142489285 @default.
• W3184965186 cites W2191676373 @default.
• W3184965186 cites W2301647511 @default.
• W3184965186 cites W2410400328 @default.
• W3184965186 cites W2462649057 @default.
• W3184965186 cites W2471785477 @default.
• W3184965186 cites W2737295092 @default.
• W3184965186 cites W2801475086 @default.
• W3184965186 cites W2803068624 @default.
• W3184965186 cites W2891743995 @default.
• W3184965186 cites W2942626650 @default.
• W3184965186 cites W2947198834 @default.
• W3184965186 cites W2952986952 @default.
• W3184965186 cites W2953437798 @default.
• W3184965186 cites W2954959909 @default.
• W3184965186 cites W2975098078 @default.
• W3184965186 cites W2989225794 @default.
• W3184965186 cites W2995404049 @default.
• W3184965186 cites W3000217015 @default.
• W3184965186 cites W3006312440 @default.
• W3184965186 cites W3012599879 @default.
• W3184965186 cites W3016341670 @default.
• W3184965186 cites W3020540847 @default.
• W3184965186 cites W3029873756 @default.
• W3184965186 cites W3097518376 @default.
• W3184965186 cites W3111214915 @default.
• W3184965186 cites W3114657782 @default.
• W3184965186 cites W3122015858 @default.
• W3184965186 doi "https://doi.org/10.12122/j.issn.1673-4254.2021.07.08" @default.
• W3184965186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8329690" @default.
• W3184965186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34308851" @default.
• W3184965186 hasPublicationYear "2021" @default.
• W3184965186 type Work @default.
• W3184965186 sameAs 3184965186 @default.
• W3184965186 citedByCount "1" @default.
• W3184965186 countsByYear W31849651862022 @default.
• W3184965186 crossrefType "journal-article" @default.
• W3184965186 hasAuthorship W3184965186A5015736247 @default.
• W3184965186 hasAuthorship W3184965186A5022803653 @default.
• W3184965186 hasAuthorship W3184965186A5030852102 @default.
• W3184965186 hasAuthorship W3184965186A5031188584 @default.
• W3184965186 hasAuthorship W3184965186A5039368280 @default.
• W3184965186 hasAuthorship W3184965186A5090794744 @default.
• W3184965186 hasConcept C104317684 @default.
• W3184965186 hasConcept C105580179 @default.
• W3184965186 hasConcept C121608353 @default.
• W3184965186 hasConcept C127561419 @default.
• W3184965186 hasConcept C145059251 @default.
• W3184965186 hasConcept C147447768 @default.
• W3184965186 hasConcept C153911025 @default.
• W3184965186 hasConcept C173396325 @default.
• W3184965186 hasConcept C203014093 @default.
• W3184965186 hasConcept C204232928 @default.
• W3184965186 hasConcept C2529059 @default.
• W3184965186 hasConcept C2780352672 @default.
• W3184965186 hasConcept C502942594 @default.
• W3184965186 hasConcept C54009773 @default.
• W3184965186 hasConcept C54355233 @default.
• W3184965186 hasConcept C76419328 @default.
• W3184965186 hasConcept C81885089 @default.
• W3184965186 hasConcept C85265743 @default.
• W3184965186 hasConcept C86803240 @default.
• W3184965186 hasConceptScore W3184965186C104317684 @default.
• W3184965186 hasConceptScore W3184965186C105580179 @default.
• W3184965186 hasConceptScore W3184965186C121608353 @default.
• W3184965186 hasConceptScore W3184965186C127561419 @default.
• W3184965186 hasConceptScore W3184965186C145059251 @default.
• W3184965186 hasConceptScore W3184965186C147447768 @default.
• W3184965186 hasConceptScore W3184965186C153911025 @default.
• W3184965186 hasConceptScore W3184965186C173396325 @default.
• W3184965186 hasConceptScore W3184965186C203014093 @default.
• W3184965186 hasConceptScore W3184965186C204232928 @default.
• W3184965186 hasConceptScore W3184965186C2529059 @default.
• W3184965186 hasConceptScore W3184965186C2780352672 @default.
• W3184965186 hasConceptScore W3184965186C502942594 @default.
• W3184965186 hasConceptScore W3184965186C54009773 @default.
• W3184965186 hasConceptScore W3184965186C54355233 @default.
• W3184965186 hasConceptScore W3184965186C76419328 @default.
• W3184965186 hasConceptScore W3184965186C81885089 @default.
• W3184965186 hasConceptScore W3184965186C85265743 @default.
• W3184965186 hasConceptScore W3184965186C86803240 @default.
• W3184965186 hasIssue "7" @default.
• W3184965186 hasLocation W31849651861 @default.
• W3184965186 hasOpenAccess W3184965186 @default.

• next