Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184990103> ?p ?o ?g. }
- W3184990103 endingPage "1185" @default.
- W3184990103 startingPage "1174" @default.
- W3184990103 abstract "The long-term safety and effectiveness of bronchoscopic lung volume reduction with Zephyr endobronchial valves in subjects with severe homogeneous emphysema with little to no collateral ventilation beyond 3 months have yet to be established.Ninety-three subjects were randomized to either bronchoscopic lung volume reduction with Zephyr valves or standard of care (SoC) (1:1). Zephyr valve subjects were assessed at 3, 6, and 12 months. SoC subjects were assessed at 3 and 6 months; they were then offered crossover to Zephyr valve treatment.The mean group difference (Zephyr valve - SoC) for change in FEV1 from baseline to 6 months was 16.3 ± 22.1% (mean ± SD; p < 0.001). Secondary outcomes showed the mean between-group difference for the six-minute walk distance of +28.3 ± 55.3 m (p = 0.016); St. George's Respiratory Questionnaire, -7.51 ± 9.56 points (p < 0.001); modified Medical Research Council, -0.42 ± 0.81 points (p = 0.019); BODE index, -0.85 ± 1.39 points (p = 0.006); and residual volume of -430 ± 830 mL (p = 0.011) in favor of the Zephyr valve group. At 6 months, there were significantly more responders based on the minimal clinically important difference for these same measures in the Zephyr valve versus the SoC group. The clinical benefits were persistent at 12 months. The percentage of subjects with respiratory serious adverse events was higher in the Zephyr valve group compared to SoC during the first 30 days post-procedure but not statistically different for the Zephyr valve and SoC groups from 31 days to 6 months, and stable in the Zephyr valve group out to 12 months. There were 2 deaths in the SoC group in the 31-day to 6-month period and none in the Zephyr valve group out to 12 months.Bronchoscopic lung volume reduction with Zephyr valves in subjects with severe homogeneous emphysema and little to no collateral ventilation provides clinically meaningful change from baseline in lung function, quality of life, exercise capacity, dyspnea, and the BODE index at 6 months, with benefits maintained out to 12 months." @default.
- W3184990103 created "2021-08-02" @default.
- W3184990103 creator A5000140641 @default.
- W3184990103 creator A5011149495 @default.
- W3184990103 creator A5016728677 @default.
- W3184990103 creator A5021853115 @default.
- W3184990103 creator A5024585720 @default.
- W3184990103 creator A5040262431 @default.
- W3184990103 creator A5049214781 @default.
- W3184990103 creator A5049580272 @default.
- W3184990103 creator A5059197293 @default.
- W3184990103 creator A5082059315 @default.
- W3184990103 creator A5083977247 @default.
- W3184990103 creator A5085824694 @default.
- W3184990103 date "2021-01-01" @default.
- W3184990103 modified "2023-10-01" @default.
- W3184990103 title "Endobronchial Valve (Zephyr) Treatment in Homogeneous Emphysema: One-Year Results from the IMPACT Randomized Clinical Trial" @default.
- W3184990103 cites W1684699171 @default.
- W3184990103 cites W1691036297 @default.
- W3184990103 cites W1870141733 @default.
- W3184990103 cites W1996198438 @default.
- W3184990103 cites W2078446222 @default.
- W3184990103 cites W2082549665 @default.
- W3184990103 cites W2100907959 @default.
- W3184990103 cites W2101787490 @default.
- W3184990103 cites W2111374619 @default.
- W3184990103 cites W2117786052 @default.
- W3184990103 cites W2227775770 @default.
- W3184990103 cites W2363935454 @default.
- W3184990103 cites W2411862734 @default.
- W3184990103 cites W2413995426 @default.
- W3184990103 cites W2507196609 @default.
- W3184990103 cites W2562519877 @default.
- W3184990103 cites W2567054886 @default.
- W3184990103 cites W2605650619 @default.
- W3184990103 cites W2750937879 @default.
- W3184990103 cites W2785216066 @default.
- W3184990103 doi "https://doi.org/10.1159/000517034" @default.
- W3184990103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34350884" @default.
- W3184990103 hasPublicationYear "2021" @default.
- W3184990103 type Work @default.
- W3184990103 sameAs 3184990103 @default.
- W3184990103 citedByCount "5" @default.
- W3184990103 countsByYear W31849901032022 @default.
- W3184990103 countsByYear W31849901032023 @default.
- W3184990103 crossrefType "journal-article" @default.
- W3184990103 hasAuthorship W3184990103A5000140641 @default.
- W3184990103 hasAuthorship W3184990103A5011149495 @default.
- W3184990103 hasAuthorship W3184990103A5016728677 @default.
- W3184990103 hasAuthorship W3184990103A5021853115 @default.
- W3184990103 hasAuthorship W3184990103A5024585720 @default.
- W3184990103 hasAuthorship W3184990103A5040262431 @default.
- W3184990103 hasAuthorship W3184990103A5049214781 @default.
- W3184990103 hasAuthorship W3184990103A5049580272 @default.
- W3184990103 hasAuthorship W3184990103A5059197293 @default.
- W3184990103 hasAuthorship W3184990103A5082059315 @default.
- W3184990103 hasAuthorship W3184990103A5083977247 @default.
- W3184990103 hasAuthorship W3184990103A5085824694 @default.
- W3184990103 hasBestOaLocation W31849901031 @default.
- W3184990103 hasConcept C121332964 @default.
- W3184990103 hasConcept C126322002 @default.
- W3184990103 hasConcept C168563851 @default.
- W3184990103 hasConcept C197934379 @default.
- W3184990103 hasConcept C2777714996 @default.
- W3184990103 hasConcept C2910422816 @default.
- W3184990103 hasConcept C42219234 @default.
- W3184990103 hasConcept C66882249 @default.
- W3184990103 hasConcept C71924100 @default.
- W3184990103 hasConcept C97355855 @default.
- W3184990103 hasConceptScore W3184990103C121332964 @default.
- W3184990103 hasConceptScore W3184990103C126322002 @default.
- W3184990103 hasConceptScore W3184990103C168563851 @default.
- W3184990103 hasConceptScore W3184990103C197934379 @default.
- W3184990103 hasConceptScore W3184990103C2777714996 @default.
- W3184990103 hasConceptScore W3184990103C2910422816 @default.
- W3184990103 hasConceptScore W3184990103C42219234 @default.
- W3184990103 hasConceptScore W3184990103C66882249 @default.
- W3184990103 hasConceptScore W3184990103C71924100 @default.
- W3184990103 hasConceptScore W3184990103C97355855 @default.
- W3184990103 hasIssue "12" @default.
- W3184990103 hasLocation W31849901031 @default.
- W3184990103 hasLocation W31849901032 @default.
- W3184990103 hasLocation W31849901033 @default.
- W3184990103 hasLocation W31849901034 @default.
- W3184990103 hasLocation W31849901035 @default.
- W3184990103 hasOpenAccess W3184990103 @default.
- W3184990103 hasPrimaryLocation W31849901031 @default.
- W3184990103 hasRelatedWork W2154895014 @default.
- W3184990103 hasRelatedWork W2296306650 @default.
- W3184990103 hasRelatedWork W2787209802 @default.
- W3184990103 hasRelatedWork W2895574899 @default.
- W3184990103 hasRelatedWork W3159250744 @default.
- W3184990103 hasRelatedWork W4221091279 @default.
- W3184990103 hasRelatedWork W4256514411 @default.
- W3184990103 hasRelatedWork W4292236216 @default.
- W3184990103 hasRelatedWork W4311289911 @default.
- W3184990103 hasRelatedWork W2083697902 @default.
- W3184990103 hasVolume "100" @default.