FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185081337> ?p ?o ?g. }

• W3185081337 abstract "Excessive mucus production is a major feature of allergic asthma. Disruption of epithelial junctions by allergens such as house dust mite (HDM) results in the activation of β-catenin signaling, which has been reported to stimulate goblet cell differentiation. β-catenin interacts with various co-activators including CREB binding protein (CBP) and p300, thereby regulating the expression of genes involved in cell proliferation and differentiation, respectively. We specifically investigated the role of the β-catenin/CBP signaling pathway in goblet cell metaplasia in a HDM-induced allergic airway disease model in mice using ICG-001, a small molecule inhibitor that blocks the binding of CBP to β-catenin. Female 6- 8-week-old BALB/c mice were sensitized to HDM/saline on days 0, 1, and 2, followed by intranasal challenge with HDM/saline with or without subcutaneous ICG-001/vehicle treatment from days 14 to 17, and samples harvested 24 h after the last challenge/treatment. Differential inflammatory cells in bronchoalveolar lavage (BAL) fluid were enumerated. Alcian blue (AB)/Periodic acid–Schiff (PAS) staining was used to identify goblet cells/mucus production, and airway hyperresponsiveness (AHR) was assessed using invasive plethysmography. Exposure to HDM induced airway inflammation, goblet cell metaplasia and increased AHR, with increased airway resistance in response to the non-specific spasmogen methacholine. Inhibition of the β-catenin/CBP pathway using treatment with ICG-001 significantly attenuated the HDM-induced goblet cell metaplasia and infiltration of macrophages, but had no effect on eosinophils, neutrophils, lymphocytes or AHR. Increased β-catenin/CBP signaling may promote HDM-induced goblet cell metaplasia in mice." @default.
• W3185081337 created "2021-08-02" @default.
• W3185081337 creator A5005383444 @default.
• W3185081337 creator A5024463990 @default.
• W3185081337 creator A5026882361 @default.
• W3185081337 creator A5030526109 @default.
• W3185081337 creator A5056502030 @default.
• W3185081337 creator A5068260529 @default.
• W3185081337 creator A5086600671 @default.
• W3185081337 date "2021-07-27" @default.
• W3185081337 modified "2023-10-01" @default.
• W3185081337 title "Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice" @default.
• W3185081337 cites W1264906715 @default.
• W3185081337 cites W1586150156 @default.
• W3185081337 cites W1830269738 @default.
• W3185081337 cites W1924842828 @default.
• W3185081337 cites W1966365711 @default.
• W3185081337 cites W1972212921 @default.
• W3185081337 cites W2003176984 @default.
• W3185081337 cites W2022928437 @default.
• W3185081337 cites W2041905009 @default.
• W3185081337 cites W2042049199 @default.
• W3185081337 cites W2055685990 @default.
• W3185081337 cites W2056801328 @default.
• W3185081337 cites W2062721883 @default.
• W3185081337 cites W2074320193 @default.
• W3185081337 cites W2076282316 @default.
• W3185081337 cites W2076381752 @default.
• W3185081337 cites W2082848636 @default.
• W3185081337 cites W2103010372 @default.
• W3185081337 cites W2103585613 @default.
• W3185081337 cites W2114570899 @default.
• W3185081337 cites W2115001053 @default.
• W3185081337 cites W2121856873 @default.
• W3185081337 cites W2129296802 @default.
• W3185081337 cites W2132448663 @default.
• W3185081337 cites W2144796426 @default.
• W3185081337 cites W2152366177 @default.
• W3185081337 cites W2161593731 @default.
• W3185081337 cites W2164473032 @default.
• W3185081337 cites W2166745068 @default.
• W3185081337 cites W2412707497 @default.
• W3185081337 cites W2519605039 @default.
• W3185081337 cites W2586282709 @default.
• W3185081337 cites W2592360437 @default.
• W3185081337 cites W2593240146 @default.
• W3185081337 cites W2751285788 @default.
• W3185081337 cites W2765851819 @default.
• W3185081337 cites W2781460303 @default.
• W3185081337 cites W2889297418 @default.
• W3185081337 cites W2889523198 @default.
• W3185081337 cites W2909050129 @default.
• W3185081337 cites W2950891712 @default.
• W3185081337 cites W3000186698 @default.
• W3185081337 cites W3004860552 @default.
• W3185081337 cites W769303411 @default.
• W3185081337 doi "https://doi.org/10.3389/fphys.2021.690531" @default.
• W3185081337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8353457" @default.
• W3185081337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34385933" @default.
• W3185081337 hasPublicationYear "2021" @default.
• W3185081337 type Work @default.
• W3185081337 sameAs 3185081337 @default.
• W3185081337 citedByCount "1" @default.
• W3185081337 countsByYear W31850813372022 @default.
• W3185081337 crossrefType "journal-article" @default.
• W3185081337 hasAuthorship W3185081337A5005383444 @default.
• W3185081337 hasAuthorship W3185081337A5024463990 @default.
• W3185081337 hasAuthorship W3185081337A5026882361 @default.
• W3185081337 hasAuthorship W3185081337A5030526109 @default.
• W3185081337 hasAuthorship W3185081337A5056502030 @default.
• W3185081337 hasAuthorship W3185081337A5068260529 @default.
• W3185081337 hasAuthorship W3185081337A5086600671 @default.
• W3185081337 hasBestOaLocation W31850813371 @default.
• W3185081337 hasConcept C126322002 @default.
• W3185081337 hasConcept C141105273 @default.
• W3185081337 hasConcept C142724271 @default.
• W3185081337 hasConcept C159654299 @default.
• W3185081337 hasConcept C179264091 @default.
• W3185081337 hasConcept C18903297 @default.
• W3185081337 hasConcept C203014093 @default.
• W3185081337 hasConcept C2775941134 @default.
• W3185081337 hasConcept C2776042228 @default.
• W3185081337 hasConcept C2777037409 @default.
• W3185081337 hasConcept C2777312293 @default.
• W3185081337 hasConcept C2778166374 @default.
• W3185081337 hasConcept C2778981785 @default.
• W3185081337 hasConcept C2779357193 @default.
• W3185081337 hasConcept C529295009 @default.
• W3185081337 hasConcept C71924100 @default.
• W3185081337 hasConcept C86803240 @default.
• W3185081337 hasConcept C87568996 @default.
• W3185081337 hasConceptScore W3185081337C126322002 @default.
• W3185081337 hasConceptScore W3185081337C141105273 @default.
• W3185081337 hasConceptScore W3185081337C142724271 @default.
• W3185081337 hasConceptScore W3185081337C159654299 @default.
• W3185081337 hasConceptScore W3185081337C179264091 @default.
• W3185081337 hasConceptScore W3185081337C18903297 @default.
• W3185081337 hasConceptScore W3185081337C203014093 @default.
• W3185081337 hasConceptScore W3185081337C2775941134 @default.
• W3185081337 hasConceptScore W3185081337C2776042228 @default.

• next