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• W3185161880 endingPage "1549" @default.
• W3185161880 startingPage "1549" @default.
• W3185161880 abstract "Mathematical models are becoming increasingly important in magnetic resonance imaging (MRI), as they provide a mechanistic approach for making a link between tissue microstructure and signals acquired using the medical imaging instrument. The Bloch equations, which describes spin and relaxation in a magnetic field, are a set of integer order differential equations with a solution exhibiting mono-exponential behaviour in time. Parameters of the model may be estimated using a non-linear solver or by creating a dictionary of model parameters from which MRI signals are simulated and then matched with experiment. We have previously shown the potential efficacy of a magnetic resonance fingerprinting (MRF) approach, i.e., dictionary matching based on the classical Bloch equations for parcellating the human cerebral cortex. However, this classical model is unable to describe in full the mm-scale MRI signal generated based on an heterogenous and complex tissue micro-environment. The time-fractional order Bloch equations have been shown to provide, as a function of time, a good fit of brain MRI signals. The time-fractional model has solutions in the form of Mittag–Leffler functions that generalise conventional exponential relaxation. Such functions have been shown by others to be useful for describing dielectric and viscoelastic relaxation in complex heterogeneous materials. Hence, we replaced the integer order Bloch equations with the previously reported time-fractional counterpart within the MRF framework and performed experiments to parcellate human gray matter, which consists of cortical brain tissue with different cyto-architecture at different spatial locations. Our findings suggest that the time-fractional order parameters, α and β, potentially associate with the effect of interareal architectonic variability, which hypothetically results in more accurate cortical parcellation." @default.
• W3185161880 created "2021-08-02" @default.
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• W3185161880 date "2021-07-01" @default.
• W3185161880 modified "2023-10-17" @default.
• W3185161880 title "Fractional Order Magnetic Resonance Fingerprinting in the Human Cerebral Cortex" @default.
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• W3185161880 doi "https://doi.org/10.3390/math9131549" @default.
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