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• W3185252607 abstract "• Neurofilament light (NfL) elevated in MCI patients who converted to AD. • CSF NfL elevated with MMSE score in control, MCI and AD individuals. • CSF NfL was correlated with AD-related biomarkers of CSF amyloid and tau. • NfL may be useful for predicting AD conversion. Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = 52), amnestic mild cognitive impairment (aMCI) (n = 55), and probable AD dementia (n = 28) individuals. The cohort was reevaluated after 6-10 years. Baseline CSF NfL was significantly elevated in aMCI and probable AD dementia groups compared to controls ( p < 0.0001). CSF NfL was significantly lower in stable aMCI patients compared to aMCI patients who converted to probable AD dementia within the 24-month period ( p = 0.004). Substituting T-tau for NfL in the core AD biomarkers model (Aβ42/P-tau/T-tau) did not improve ability to separate control and AD, or stable and converter aMCI patients. Our results support that elevated CSF NfL could predict progression in aMCI patients, but its utility cannot improve the core AD biomarkers." @default.
• W3185252607 created "2021-08-02" @default.
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• W3185252607 date "2021-11-01" @default.
• W3185252607 modified "2023-09-26" @default.
• W3185252607 title "CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia" @default.
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• W3185252607 doi "https://doi.org/10.1016/j.neurobiolaging.2021.07.013" @default.
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