FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185265447> ?p ?o ?g. }

• W3185265447 abstract "Background: Combined antiretroviral therapy (cART) has been associated with a steep decrease in mortality and morbidity in HIV-1 infected children. New antiretroviral molecules and drug classes have been developed and the management of HIV-infected children has improved, but recent data on survival are limited. Methods: An observational retrospective study investigating changes in mortality and morbidity was conducted on 1,091 perinatally HIV-1 infected children enrolled in the Italian Register for HIV Infection in Children and followed-up from 2001 to 2018. Results: Three hundred and fifty-four (32%) AIDS events and 26 (2%) deaths occurred overtime. Mortality rates decreased from 0.4/100 person-years in 2001–2006 to 0.27/100 person-years in 2007–2012 and 0.07/100 person-years in 2013–2018. Notably, 92% of the dead children were born in Italy, but only 50% were followed-up since birth or within three months of age. Seventy three percent of children had started cART at age ≥6 months; 23% were treated for &lt;30 days before death. B and C clinical events progressively decreased ( P &lt; 0.0001). Opportunistic infections significantly decreased over time, but still were the most common events in all the periods (6.76/100 person-years in 2013–2018). In the last period, severe bacterial infections were the most common ones. Cancer rates were 0.07/100; 0.17/100; 0.07/100 person-years in the three periods, respectively. Conclusions: Progressive reductions both in mortality and in rates of class B and C clinical events and OIs have been observed during the cART era. However, deaths were still registered; more than half of dead children were enrolled after birth and had belatedly started cART." @default.
• W3185265447 created "2021-08-02" @default.
• W3185265447 creator A5002495981 @default.
• W3185265447 creator A5002590179 @default.
• W3185265447 creator A5002831988 @default.
• W3185265447 creator A5008622009 @default.
• W3185265447 creator A5009964366 @default.
• W3185265447 creator A5011090514 @default.
• W3185265447 creator A5014552570 @default.
• W3185265447 creator A5023419691 @default.
• W3185265447 creator A5024264050 @default.
• W3185265447 creator A5031724873 @default.
• W3185265447 creator A5033777139 @default.
• W3185265447 creator A5035205888 @default.
• W3185265447 creator A5035993792 @default.
• W3185265447 creator A5036224852 @default.
• W3185265447 creator A5037092719 @default.
• W3185265447 creator A5042594419 @default.
• W3185265447 creator A5044132959 @default.
• W3185265447 creator A5044230797 @default.
• W3185265447 creator A5046801644 @default.
• W3185265447 creator A5054549983 @default.
• W3185265447 creator A5056320600 @default.
• W3185265447 creator A5060526106 @default.
• W3185265447 creator A5068327775 @default.
• W3185265447 creator A5074034025 @default.
• W3185265447 creator A5074694529 @default.
• W3185265447 creator A5079172808 @default.
• W3185265447 creator A5082412933 @default.
• W3185265447 creator A5085325102 @default.
• W3185265447 creator A5086923044 @default.
• W3185265447 creator A5090613517 @default.
• W3185265447 date "2021-07-16" @default.
• W3185265447 modified "2023-10-14" @default.
• W3185265447 title "Real-World Analysis of Survival and Clinical Events in a Cohort of Italian Perinatally HIV-1 Infected Children From 2001 to 2018" @default.
• W3185265447 cites W1484620035 @default.
• W3185265447 cites W1529086182 @default.
• W3185265447 cites W1564364480 @default.
• W3185265447 cites W1971771720 @default.
• W3185265447 cites W1981937271 @default.
• W3185265447 cites W1985806982 @default.
• W3185265447 cites W1991443072 @default.
• W3185265447 cites W1991614900 @default.
• W3185265447 cites W1996083965 @default.
• W3185265447 cites W1997824449 @default.
• W3185265447 cites W2011026167 @default.
• W3185265447 cites W2013703920 @default.
• W3185265447 cites W2016333938 @default.
• W3185265447 cites W2040059881 @default.
• W3185265447 cites W2040656844 @default.
• W3185265447 cites W2060513447 @default.
• W3185265447 cites W2066885701 @default.
• W3185265447 cites W2068678898 @default.
• W3185265447 cites W2068703382 @default.
• W3185265447 cites W2072353432 @default.
• W3185265447 cites W2074512582 @default.
• W3185265447 cites W2079324608 @default.
• W3185265447 cites W2083148238 @default.
• W3185265447 cites W2096561020 @default.
• W3185265447 cites W2101208237 @default.
• W3185265447 cites W2116241967 @default.
• W3185265447 cites W2118749241 @default.
• W3185265447 cites W2122986037 @default.
• W3185265447 cites W2130508885 @default.
• W3185265447 cites W2132845988 @default.
• W3185265447 cites W2133262300 @default.
• W3185265447 cites W2143870105 @default.
• W3185265447 cites W2150751083 @default.
• W3185265447 cites W2152641956 @default.
• W3185265447 cites W2152722245 @default.
• W3185265447 cites W2154294731 @default.
• W3185265447 cites W2167647783 @default.
• W3185265447 cites W2188365714 @default.
• W3185265447 cites W2295774726 @default.
• W3185265447 cites W2304866602 @default.
• W3185265447 cites W2313180435 @default.
• W3185265447 cites W2319330000 @default.
• W3185265447 cites W2319635368 @default.
• W3185265447 cites W2610822349 @default.
• W3185265447 cites W2787586772 @default.
• W3185265447 cites W2795236974 @default.
• W3185265447 cites W2929110293 @default.
• W3185265447 cites W2960728409 @default.
• W3185265447 cites W2964520933 @default.
• W3185265447 cites W4230624578 @default.
• W3185265447 doi "https://doi.org/10.3389/fped.2021.665764" @default.
• W3185265447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8322739" @default.
• W3185265447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34336735" @default.
• W3185265447 hasPublicationYear "2021" @default.
• W3185265447 type Work @default.
• W3185265447 sameAs 3185265447 @default.
• W3185265447 citedByCount "6" @default.
• W3185265447 countsByYear W31852654472022 @default.
• W3185265447 countsByYear W31852654472023 @default.
• W3185265447 crossrefType "journal-article" @default.
• W3185265447 hasAuthorship W3185265447A5002495981 @default.
• W3185265447 hasAuthorship W3185265447A5002590179 @default.
• W3185265447 hasAuthorship W3185265447A5002831988 @default.
• W3185265447 hasAuthorship W3185265447A5008622009 @default.
• W3185265447 hasAuthorship W3185265447A5009964366 @default.

• next