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- W3185277097 endingPage "107490" @default.
- W3185277097 startingPage "107490" @default.
- W3185277097 abstract "Memories of emotionally arousing events tend to endure longer than other memories. This review compiles findings from several decades of research investigating the role of the amygdala in modulating memories of emotional experiences. Episodic memory is a kind of declarative memory that depends upon the hippocampus, and studies suggest that the basolateral complex of the amygdala (BLA) modulates episodic memory consolidation through interactions with the hippocampus. Although many studies in rodents and imaging studies in humans indicate that the amygdala modulates memory consolidation and plasticity processes in the hippocampus, the anatomical pathways through which the amygdala affects hippocampal regions that are important for episodic memories were unresolved until recent optogenetic advances made it possible to visualize and manipulate specific BLA efferent pathways during memory consolidation. Findings indicate that the BLA influences hippocampal-dependent memories, as well as synaptic plasticity, histone modifications, gene expression, and translation of synaptic plasticity associated proteins in the hippocampus. More recent findings from optogenetic studies suggest that the BLA modulates spatial memory via projections to the medial entorhinal cortex, and that the frequency of activity in this pathway is a critical element of this modulation." @default.
- W3185277097 created "2021-08-02" @default.
- W3185277097 creator A5027562840 @default.
- W3185277097 creator A5034971594 @default.
- W3185277097 creator A5036370920 @default.
- W3185277097 creator A5064149085 @default.
- W3185277097 date "2021-10-01" @default.
- W3185277097 modified "2023-10-13" @default.
- W3185277097 title "Amygdala-hippocampal interactions in synaptic plasticity and memory formation" @default.
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