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- W3185283049 abstract "For the response assessment after chemotherapy, the gold standard is always the histopathological response. However, the metabolic response can also guide further treatment. Herein, the aim of this study was to evaluate metabolic response assessment to neoadjuvant chemotherapy in SCC esophagus using PERSIST criteria with taking histopathological response by TRG as gold standard. This prospective study was conducted from April 2017 to Dec 2018 on SCC of esophagus patients. PET-CT was done before staring NACT and after getting 3 cycles for response assessment. Operable patients were taken up for surgery and final histopathological assessment was done by Mandard regression grading Metabolic response was assessed using SUVmax% change, tumor liver ratio (TLR) change and PERCIST. Total 57 patients were included in this study. All patients completed three cycles of NACT. 27 patients received cisplatin+5FU and 30 patients received paclitaxel +carboplatin. Total 38 patients underwent curative surgery. Based on PERCIST criteria 4 (7.01%) patients showed complete metabolic response. Simultaneously the metabolic response was also calculated by percentage change in TLR (Tumor liver ratio) and SUVmax. All three metabolic response tools were categorized and compared themselves. No statistically significant (p=0.34) difference was found for comparing the response by different methods but had weak agreement (k-0.28 with TLR, k-0.38 with SUVmax). On histopathology, 5 (13.1%) patients showed complete pathological response whereas grade III in 12 (31.6%) and grade IV response in 10 (26.3%) patients. No statistical difference was seen in the response assessed by PET scan and tumor regression grading (p=0.06) however showed moderate agreement (k-0.48). After NACT, PET/CT can help to assess the response and guide the treatment. These different metabolic tools can be used alone or in combination to assess the response." @default.
- W3185283049 created "2021-08-02" @default.
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- W3185283049 date "2021-07-01" @default.
- W3185283049 modified "2023-09-29" @default.
- W3185283049 title "MO20-6 A prospective study comparing metabolic tools on PET scan with Mandard grading following NACT in SCC of esophagus" @default.
- W3185283049 doi "https://doi.org/10.1016/j.annonc.2021.05.618" @default.
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