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- W3185307829 abstract "Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia. • The neuroendocrine response to hypoglycemia is severely impaired in Zucker rats. • Zucker rats exhibit a near absence of hypoglycemia-induced glucagon release. • Zucker rats exhibit an extremely truncated hypoglycemia-induced epinephrine release. • Hypoglycemia-induced corticosterone release was higher in Zucker rats relative to lean rats." @default.
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- W3185307829 date "2021-07-01" @default.
- W3185307829 modified "2023-10-17" @default.
- W3185307829 title "Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats" @default.
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- W3185307829 doi "https://doi.org/10.1016/j.jdiacomp.2021.107994" @default.
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