FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185435470> ?p ?o ?g. }

• W3185435470 endingPage "7947" @default.
• W3185435470 startingPage "7935" @default.
• W3185435470 abstract "Microvesicles (MV) contribute to cell-to-cell communication through their transported proteins and nucleic acids. MV, released into the extracellular space, exert paracrine regulation by modulating cellular responses after interaction with near and far target cells. MV are released at high concentrations by activated inflammatory cells. Different subtypes of human macrophages have been characterized based on surface epitopes being CD16+ macrophages associated with anti-inflammatory phenotypes. We have previously shown that low-density lipoprotein receptor-related protein 5 (LRP5), a member of the LDLR family that participates in lipid homeostasis, is expressed in macrophage CD16+ with repair and survival functions. The goal of our study was to characterize the cargo and tentative function of macrophage-derived MV, whether LRP5 is delivered into MV and whether these MV are able to induce inflammatory cell differentiation to a specific CD16- or CD16+ phenotype. We show, for the first time, that lipid-loaded macrophages release MV containing LRP5. LDL loading induces increased expression of macrophage pro-inflammatory markers and increased release of MV containing pro-inflammatory markers. Conditioning of fresh macrophages with MV released by Lrp5-silenced macrophages induced the transcription of inflammatory genes and reduced the transcription of anti-inflammatory genes. Thus, MV containing LRP5 induce anti-inflammatory phenotypes in macrophages." @default.
• W3185435470 created "2021-08-02" @default.
• W3185435470 creator A5072012691 @default.
• W3185435470 creator A5081257789 @default.
• W3185435470 creator A5089627250 @default.
• W3185435470 creator A5076411666 @default.
• W3185435470 date "2021-07-19" @default.
• W3185435470 modified "2023-10-14" @default.
• W3185435470 title "Microvesicles carrying LRP5 induce macrophage polarization to an anti‐inflammatory phenotype" @default.
• W3185435470 cites W1967367827 @default.
• W3185435470 cites W1970136916 @default.
• W3185435470 cites W1975066490 @default.
• W3185435470 cites W1977613047 @default.
• W3185435470 cites W1977692564 @default.
• W3185435470 cites W1985859986 @default.
• W3185435470 cites W1995622771 @default.
• W3185435470 cites W2006419043 @default.
• W3185435470 cites W2012166324 @default.
• W3185435470 cites W2019917125 @default.
• W3185435470 cites W2030135033 @default.
• W3185435470 cites W2031896007 @default.
• W3185435470 cites W2031930036 @default.
• W3185435470 cites W2043852077 @default.
• W3185435470 cites W2046758915 @default.
• W3185435470 cites W2047602000 @default.
• W3185435470 cites W2050643794 @default.
• W3185435470 cites W2054472394 @default.
• W3185435470 cites W2055313665 @default.
• W3185435470 cites W2071105928 @default.
• W3185435470 cites W2084687787 @default.
• W3185435470 cites W2086275775 @default.
• W3185435470 cites W2101460202 @default.
• W3185435470 cites W2107383916 @default.
• W3185435470 cites W2108541168 @default.
• W3185435470 cites W2111560326 @default.
• W3185435470 cites W2112187582 @default.
• W3185435470 cites W2115910133 @default.
• W3185435470 cites W2121121577 @default.
• W3185435470 cites W2127337667 @default.
• W3185435470 cites W2150761119 @default.
• W3185435470 cites W2193306095 @default.
• W3185435470 cites W2529210047 @default.
• W3185435470 cites W2586038252 @default.
• W3185435470 cites W2615463006 @default.
• W3185435470 cites W2620594759 @default.
• W3185435470 cites W2746521754 @default.
• W3185435470 cites W2903108867 @default.
• W3185435470 cites W2919278937 @default.
• W3185435470 cites W2951933160 @default.
• W3185435470 cites W2987547927 @default.
• W3185435470 cites W3009901926 @default.
• W3185435470 cites W3090714171 @default.
• W3185435470 cites W3185435470 @default.
• W3185435470 doi "https://doi.org/10.1111/jcmm.16723" @default.
• W3185435470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8358886" @default.
• W3185435470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34288375" @default.
• W3185435470 hasPublicationYear "2021" @default.
• W3185435470 type Work @default.
• W3185435470 sameAs 3185435470 @default.
• W3185435470 citedByCount "5" @default.
• W3185435470 countsByYear W31854354702021 @default.
• W3185435470 countsByYear W31854354702022 @default.
• W3185435470 countsByYear W31854354702023 @default.
• W3185435470 crossrefType "journal-article" @default.
• W3185435470 hasAuthorship W3185435470A5072012691 @default.
• W3185435470 hasAuthorship W3185435470A5076411666 @default.
• W3185435470 hasAuthorship W3185435470A5081257789 @default.
• W3185435470 hasAuthorship W3185435470A5089627250 @default.
• W3185435470 hasBestOaLocation W31854354701 @default.
• W3185435470 hasConcept C104317684 @default.
• W3185435470 hasConcept C114684123 @default.
• W3185435470 hasConcept C137620995 @default.
• W3185435470 hasConcept C145059251 @default.
• W3185435470 hasConcept C167672396 @default.
• W3185435470 hasConcept C182819311 @default.
• W3185435470 hasConcept C185592680 @default.
• W3185435470 hasConcept C202751555 @default.
• W3185435470 hasConcept C203014093 @default.
• W3185435470 hasConcept C20518536 @default.
• W3185435470 hasConcept C2776682551 @default.
• W3185435470 hasConcept C2776914184 @default.
• W3185435470 hasConcept C2779244956 @default.
• W3185435470 hasConcept C2781462264 @default.
• W3185435470 hasConcept C2909763251 @default.
• W3185435470 hasConcept C55493867 @default.
• W3185435470 hasConcept C62478195 @default.
• W3185435470 hasConcept C86803240 @default.
• W3185435470 hasConcept C8891405 @default.
• W3185435470 hasConcept C95444343 @default.
• W3185435470 hasConceptScore W3185435470C104317684 @default.
• W3185435470 hasConceptScore W3185435470C114684123 @default.
• W3185435470 hasConceptScore W3185435470C137620995 @default.
• W3185435470 hasConceptScore W3185435470C145059251 @default.
• W3185435470 hasConceptScore W3185435470C167672396 @default.
• W3185435470 hasConceptScore W3185435470C182819311 @default.
• W3185435470 hasConceptScore W3185435470C185592680 @default.
• W3185435470 hasConceptScore W3185435470C202751555 @default.
• W3185435470 hasConceptScore W3185435470C203014093 @default.

• next