Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185477291> ?p ?o ?g. }
- W3185477291 abstract "Hydrogels are key components in bioink formulations to ensure printability and stability in biofabrication. In this study, a well-known Diels-Alder two-step post-polymerization modification approach is introduced into thermogelling diblock copolymers, comprising poly(2-methyl-2-oxazoline) and thermoresponsive poly(2-n-propyl-2-oxazine). The diblock copolymers are partially hydrolyzed and subsequently modified by acid/amine coupling with furan and maleimide moieties. While the thermogelling and shear-thinning properties allow excellent printability, trigger-less cell-friendly Diels-Alder click-chemistry yields long-term shape-fidelity. The introduced platform enables easy incorporation of cell-binding moieties (RGD-peptide) for cellular interaction. The hydrogel is functionalized with RGD-peptides using thiol-maleimide chemistry and cell proliferation as well as morphology of fibroblasts seeded on top of the hydrogels confirm the cell adhesion facilitated by the peptides. Finally, bioink formulations are tested for biocompatibility by incorporating fibroblasts homogenously inside the polymer solution pre-printing. After the printing and crosslinking process good cytocompatibility is confirmed. The established bioink system combines a two-step approach by physical precursor gelation followed by an additional chemical stabilization, offering a broad versatility for further biomechanical adaptation or bioresponsive peptide modification." @default.
- W3185477291 created "2021-08-02" @default.
- W3185477291 creator A5000977163 @default.
- W3185477291 creator A5006657051 @default.
- W3185477291 creator A5006839660 @default.
- W3185477291 creator A5010196373 @default.
- W3185477291 creator A5021321425 @default.
- W3185477291 creator A5025070309 @default.
- W3185477291 creator A5027517227 @default.
- W3185477291 creator A5056461337 @default.
- W3185477291 creator A5059851683 @default.
- W3185477291 creator A5069394712 @default.
- W3185477291 creator A5079075921 @default.
- W3185477291 creator A5082426256 @default.
- W3185477291 date "2021-07-22" @default.
- W3185477291 modified "2023-10-13" @default.
- W3185477291 title "From Thermogelling Hydrogels toward Functional Bioinks: Controlled Modification and Cytocompatible Crosslinking" @default.
- W3185477291 cites W1544137929 @default.
- W3185477291 cites W1712514116 @default.
- W3185477291 cites W1989110038 @default.
- W3185477291 cites W1994070029 @default.
- W3185477291 cites W2001952247 @default.
- W3185477291 cites W2003194781 @default.
- W3185477291 cites W2008632097 @default.
- W3185477291 cites W2016445978 @default.
- W3185477291 cites W2035745353 @default.
- W3185477291 cites W2059686778 @default.
- W3185477291 cites W2061471850 @default.
- W3185477291 cites W2061761744 @default.
- W3185477291 cites W2062495055 @default.
- W3185477291 cites W2086608111 @default.
- W3185477291 cites W2134715422 @default.
- W3185477291 cites W2188096331 @default.
- W3185477291 cites W2226257595 @default.
- W3185477291 cites W2360872800 @default.
- W3185477291 cites W2404768192 @default.
- W3185477291 cites W2491221858 @default.
- W3185477291 cites W2518749493 @default.
- W3185477291 cites W2520718776 @default.
- W3185477291 cites W2531421987 @default.
- W3185477291 cites W2712701535 @default.
- W3185477291 cites W2743143384 @default.
- W3185477291 cites W2765341240 @default.
- W3185477291 cites W2765595220 @default.
- W3185477291 cites W2767585628 @default.
- W3185477291 cites W2787931177 @default.
- W3185477291 cites W2793763826 @default.
- W3185477291 cites W2795957570 @default.
- W3185477291 cites W2807377921 @default.
- W3185477291 cites W2808914432 @default.
- W3185477291 cites W2890471755 @default.
- W3185477291 cites W2896014030 @default.
- W3185477291 cites W2898695058 @default.
- W3185477291 cites W2900058404 @default.
- W3185477291 cites W2955382973 @default.
- W3185477291 cites W2965395580 @default.
- W3185477291 cites W2966241426 @default.
- W3185477291 cites W2979512365 @default.
- W3185477291 cites W2981996270 @default.
- W3185477291 cites W2984615507 @default.
- W3185477291 cites W2984616607 @default.
- W3185477291 cites W2986518463 @default.
- W3185477291 cites W2993112887 @default.
- W3185477291 cites W3007138159 @default.
- W3185477291 cites W3010524097 @default.
- W3185477291 cites W3016832090 @default.
- W3185477291 cites W3018306979 @default.
- W3185477291 cites W3032657203 @default.
- W3185477291 cites W3043626412 @default.
- W3185477291 cites W3046733325 @default.
- W3185477291 cites W3047176319 @default.
- W3185477291 cites W3088653478 @default.
- W3185477291 cites W3120778575 @default.
- W3185477291 doi "https://doi.org/10.1002/mabi.202100122" @default.
- W3185477291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34292657" @default.
- W3185477291 hasPublicationYear "2021" @default.
- W3185477291 type Work @default.
- W3185477291 sameAs 3185477291 @default.
- W3185477291 citedByCount "11" @default.
- W3185477291 countsByYear W31854772912022 @default.
- W3185477291 countsByYear W31854772912023 @default.
- W3185477291 crossrefType "journal-article" @default.
- W3185477291 hasAuthorship W3185477291A5000977163 @default.
- W3185477291 hasAuthorship W3185477291A5006657051 @default.
- W3185477291 hasAuthorship W3185477291A5006839660 @default.
- W3185477291 hasAuthorship W3185477291A5010196373 @default.
- W3185477291 hasAuthorship W3185477291A5021321425 @default.
- W3185477291 hasAuthorship W3185477291A5025070309 @default.
- W3185477291 hasAuthorship W3185477291A5027517227 @default.
- W3185477291 hasAuthorship W3185477291A5056461337 @default.
- W3185477291 hasAuthorship W3185477291A5059851683 @default.
- W3185477291 hasAuthorship W3185477291A5069394712 @default.
- W3185477291 hasAuthorship W3185477291A5079075921 @default.
- W3185477291 hasAuthorship W3185477291A5082426256 @default.
- W3185477291 hasBestOaLocation W31854772912 @default.
- W3185477291 hasConcept C108586683 @default.
- W3185477291 hasConcept C15920480 @default.
- W3185477291 hasConcept C171250308 @default.
- W3185477291 hasConcept C178790620 @default.
- W3185477291 hasConcept C185592680 @default.