FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185492042> ?p ?o ?g. }

• W3185492042 endingPage "1175" @default.
• W3185492042 startingPage "1175" @default.
• W3185492042 abstract "Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotoxemia by inhibition of GLP-1 degradation. Here we investigate the effects of Lira in the polymicrobial sepsis model of cecal ligation and puncture (CLP). C57BL/6J mice were intraperitoneally injected with Lira (200 µg/kg/d; 3 days) and sepsis induced by CLP after one day of GLP-1 analog treatment. Survival and body temperature were monitored. Aortic vascular function (isometric tension recording), protein expression (immunohistochemistry and dot blot) and gene expression (qRT-PCR) were determined. Endothelium-dependent relaxation in the aorta was impaired by CLP and correlated with markers of inflammation (e.g., interleukin 6 and inducible nitric oxide synthase) and oxidative stress (e.g., 3-nitrotyrosine) was higher in septic mice, all of which was almost completely normalized by Lira therapy. We demonstrate that the GLP-1 analog Lira ameliorates sepsis-induced endothelial dysfunction by the reduction of vascular inflammation and oxidative stress. Accordingly, the findings suggest that the antioxidant and anti-inflammatory effects of GLP-1 analogs may be a valuable tool to protect the cardiovascular system from dysbalanced inflammation in polymicrobial sepsis." @default.
• W3185492042 created "2021-08-02" @default.
• W3185492042 creator A5015861190 @default.
• W3185492042 creator A5034038591 @default.
• W3185492042 creator A5035254382 @default.
• W3185492042 creator A5035283624 @default.
• W3185492042 creator A5039361810 @default.
• W3185492042 creator A5039932947 @default.
• W3185492042 creator A5055650937 @default.
• W3185492042 creator A5064993444 @default.
• W3185492042 creator A5066963864 @default.
• W3185492042 creator A5068831026 @default.
• W3185492042 creator A5072269331 @default.
• W3185492042 creator A5075095307 @default.
• W3185492042 creator A5079626576 @default.
• W3185492042 creator A5083135078 @default.
• W3185492042 creator A5090175367 @default.
• W3185492042 date "2021-07-23" @default.
• W3185492042 modified "2023-10-17" @default.
• W3185492042 title "GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation" @default.
• W3185492042 cites W1725300350 @default.
• W3185492042 cites W1963975982 @default.
• W3185492042 cites W1968678717 @default.
• W3185492042 cites W1972876739 @default.
• W3185492042 cites W1989224728 @default.
• W3185492042 cites W1999120747 @default.
• W3185492042 cites W1999880393 @default.
• W3185492042 cites W2011963516 @default.
• W3185492042 cites W2023376910 @default.
• W3185492042 cites W2023945291 @default.
• W3185492042 cites W2029463317 @default.
• W3185492042 cites W2035433014 @default.
• W3185492042 cites W2051705991 @default.
• W3185492042 cites W2055247780 @default.
• W3185492042 cites W2055611619 @default.
• W3185492042 cites W2055678371 @default.
• W3185492042 cites W2059407166 @default.
• W3185492042 cites W2064909979 @default.
• W3185492042 cites W2065623326 @default.
• W3185492042 cites W2075567076 @default.
• W3185492042 cites W2084948079 @default.
• W3185492042 cites W2114531479 @default.
• W3185492042 cites W2116835524 @default.
• W3185492042 cites W2134812217 @default.
• W3185492042 cites W2142097676 @default.
• W3185492042 cites W2166383881 @default.
• W3185492042 cites W2166817188 @default.
• W3185492042 cites W2306319461 @default.
• W3185492042 cites W2308305952 @default.
• W3185492042 cites W2319791229 @default.
• W3185492042 cites W2425644022 @default.
• W3185492042 cites W2475233216 @default.
• W3185492042 cites W2516298414 @default.
• W3185492042 cites W2589326907 @default.
• W3185492042 cites W2602843154 @default.
• W3185492042 cites W2620241325 @default.
• W3185492042 cites W2746874591 @default.
• W3185492042 cites W2766755483 @default.
• W3185492042 cites W2795481136 @default.
• W3185492042 cites W2807873759 @default.
• W3185492042 cites W2891799542 @default.
• W3185492042 cites W2951345394 @default.
• W3185492042 cites W2980320630 @default.
• W3185492042 cites W2980881483 @default.
• W3185492042 cites W2990541661 @default.
• W3185492042 cites W2997321171 @default.
• W3185492042 cites W3011570802 @default.
• W3185492042 cites W3106686829 @default.
• W3185492042 cites W3138099017 @default.
• W3185492042 cites W4235902209 @default.
• W3185492042 cites W4294216491 @default.
• W3185492042 doi "https://doi.org/10.3390/antiox10081175" @default.
• W3185492042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8388926" @default.
• W3185492042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34439423" @default.
• W3185492042 hasPublicationYear "2021" @default.
• W3185492042 type Work @default.
• W3185492042 sameAs 3185492042 @default.
• W3185492042 citedByCount "15" @default.
• W3185492042 countsByYear W31854920422021 @default.
• W3185492042 countsByYear W31854920422022 @default.
• W3185492042 countsByYear W31854920422023 @default.
• W3185492042 crossrefType "journal-article" @default.
• W3185492042 hasAuthorship W3185492042A5015861190 @default.
• W3185492042 hasAuthorship W3185492042A5034038591 @default.
• W3185492042 hasAuthorship W3185492042A5035254382 @default.
• W3185492042 hasAuthorship W3185492042A5035283624 @default.
• W3185492042 hasAuthorship W3185492042A5039361810 @default.
• W3185492042 hasAuthorship W3185492042A5039932947 @default.
• W3185492042 hasAuthorship W3185492042A5055650937 @default.
• W3185492042 hasAuthorship W3185492042A5064993444 @default.
• W3185492042 hasAuthorship W3185492042A5066963864 @default.
• W3185492042 hasAuthorship W3185492042A5068831026 @default.
• W3185492042 hasAuthorship W3185492042A5072269331 @default.
• W3185492042 hasAuthorship W3185492042A5075095307 @default.
• W3185492042 hasAuthorship W3185492042A5079626576 @default.
• W3185492042 hasAuthorship W3185492042A5083135078 @default.
• W3185492042 hasAuthorship W3185492042A5090175367 @default.
• W3185492042 hasBestOaLocation W31854920421 @default.

• next