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- W3185577434 abstract "Extensive research over the past half a century indicates that reactive oxygen species (ROS) play an important role in cancer. ROS are small molecules from the partial reduction of molecular oxygen during oxygen consumption and cellular metabolism. Increased ROS levels have been observed in various cancers. The abnormal concentration of ROS can activate signaling pathways about cancer cell survival, tumor progression, drug resistance, and driven DNA damage and genetic instability [1]. Precisely regulated antioxidant defense system in cancer cells can detoxify elevated ROS levels while maintaining pro-tumorigenic signaling and resistance to apoptosis. However, if the balance of redox status was disturbed, ROS may exert a cytotoxic effect which induces malignant cell death. It has been explored to selectively kill cancer cells without damage normal cells by manipulating ROS levels and antioxidant systems [2]. ROS-generating and elimination agents have been applied and found effective in many cases. Arsenic trioxide can impair the respiratory chain and increase superoxide production while doxorubicin can induce ROS production by intracellular chelation of iron and trigger a Fenton-type reaction leading to the generation of the highly reactive hydroxyl radical. Depletion of the GSH pool, which is the major ROS-scavenging system in cells, can increase oxidative stress and cell death. To maximize the therapeutic effect, a combination of arsenic trioxide and ascorbic acid-mediated GSH depletion has been exploited and showed clinically effective in the treatment of myeloma. Thus the quantitative determination of ROS in cells is in great demand in clinical cancer treatment and basic research. The non-enzymatic electrochemical sensor is excellent stable, reproducible, and cost-effective with no need to immobilize enzymes on the electrode surface [4]. To increase the activity and selectivity, Au-based nanoparticles are of particular interest for their great conductivity and superior electrochemical properties. By introducing the MWCNTs as supporting material due to their excellent electrical conductivity and large surface area, the electrocatalytic activity can be further improved." @default.
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- W3185577434 date "2021-05-30" @default.
- W3185577434 modified "2023-10-16" @default.
- W3185577434 title "Cell-Based Electrochemical Biosensor for Evaluating the Oxidant Stress Levels Induced By Specific Anti-Cancer Drugs" @default.
- W3185577434 doi "https://doi.org/10.1149/ma2021-01551378mtgabs" @default.
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