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- W3185611478 endingPage "7881" @default.
- W3185611478 startingPage "7881" @default.
- W3185611478 abstract "Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has been recognized as a key mediator of DN. However, anti-TGF-β treatment for DN remains controversial due to the diverse role of TGF-β1 in DN. Thus, understanding the regulatory role and mechanisms of TGF-β in the pathogenesis of DN is the initial step towards the development of anti-TGF-β treatment for DN. In this review, we first discuss the diverse roles and signaling mechanisms of TGF-β in DN by focusing on the latent versus active TGF-β1, the TGF-β receptors, and the downstream individual Smad signaling molecules including Smad2, Smad3, Smad4, and Smad7. Then, we dissect the regulatory mechanisms of TGF-β/Smad signaling in the development of DN by emphasizing Smad-dependent non-coding RNAs including microRNAs and long-non-coding RNAs. Finally, the potential therapeutic strategies for DN by targeting TGF-β signaling with various therapeutic approaches are discussed." @default.
- W3185611478 created "2021-08-02" @default.
- W3185611478 creator A5012278873 @default.
- W3185611478 creator A5031048617 @default.
- W3185611478 creator A5043652524 @default.
- W3185611478 creator A5061472855 @default.
- W3185611478 date "2021-07-23" @default.
- W3185611478 modified "2023-10-16" @default.
- W3185611478 title "TGF-Beta as a Master Regulator of Diabetic Nephropathy" @default.
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