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• W3185683873 endingPage "1870" @default.
• W3185683873 startingPage "1870" @default.
• W3185683873 abstract "Rhabdomyosarcoma (RMS), is the most frequent soft tissue tumor in children that originates from disturbances in differentiation process. Mechanisms leading to the development of RMS are still poorly understood. Therefore, by analysis of two RMS RH30 cell line subclones, one subclone PAX7 negative, while the second one PAX7 positive, and comparison with other RMS cell lines we aimed at identifying new mechanisms crucial for RMS progression. RH30 subclones were characterized by the same STR profile, but different morphology, rate of proliferation, migration activity and chemotactic abilities in vitro, as well as differences in tumor morphology and growth in vivo. Our analysis indicated a different level of expression of adhesion molecules (e.g., from VLA and ICAM families), myogenic microRNAs, such as miR-206 and transcription factors, such as MYOD, MYOG, SIX1, and ID. Silencing of PAX7 transcription factor with siRNA confirmed the crucial role of PAX7 transcription factor in proliferation, differentiation and migration of RMS cells. To conclude, our results suggest that tumor cell lines with the same STR profile can produce subclones that differ in many features and indicate crucial roles of PAX7 and ID proteins in the development of RMS." @default.
• W3185683873 created "2021-08-02" @default.
• W3185683873 creator A5004478837 @default.
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• W3185683873 creator A5062048908 @default.
• W3185683873 creator A5064183255 @default.
• W3185683873 creator A5072112702 @default.
• W3185683873 date "2021-07-23" @default.
• W3185683873 modified "2023-10-17" @default.
• W3185683873 title "Progression and Differentiation of Alveolar Rhabdomyosarcoma Is Regulated by PAX7 Transcription Factor—Significance of Tumor Subclones" @default.
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• W3185683873 doi "https://doi.org/10.3390/cells10081870" @default.
• W3185683873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8391953" @default.
• W3185683873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34440639" @default.
• W3185683873 hasPublicationYear "2021" @default.
• W3185683873 type Work @default.

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