Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185723016> ?p ?o ?g. }
- W3185723016 endingPage "1233" @default.
- W3185723016 startingPage "1226" @default.
- W3185723016 abstract "Hyperthyroidism influences the development of cardiac hypertrophy. Transient receptor potential canonical channels (TRPCs) and endoplasmic reticulum (ER) stress are regarded as critical pathways in cardiac hypertrophy. Hence, we aimed to identify the TRPCs associated with ER stress in hyperthyroidism-induced cardiac hypertrophy. Twenty adult Wistar albino male rats were used in the study. The control group was fed with standard food and tap water. The group with hyperthyroidism was also fed with standard rat food, along with tap water that contained 12 mg/L of thyroxine (T4) for 4 weeks. At the end of the fourth week, the serum-free triiodothyronine (T3), T4, and thyroid-stimulating hormone (TSH) levels of the groups were measured. The left ventricle of each rat was used for histochemistry, immunohistochemistry, Western blot, total antioxidant capacity (TAC), and total oxidant status (TOS) analysis. As per our results, activating transcription factor 6 (ATF-6), inositol-requiring kinase 1 (IRE-1), and TRPC1, which play a significant role in cardiac hypertrophy caused by hyperthyroidism, showed increased activation. Moreover, TOS and serum-free T3 levels increased, while TAC and TSH levels decreased. With the help of the literature review in our study, we could, for the first time, indicate that the increased activation of ATF-6, IRE-1, and TRPC1-induced deterioration of the Ca2+ ion balance leads to hypertrophy in hyperthyroidism due to heart failure." @default.
- W3185723016 created "2021-08-02" @default.
- W3185723016 creator A5022648232 @default.
- W3185723016 creator A5044385576 @default.
- W3185723016 creator A5056916259 @default.
- W3185723016 creator A5059114639 @default.
- W3185723016 creator A5088176226 @default.
- W3185723016 creator A5089129259 @default.
- W3185723016 creator A5091495979 @default.
- W3185723016 date "2021-11-01" @default.
- W3185723016 modified "2023-09-26" @default.
- W3185723016 title "Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels" @default.
- W3185723016 cites W133016843 @default.
- W3185723016 cites W1516382070 @default.
- W3185723016 cites W1546139069 @default.
- W3185723016 cites W1976161806 @default.
- W3185723016 cites W1981261137 @default.
- W3185723016 cites W1991131183 @default.
- W3185723016 cites W1993536160 @default.
- W3185723016 cites W1997785662 @default.
- W3185723016 cites W2000277025 @default.
- W3185723016 cites W2012945122 @default.
- W3185723016 cites W2016294684 @default.
- W3185723016 cites W2035744905 @default.
- W3185723016 cites W2038109543 @default.
- W3185723016 cites W2052817643 @default.
- W3185723016 cites W2052985285 @default.
- W3185723016 cites W2060594376 @default.
- W3185723016 cites W2073996953 @default.
- W3185723016 cites W2089198803 @default.
- W3185723016 cites W2101166125 @default.
- W3185723016 cites W2102038264 @default.
- W3185723016 cites W2102277479 @default.
- W3185723016 cites W2128479397 @default.
- W3185723016 cites W2129439677 @default.
- W3185723016 cites W2140035123 @default.
- W3185723016 cites W2292468503 @default.
- W3185723016 cites W2294419491 @default.
- W3185723016 cites W2334499091 @default.
- W3185723016 cites W2560230402 @default.
- W3185723016 cites W2616892172 @default.
- W3185723016 cites W2736146023 @default.
- W3185723016 cites W2895157998 @default.
- W3185723016 cites W2899091393 @default.
- W3185723016 cites W2922295430 @default.
- W3185723016 cites W2939517625 @default.
- W3185723016 cites W981924069 @default.
- W3185723016 cites W2108546210 @default.
- W3185723016 doi "https://doi.org/10.1139/cjpp-2021-0260" @default.
- W3185723016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34283935" @default.
- W3185723016 hasPublicationYear "2021" @default.
- W3185723016 type Work @default.
- W3185723016 sameAs 3185723016 @default.
- W3185723016 citedByCount "6" @default.
- W3185723016 countsByYear W31857230162022 @default.
- W3185723016 countsByYear W31857230162023 @default.
- W3185723016 crossrefType "journal-article" @default.
- W3185723016 hasAuthorship W3185723016A5022648232 @default.
- W3185723016 hasAuthorship W3185723016A5044385576 @default.
- W3185723016 hasAuthorship W3185723016A5056916259 @default.
- W3185723016 hasAuthorship W3185723016A5059114639 @default.
- W3185723016 hasAuthorship W3185723016A5088176226 @default.
- W3185723016 hasAuthorship W3185723016A5089129259 @default.
- W3185723016 hasAuthorship W3185723016A5091495979 @default.
- W3185723016 hasBestOaLocation W31857230162 @default.
- W3185723016 hasConcept C104317684 @default.
- W3185723016 hasConcept C126322002 @default.
- W3185723016 hasConcept C134018914 @default.
- W3185723016 hasConcept C155164980 @default.
- W3185723016 hasConcept C167007842 @default.
- W3185723016 hasConcept C167414201 @default.
- W3185723016 hasConcept C170493617 @default.
- W3185723016 hasConcept C185592680 @default.
- W3185723016 hasConcept C2776002628 @default.
- W3185723016 hasConcept C2776415932 @default.
- W3185723016 hasConcept C2778198053 @default.
- W3185723016 hasConcept C2778288131 @default.
- W3185723016 hasConcept C2778921608 @default.
- W3185723016 hasConcept C55493867 @default.
- W3185723016 hasConcept C71315377 @default.
- W3185723016 hasConcept C71924100 @default.
- W3185723016 hasConcept C84393581 @default.
- W3185723016 hasConceptScore W3185723016C104317684 @default.
- W3185723016 hasConceptScore W3185723016C126322002 @default.
- W3185723016 hasConceptScore W3185723016C134018914 @default.
- W3185723016 hasConceptScore W3185723016C155164980 @default.
- W3185723016 hasConceptScore W3185723016C167007842 @default.
- W3185723016 hasConceptScore W3185723016C167414201 @default.
- W3185723016 hasConceptScore W3185723016C170493617 @default.
- W3185723016 hasConceptScore W3185723016C185592680 @default.
- W3185723016 hasConceptScore W3185723016C2776002628 @default.
- W3185723016 hasConceptScore W3185723016C2776415932 @default.
- W3185723016 hasConceptScore W3185723016C2778198053 @default.
- W3185723016 hasConceptScore W3185723016C2778288131 @default.
- W3185723016 hasConceptScore W3185723016C2778921608 @default.
- W3185723016 hasConceptScore W3185723016C55493867 @default.
- W3185723016 hasConceptScore W3185723016C71315377 @default.
- W3185723016 hasConceptScore W3185723016C71924100 @default.