Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185746590> ?p ?o ?g. }
- W3185746590 endingPage "18" @default.
- W3185746590 startingPage "4" @default.
- W3185746590 abstract "Metabolite lactic acid has always been regarded as a metabolic by-product rather than a bioactive molecule. Recently, this view has changed since it was discovered that lactic acid can be used as a signal molecule and has novel signal transduction functions both intracellular and extracellular, which can regulate key functions in the immune system. In recent years, more and more evidence has shown that lactic acid is closely related to the metabolism and polarization of macrophages. During inflammation, lactic acid is a regulator of macrophage metabolism, and it can prevent excessive inflammatory responses; In malignant tumors, lactic acid produced by tumor tissues promotes the polarization of tumor-associated macrophages, which in turn promotes tumor progression. In this review, we examined the relationship between lactic acid and macrophage metabolism. We further discussed how lactic acid plays a role in maintaining the homeostasis of macrophages, as well as the biology of macrophage polarization and the M1/M2 imbalance in human diseases. Potential methods to target lactic acid in the treatment of inflammation and cancer will also be discussed so as to provide new strategies for the treatment of diseases." @default.
- W3185746590 created "2021-08-02" @default.
- W3185746590 creator A5001838489 @default.
- W3185746590 creator A5004802355 @default.
- W3185746590 creator A5006633118 @default.
- W3185746590 creator A5041789177 @default.
- W3185746590 creator A5047708304 @default.
- W3185746590 creator A5052531064 @default.
- W3185746590 creator A5056183335 @default.
- W3185746590 creator A5068348950 @default.
- W3185746590 creator A5090456613 @default.
- W3185746590 date "2021-07-25" @default.
- W3185746590 modified "2023-10-02" @default.
- W3185746590 title "Lactic acid in macrophage polarization: The significant role in inflammation and cancer" @default.
- W3185746590 cites W1011212340 @default.
- W3185746590 cites W1486200716 @default.
- W3185746590 cites W1519056349 @default.
- W3185746590 cites W1544249031 @default.
- W3185746590 cites W1571252195 @default.
- W3185746590 cites W1916893403 @default.
- W3185746590 cites W1971620413 @default.
- W3185746590 cites W1975182142 @default.
- W3185746590 cites W1976619935 @default.
- W3185746590 cites W1989156064 @default.
- W3185746590 cites W2002351312 @default.
- W3185746590 cites W2005539293 @default.
- W3185746590 cites W2006540005 @default.
- W3185746590 cites W2016662511 @default.
- W3185746590 cites W2020369202 @default.
- W3185746590 cites W2022720370 @default.
- W3185746590 cites W2034400622 @default.
- W3185746590 cites W2035566116 @default.
- W3185746590 cites W2042207589 @default.
- W3185746590 cites W2058429236 @default.
- W3185746590 cites W2061462107 @default.
- W3185746590 cites W2063632665 @default.
- W3185746590 cites W2064081167 @default.
- W3185746590 cites W2067031028 @default.
- W3185746590 cites W2074095995 @default.
- W3185746590 cites W2086554547 @default.
- W3185746590 cites W2096008021 @default.
- W3185746590 cites W2106102605 @default.
- W3185746590 cites W2135141709 @default.
- W3185746590 cites W2136428555 @default.
- W3185746590 cites W2144002025 @default.
- W3185746590 cites W2147665517 @default.
- W3185746590 cites W2164178708 @default.
- W3185746590 cites W2202641067 @default.
- W3185746590 cites W2204185518 @default.
- W3185746590 cites W2213144761 @default.
- W3185746590 cites W2234115940 @default.
- W3185746590 cites W2283191725 @default.
- W3185746590 cites W2286673285 @default.
- W3185746590 cites W2333427125 @default.
- W3185746590 cites W2436504951 @default.
- W3185746590 cites W2496428480 @default.
- W3185746590 cites W2519733268 @default.
- W3185746590 cites W2535357498 @default.
- W3185746590 cites W2549406935 @default.
- W3185746590 cites W2559001989 @default.
- W3185746590 cites W2560915235 @default.
- W3185746590 cites W2565303118 @default.
- W3185746590 cites W2567661897 @default.
- W3185746590 cites W2585139079 @default.
- W3185746590 cites W2587833196 @default.
- W3185746590 cites W2604465118 @default.
- W3185746590 cites W2612351849 @default.
- W3185746590 cites W2624639454 @default.
- W3185746590 cites W2625416742 @default.
- W3185746590 cites W2729449808 @default.
- W3185746590 cites W2741667950 @default.
- W3185746590 cites W2746891430 @default.
- W3185746590 cites W2749736089 @default.
- W3185746590 cites W2762717139 @default.
- W3185746590 cites W2765733637 @default.
- W3185746590 cites W2767568355 @default.
- W3185746590 cites W2777598902 @default.
- W3185746590 cites W2780932821 @default.
- W3185746590 cites W2782685575 @default.
- W3185746590 cites W2789730644 @default.
- W3185746590 cites W2790658373 @default.
- W3185746590 cites W2791416031 @default.
- W3185746590 cites W2792935190 @default.
- W3185746590 cites W2795178600 @default.
- W3185746590 cites W2795504602 @default.
- W3185746590 cites W2796142839 @default.
- W3185746590 cites W2803151969 @default.
- W3185746590 cites W2806355319 @default.
- W3185746590 cites W2811379320 @default.
- W3185746590 cites W2885765614 @default.
- W3185746590 cites W2885985894 @default.
- W3185746590 cites W2892171609 @default.
- W3185746590 cites W2897752129 @default.
- W3185746590 cites W2900607960 @default.
- W3185746590 cites W2901886557 @default.
- W3185746590 cites W2901939398 @default.
- W3185746590 cites W2901951820 @default.
- W3185746590 cites W2903916121 @default.