FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185769050> ?p ?o ?g. }

• W3185769050 abstract "Microglia are highly dynamic cells crucial for developing and maintaining lifelong brain function and health through their many interactions with essentially all cellular components of the central nervous system. The frequent connection of microglia to leukodystrophies, genetic disorders of the white matter, has highlighted their involvement in the maintenance of white matter integrity. However, the mechanisms that underlie their putative roles in these processes remain largely uncharacterized. Microglia have also been gaining attention as possible therapeutic targets for many neurological conditions, increasing the demand to understand their broad spectrum of functions and the impact of their dysregulation. In this Review, we compare the pathological features of two groups of genetic leukodystrophies: those in which microglial dysfunction holds a central role, termed 'microgliopathies', and those in which lysosomal or peroxisomal defects are considered to be the primary driver. The latter are suspected to have notable microglia involvement, as some affected individuals benefit from microglia-replenishing therapy. Based on overlapping pathology, we discuss multiple ways through which aberrant microglia could lead to white matter defects and brain dysfunction. We propose that the study of leukodystrophies, and their extensively multicellular pathology, will benefit from complementing analyses of human patient material with the examination of cellular dynamics in vivo using animal models, such as zebrafish. Together, this will yield important insight into the cell biological mechanisms of microglial impact in the central nervous system, particularly in the development and maintenance of myelin, that will facilitate the development of new, and refinement of existing, therapeutic options for a range of brain diseases." @default.
• W3185769050 created "2021-08-02" @default.
• W3185769050 creator A5017407479 @default.
• W3185769050 creator A5061851798 @default.
• W3185769050 creator A5068007651 @default.
• W3185769050 date "2021-07-20" @default.
• W3185769050 modified "2023-09-27" @default.
• W3185769050 title "The multicellular interplay of microglia in health and disease: lessons from leukodystrophy" @default.
• W3185769050 cites W120621740 @default.
• W3185769050 cites W1526562091 @default.
• W3185769050 cites W1528278198 @default.
• W3185769050 cites W1542339011 @default.
• W3185769050 cites W1595413626 @default.
• W3185769050 cites W1606673973 @default.
• W3185769050 cites W1615535881 @default.
• W3185769050 cites W1758833828 @default.
• W3185769050 cites W1765894768 @default.
• W3185769050 cites W1893315106 @default.
• W3185769050 cites W1948478725 @default.
• W3185769050 cites W1964041350 @default.
• W3185769050 cites W1977213877 @default.
• W3185769050 cites W1980789245 @default.
• W3185769050 cites W1981239255 @default.
• W3185769050 cites W1984269879 @default.
• W3185769050 cites W1984701456 @default.
• W3185769050 cites W1985845421 @default.
• W3185769050 cites W1988605914 @default.
• W3185769050 cites W1991732233 @default.
• W3185769050 cites W1992509114 @default.
• W3185769050 cites W1994682897 @default.
• W3185769050 cites W1996024251 @default.
• W3185769050 cites W1996596731 @default.
• W3185769050 cites W1997816650 @default.
• W3185769050 cites W2001188679 @default.
• W3185769050 cites W2001612492 @default.
• W3185769050 cites W2005267396 @default.
• W3185769050 cites W2005303635 @default.
• W3185769050 cites W2007952700 @default.
• W3185769050 cites W2008423294 @default.
• W3185769050 cites W2008921519 @default.
• W3185769050 cites W2013371492 @default.
• W3185769050 cites W2014200126 @default.
• W3185769050 cites W2016920358 @default.
• W3185769050 cites W2017867302 @default.
• W3185769050 cites W2018338123 @default.
• W3185769050 cites W2022794439 @default.
• W3185769050 cites W2026279003 @default.
• W3185769050 cites W2028617079 @default.
• W3185769050 cites W2029906813 @default.
• W3185769050 cites W2031603575 @default.
• W3185769050 cites W2033617297 @default.
• W3185769050 cites W2040018188 @default.
• W3185769050 cites W2042698977 @default.
• W3185769050 cites W2044218446 @default.
• W3185769050 cites W2045262404 @default.
• W3185769050 cites W2046997550 @default.
• W3185769050 cites W2047899819 @default.
• W3185769050 cites W2052721785 @default.
• W3185769050 cites W2055348159 @default.
• W3185769050 cites W2057179364 @default.
• W3185769050 cites W2058669152 @default.
• W3185769050 cites W2060915232 @default.
• W3185769050 cites W2062916819 @default.
• W3185769050 cites W2065695164 @default.
• W3185769050 cites W2066943555 @default.
• W3185769050 cites W2068475929 @default.
• W3185769050 cites W2069264323 @default.
• W3185769050 cites W2070006166 @default.
• W3185769050 cites W2071336988 @default.
• W3185769050 cites W2073632222 @default.
• W3185769050 cites W2078581257 @default.
• W3185769050 cites W2080092859 @default.
• W3185769050 cites W2085663788 @default.
• W3185769050 cites W2085675651 @default.
• W3185769050 cites W2090106964 @default.
• W3185769050 cites W2091175651 @default.
• W3185769050 cites W2091497743 @default.
• W3185769050 cites W2091719983 @default.
• W3185769050 cites W2092440284 @default.
• W3185769050 cites W2093857516 @default.
• W3185769050 cites W2094373497 @default.
• W3185769050 cites W2094660330 @default.
• W3185769050 cites W2094831055 @default.
• W3185769050 cites W2095931805 @default.
• W3185769050 cites W2096327192 @default.
• W3185769050 cites W2096423240 @default.
• W3185769050 cites W2097365950 @default.
• W3185769050 cites W2103037576 @default.
• W3185769050 cites W2103551931 @default.
• W3185769050 cites W2105156168 @default.
• W3185769050 cites W2107696332 @default.
• W3185769050 cites W2108233057 @default.
• W3185769050 cites W2114354962 @default.
• W3185769050 cites W2115736737 @default.
• W3185769050 cites W2116543707 @default.
• W3185769050 cites W2122828560 @default.
• W3185769050 cites W2130917382 @default.
• W3185769050 cites W2131323933 @default.
• W3185769050 cites W2132259121 @default.
• W3185769050 cites W2132893883 @default.

• next