Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185778911> ?p ?o ?g. }
- W3185778911 abstract "SOX2 expression levels are crucial for the balance between maintenance and differentiation of airway progenitor cells during development and regeneration. Here, we describe patterning of the mouse proximal airway epithelium by SOX21, which coincides with high levels of SOX2 during development. Airway progenitor cells in this SOX2+/SOX21+ zone show differentiation to basal cells, specifying cells for the extrapulmonary airways. Loss of SOX21 showed an increased differentiation of SOX2+ progenitor cells to basal and ciliated cells during mouse lung development. We propose a mechanism where SOX21 inhibits differentiation of airway progenitors by antagonizing SOX2-induced expression of specific genes involved in airway differentiation. Additionally, in the adult tracheal epithelium, SOX21 inhibits basal to ciliated cell differentiation. This suppressing function of SOX21 on differentiation contrasts SOX2, which mainly drives differentiation of epithelial cells during development and regeneration after injury. Furthermore, using human fetal lung organoids and adult bronchial epithelial cells, we show that SOX2+/SOX21+ regionalization is conserved. Lastly, we show that the interplay between SOX2 and SOX21 is context and concentration dependent leading to regulation of differentiation of the airway epithelium." @default.
- W3185778911 created "2021-08-02" @default.
- W3185778911 creator A5006923711 @default.
- W3185778911 creator A5008042505 @default.
- W3185778911 creator A5010795557 @default.
- W3185778911 creator A5026235423 @default.
- W3185778911 creator A5033738196 @default.
- W3185778911 creator A5037857798 @default.
- W3185778911 creator A5045145492 @default.
- W3185778911 creator A5057888246 @default.
- W3185778911 creator A5073013772 @default.
- W3185778911 creator A5074642591 @default.
- W3185778911 date "2021-07-21" @default.
- W3185778911 modified "2023-09-26" @default.
- W3185778911 title "SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways" @default.
- W3185778911 cites W1555874196 @default.
- W3185778911 cites W1974523446 @default.
- W3185778911 cites W1977565596 @default.
- W3185778911 cites W1978782047 @default.
- W3185778911 cites W1985888836 @default.
- W3185778911 cites W1995758351 @default.
- W3185778911 cites W1999189368 @default.
- W3185778911 cites W2007413389 @default.
- W3185778911 cites W2007610579 @default.
- W3185778911 cites W2018647497 @default.
- W3185778911 cites W2024619217 @default.
- W3185778911 cites W2035222904 @default.
- W3185778911 cites W2038206131 @default.
- W3185778911 cites W2047628006 @default.
- W3185778911 cites W2050690137 @default.
- W3185778911 cites W2069534609 @default.
- W3185778911 cites W2070474424 @default.
- W3185778911 cites W2070939204 @default.
- W3185778911 cites W2073303427 @default.
- W3185778911 cites W2101554198 @default.
- W3185778911 cites W2117248052 @default.
- W3185778911 cites W2120379841 @default.
- W3185778911 cites W2122218449 @default.
- W3185778911 cites W2125806967 @default.
- W3185778911 cites W2131062818 @default.
- W3185778911 cites W2137644219 @default.
- W3185778911 cites W2142325605 @default.
- W3185778911 cites W2144777356 @default.
- W3185778911 cites W2158899370 @default.
- W3185778911 cites W2159545748 @default.
- W3185778911 cites W2170444631 @default.
- W3185778911 cites W2258682770 @default.
- W3185778911 cites W2291528962 @default.
- W3185778911 cites W2307567449 @default.
- W3185778911 cites W2732316774 @default.
- W3185778911 cites W2764254700 @default.
- W3185778911 cites W2788070727 @default.
- W3185778911 cites W2792932463 @default.
- W3185778911 cites W2795125292 @default.
- W3185778911 cites W2797828983 @default.
- W3185778911 cites W2799736418 @default.
- W3185778911 cites W2806505923 @default.
- W3185778911 cites W2885499809 @default.
- W3185778911 cites W2953029274 @default.
- W3185778911 cites W3025690520 @default.
- W3185778911 cites W3101697142 @default.
- W3185778911 doi "https://doi.org/10.7554/elife.57325" @default.
- W3185778911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8331192" @default.
- W3185778911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34286693" @default.
- W3185778911 hasPublicationYear "2021" @default.
- W3185778911 type Work @default.
- W3185778911 sameAs 3185778911 @default.
- W3185778911 citedByCount "10" @default.
- W3185778911 countsByYear W31857789112022 @default.
- W3185778911 countsByYear W31857789112023 @default.
- W3185778911 crossrefType "journal-article" @default.
- W3185778911 hasAuthorship W3185778911A5006923711 @default.
- W3185778911 hasAuthorship W3185778911A5008042505 @default.
- W3185778911 hasAuthorship W3185778911A5010795557 @default.
- W3185778911 hasAuthorship W3185778911A5026235423 @default.
- W3185778911 hasAuthorship W3185778911A5033738196 @default.
- W3185778911 hasAuthorship W3185778911A5037857798 @default.
- W3185778911 hasAuthorship W3185778911A5045145492 @default.
- W3185778911 hasAuthorship W3185778911A5057888246 @default.
- W3185778911 hasAuthorship W3185778911A5073013772 @default.
- W3185778911 hasAuthorship W3185778911A5074642591 @default.
- W3185778911 hasBestOaLocation W31857789111 @default.
- W3185778911 hasConcept C104317684 @default.
- W3185778911 hasConcept C145103041 @default.
- W3185778911 hasConcept C148738053 @default.
- W3185778911 hasConcept C15729860 @default.
- W3185778911 hasConcept C171056886 @default.
- W3185778911 hasConcept C201750760 @default.
- W3185778911 hasConcept C2777933648 @default.
- W3185778911 hasConcept C28328180 @default.
- W3185778911 hasConcept C529295009 @default.
- W3185778911 hasConcept C54355233 @default.
- W3185778911 hasConcept C86803240 @default.
- W3185778911 hasConcept C87568996 @default.
- W3185778911 hasConcept C95444343 @default.
- W3185778911 hasConceptScore W3185778911C104317684 @default.
- W3185778911 hasConceptScore W3185778911C145103041 @default.
- W3185778911 hasConceptScore W3185778911C148738053 @default.
- W3185778911 hasConceptScore W3185778911C15729860 @default.
- W3185778911 hasConceptScore W3185778911C171056886 @default.