Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185799207> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3185799207 endingPage "252" @default.
- W3185799207 startingPage "248" @default.
- W3185799207 abstract "Abstract Objective Rituximab (RTX) is a monoclonal antibody directed against CD20 epitope expressed on B cells used widely in neuromyelitis optica spectrum disorder (NMOsd). There are few studies evaluating anti‐aquaporin‐4 (AQP4) positive‐to‐negative seroconversion. In this series, we evaluated this phenomenon in a Latin American population. Methods A retrospective, longitudinal and analytic study was carried out in 19 AQP4 immunoglobulin G (IgG) + NMOsd patients. We monitored all patients with a yearly test for AQP4‐IgG serum autoantibodies. Potential relationships between negative seroconversion and annualized relapse rate, Expanded Disability Status Scale score, immunosuppressive or immunoregulatory treatment were assessed. Results We included 19 patients, 17 (89.5%) were women. The mean Expanded Disability Status Scale score and annualized relapse rate at clinical onset was 3.8 (±1.97) and 0.81 (±0.577), respectively. Disease‐modifying treatment included RTX, cyclophosphamide, azathioprine and methotrexate. We documented positive‐to‐negative seroconversion in six of the patients in the RTX group ( P = 0.047). No significant changes were observed in the annualized relapse rate (2.11 vs 1.88, P = 0.06) or Expanded Disability Status Scale scores (4.41 vs 3.1, P = 0.25) between the group of seroconverted patients from those who remained positive. Conclusions Treatment with RTX in patients with seropositive AQP4‐IgG NMOsd can lead to negative conversion, but our findings do not support a clinical reflection from this change. The role of monitoring for AQP4‐IgG is yet to be defined in the Mexican NMOsd population." @default.
- W3185799207 created "2021-08-02" @default.
- W3185799207 creator A5002563577 @default.
- W3185799207 creator A5010604563 @default.
- W3185799207 creator A5014821792 @default.
- W3185799207 creator A5018115500 @default.
- W3185799207 creator A5018285186 @default.
- W3185799207 creator A5018350781 @default.
- W3185799207 creator A5023287441 @default.
- W3185799207 creator A5033609796 @default.
- W3185799207 creator A5051838149 @default.
- W3185799207 creator A5085788059 @default.
- W3185799207 date "2021-08-20" @default.
- W3185799207 modified "2023-09-23" @default.
- W3185799207 title "Anti‐aquaporin‐4 positive‐to‐negative seroconversion in Latin American patients with neuromyelitis optica spectrum disorder treated with rituximab" @default.
- W3185799207 cites W1893466103 @default.
- W3185799207 cites W2072799381 @default.
- W3185799207 cites W2110846578 @default.
- W3185799207 cites W2120238028 @default.
- W3185799207 cites W2129229339 @default.
- W3185799207 cites W2278851035 @default.
- W3185799207 cites W2561708624 @default.
- W3185799207 cites W2746200202 @default.
- W3185799207 cites W2791305328 @default.
- W3185799207 cites W2908825776 @default.
- W3185799207 cites W2942594179 @default.
- W3185799207 cites W2978077412 @default.
- W3185799207 cites W3028777890 @default.
- W3185799207 doi "https://doi.org/10.1111/cen3.12664" @default.
- W3185799207 hasPublicationYear "2021" @default.
- W3185799207 type Work @default.
- W3185799207 sameAs 3185799207 @default.
- W3185799207 citedByCount "0" @default.
- W3185799207 crossrefType "journal-article" @default.
- W3185799207 hasAuthorship W3185799207A5002563577 @default.
- W3185799207 hasAuthorship W3185799207A5010604563 @default.
- W3185799207 hasAuthorship W3185799207A5014821792 @default.
- W3185799207 hasAuthorship W3185799207A5018115500 @default.
- W3185799207 hasAuthorship W3185799207A5018285186 @default.
- W3185799207 hasAuthorship W3185799207A5018350781 @default.
- W3185799207 hasAuthorship W3185799207A5023287441 @default.
- W3185799207 hasAuthorship W3185799207A5033609796 @default.
- W3185799207 hasAuthorship W3185799207A5051838149 @default.
- W3185799207 hasAuthorship W3185799207A5085788059 @default.
- W3185799207 hasConcept C126322002 @default.
- W3185799207 hasConcept C159654299 @default.
- W3185799207 hasConcept C163764329 @default.
- W3185799207 hasConcept C203014093 @default.
- W3185799207 hasConcept C2776694085 @default.
- W3185799207 hasConcept C2776755627 @default.
- W3185799207 hasConcept C2776760755 @default.
- W3185799207 hasConcept C2777451964 @default.
- W3185799207 hasConcept C2779134260 @default.
- W3185799207 hasConcept C2780640218 @default.
- W3185799207 hasConcept C2780653079 @default.
- W3185799207 hasConcept C2780892749 @default.
- W3185799207 hasConcept C2781137167 @default.
- W3185799207 hasConcept C2908647359 @default.
- W3185799207 hasConcept C71924100 @default.
- W3185799207 hasConcept C90924648 @default.
- W3185799207 hasConcept C99454951 @default.
- W3185799207 hasConceptScore W3185799207C126322002 @default.
- W3185799207 hasConceptScore W3185799207C159654299 @default.
- W3185799207 hasConceptScore W3185799207C163764329 @default.
- W3185799207 hasConceptScore W3185799207C203014093 @default.
- W3185799207 hasConceptScore W3185799207C2776694085 @default.
- W3185799207 hasConceptScore W3185799207C2776755627 @default.
- W3185799207 hasConceptScore W3185799207C2776760755 @default.
- W3185799207 hasConceptScore W3185799207C2777451964 @default.
- W3185799207 hasConceptScore W3185799207C2779134260 @default.
- W3185799207 hasConceptScore W3185799207C2780640218 @default.
- W3185799207 hasConceptScore W3185799207C2780653079 @default.
- W3185799207 hasConceptScore W3185799207C2780892749 @default.
- W3185799207 hasConceptScore W3185799207C2781137167 @default.
- W3185799207 hasConceptScore W3185799207C2908647359 @default.
- W3185799207 hasConceptScore W3185799207C71924100 @default.
- W3185799207 hasConceptScore W3185799207C90924648 @default.
- W3185799207 hasConceptScore W3185799207C99454951 @default.
- W3185799207 hasIssue "4" @default.
- W3185799207 hasLocation W31857992071 @default.
- W3185799207 hasOpenAccess W3185799207 @default.
- W3185799207 hasPrimaryLocation W31857992071 @default.
- W3185799207 hasRelatedWork W152659163 @default.
- W3185799207 hasRelatedWork W1859082783 @default.
- W3185799207 hasRelatedWork W2009114633 @default.
- W3185799207 hasRelatedWork W2014893669 @default.
- W3185799207 hasRelatedWork W2132820210 @default.
- W3185799207 hasRelatedWork W2150598981 @default.
- W3185799207 hasRelatedWork W2625404774 @default.
- W3185799207 hasRelatedWork W2922203913 @default.
- W3185799207 hasRelatedWork W3212403324 @default.
- W3185799207 hasRelatedWork W4249342726 @default.
- W3185799207 hasVolume "12" @default.
- W3185799207 isParatext "false" @default.
- W3185799207 isRetracted "false" @default.
- W3185799207 magId "3185799207" @default.
- W3185799207 workType "article" @default.