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- W3185806720 abstract "Melanoma is the deadliest form of skin cancer. While clinical developments have significantly improved patient prognosis, effective treatment is often obstructed by limited response rates, intrinsic or acquired resistance to therapy, and adverse events. Melanoma initiation and progression are associated with transcriptional reprogramming of melanocytes to a cell state that resembles the lineage from which the cells are specified during development, that is the neural crest. Convergence to a neural crest cell (NCC)-like state revealed the therapeutic potential of targeting developmental pathways for the treatment of melanoma. Neural crest cells have a unique sensitivity to metabolic dysregulation, especially nucleotide depletion. Mutations in the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH) particularly affect neural crest-derived tissues and cause Miller syndrome, a genetic disorder characterized by craniofacial malformations in patients. The developmental susceptibility of the neural crest to nucleotide deficiency is conserved in melanoma and provides a metabolic vulnerability that can be exploited for therapeutic purposes. We review the current knowledge on nucleotide stress responses in neural crest and melanoma and discuss how the recent scientific advances that have improved our understanding of transcriptional regulation during nucleotide depletion can impact melanoma treatment." @default.
- W3185806720 created "2021-08-02" @default.
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- W3185806720 date "2021-07-19" @default.
- W3185806720 modified "2023-10-16" @default.
- W3185806720 title "Nucleotide stress responses in neural crest cell fate and melanoma" @default.
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- W3185806720 cites W1981378173 @default.
- W3185806720 cites W1982789056 @default.
- W3185806720 cites W1985577088 @default.
- W3185806720 cites W1994110056 @default.
- W3185806720 cites W1997889534 @default.
- W3185806720 cites W2009826707 @default.
- W3185806720 cites W2015068085 @default.
- W3185806720 cites W2017099874 @default.
- W3185806720 cites W2020099265 @default.
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- W3185806720 cites W2022936085 @default.
- W3185806720 cites W2028098820 @default.
- W3185806720 cites W2035913145 @default.
- W3185806720 cites W2035939293 @default.
- W3185806720 cites W2036210716 @default.
- W3185806720 cites W2037208965 @default.
- W3185806720 cites W2049370771 @default.
- W3185806720 cites W2051598492 @default.
- W3185806720 cites W2051718122 @default.
- W3185806720 cites W2053011686 @default.
- W3185806720 cites W2057650061 @default.
- W3185806720 cites W2064210252 @default.
- W3185806720 cites W2065343028 @default.
- W3185806720 cites W2067134023 @default.
- W3185806720 cites W2069202451 @default.
- W3185806720 cites W2080584000 @default.
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- W3185806720 cites W2140854963 @default.
- W3185806720 cites W2148252804 @default.
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- W3185806720 cites W2330148258 @default.
- W3185806720 cites W2331736295 @default.
- W3185806720 cites W2342564029 @default.
- W3185806720 cites W2531506996 @default.
- W3185806720 cites W2577479893 @default.
- W3185806720 cites W2586749844 @default.
- W3185806720 cites W2604316693 @default.
- W3185806720 cites W2605743056 @default.
- W3185806720 cites W2610181528 @default.
- W3185806720 cites W2743149369 @default.
- W3185806720 cites W2763578259 @default.
- W3185806720 cites W2765356256 @default.
- W3185806720 cites W2765597781 @default.
- W3185806720 cites W2777388101 @default.
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- W3185806720 doi "https://doi.org/10.1080/15384101.2021.1947567" @default.
- W3185806720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8354612" @default.
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