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• W3185848952 abstract "Treatment options for COVID-19, a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, are currently severely limited. Therefore, antiviral drugs that efficiently reduce SARS-CoV-2 replication or alleviate COVID-19 symptoms are urgently needed. Inhaled glucocorticoids are currently being discussed in the context of treatment for COVID-19, partly based on a previous study that reported reduced recovery times in cases of mild COVID-19 after inhalative administration of the glucocorticoid budesonide. Given various reports that describe the potential antiviral activity of glucocorticoids against respiratory viruses, we aimed to analyze a potential antiviral activity of budesonide against SARS-CoV-2 and circulating variants of concern (VOC) B.1.1.7 (alpha) and B.1.351 (beta). We demonstrate a dose-dependent inhibition of SARS-CoV-2 that was comparable between all viral variants tested while cell viability remains unaffected. Our results are encouraging as they could indicate a multimodal mode of action of budesonide against SARS-CoV-2 and COVID-19, which could contribute to an improved clinical performance." @default.
• W3185848952 created "2021-08-02" @default.
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• W3185848952 date "2021-07-20" @default.
• W3185848952 modified "2023-10-08" @default.
• W3185848952 title "Antiviral Effect of Budesonide against SARS-CoV-2" @default.
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• W3185848952 doi "https://doi.org/10.3390/v13071411" @default.
• W3185848952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8310374" @default.
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