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- W3185888932 endingPage "8021" @default.
- W3185888932 startingPage "8021" @default.
- W3185888932 abstract "Since the emergence of high-throughput proteomic techniques and advances in clinical technologies, there has been a steady rise in the number of cancer-associated diagnostic, prognostic, and predictive biomarkers being identified and translated into clinical use. The characterisation of biofluids has become a core objective for many proteomic researchers in order to detect disease-associated protein biomarkers in a minimally invasive manner. The proteomes of biofluids, including serum, saliva, cerebrospinal fluid, and urine, are highly dynamic with protein abundance fluctuating depending on the physiological and/or pathophysiological context. Improvements in mass-spectrometric technologies have facilitated the in-depth characterisation of biofluid proteomes which are now considered hosts of a wide array of clinically relevant biomarkers. Promising efforts are being made in the field of biomarker diagnostics for haematologic malignancies. Several serum and urine-based biomarkers such as free light chains, β-microglobulin, and lactate dehydrogenase are quantified as part of the clinical assessment of haematological malignancies. However, novel, minimally invasive proteomic markers are required to aid diagnosis and prognosis and to monitor therapeutic response and minimal residual disease. This review focuses on biofluids as a promising source of proteomic biomarkers in haematologic malignancies and a key component of future diagnostic, prognostic, and disease-monitoring applications." @default.
- W3185888932 created "2021-08-02" @default.
- W3185888932 creator A5005968329 @default.
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- W3185888932 creator A5045330640 @default.
- W3185888932 creator A5049451037 @default.
- W3185888932 creator A5061878557 @default.
- W3185888932 date "2021-07-27" @default.
- W3185888932 modified "2023-10-16" @default.
- W3185888932 title "Clinical Proteomics of Biofluids in Haematological Malignancies" @default.
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