FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3185973224> ?p ?o ?g. }

• W3185973224 endingPage "687" @default.
• W3185973224 startingPage "675" @default.
• W3185973224 abstract "Steroids and insulin-like growth factors (Igfs) are indispensable for folliculogenesis and reproductive fitness in the vertebrate ovary. The intrafollicular redox balance is also of immense importance for ovarian follicles wherein low levels of ROS are being utilized for cell signalling and regulation of gene expression; its excess may interfere with normal physiological processes leading to ovotoxicity. However, the functional relevance of ovarian steroidogenesis in maintaining the follicular microenvironment with coordinated redox homeostasis and intra-ovarian growth factors axis is relatively less understood. Using zebrafish full-grown (FG) ovarian follicles in vitro, our study shows that blocking steroid biosynthesis with anti-steroidal drugs, DL-aminoglutethimide (AG) or Trilostane (Trilo), prevents hCG (LH analogue)-induced StAR expression concomitant with a robust increase in intrafollicular ROS levels. Congruent with heightened intracellular levels of superoxide anions (O2•–) and hydrogen peroxide (H2O2), priming with AG or Trilo abrogates the transcript abundance of major antioxidant enzyme genes (SOD1, SOD2, and CAT) in hCG-stimulated follicles. Significantly, blocking steroidogenesis attenuates transcript abundance of HSP70 but elevates NOX4 expression potentially through ERα-mediated pathway. Importantly, disrupted redox balance in AG/Trilo pre-incubated FG follicles negatively impacts hCG-mediated activation of PKA/CREB signaling and transcriptional activation of igf ligands. Elevated ROS attenuation of antioxidant defense parameters and impaired endocrine and autocrine/paracrine homeostasis converge upon reduced p34cdc2 (Thr-161) phosphorylation, a reliable marker for MPF activation, and resumption of meiotic G2-M1 transition in hCG-treated follicles. Collectively, altered redox homeostasis in steroid-depleted follicles has a significant negative influence on GTH (LH) regulation of follicular events, specifically Igf synthesis, meiotic maturational competence and ovarian fitness." @default.
• W3185973224 created "2021-08-02" @default.
• W3185973224 creator A5047328899 @default.
• W3185973224 creator A5063306889 @default.
• W3185973224 date "2021-08-01" @default.
• W3185973224 modified "2023-10-11" @default.
• W3185973224 title "Altered redox homeostasis in steroid-depleted follicles attenuates hCG regulation of follicular events: Cross-talk between endocrine and IGF axis in maturing oocytes" @default.
• W3185973224 cites W1971727708 @default.
• W3185973224 cites W1982999142 @default.
• W3185973224 cites W1983076004 @default.
• W3185973224 cites W1988230895 @default.
• W3185973224 cites W1993554231 @default.
• W3185973224 cites W1997684038 @default.
• W3185973224 cites W2008885463 @default.
• W3185973224 cites W2011964721 @default.
• W3185973224 cites W2013257770 @default.
• W3185973224 cites W2015568979 @default.
• W3185973224 cites W2019470807 @default.
• W3185973224 cites W2034969930 @default.
• W3185973224 cites W2036615909 @default.
• W3185973224 cites W2045281985 @default.
• W3185973224 cites W2049169526 @default.
• W3185973224 cites W2050834494 @default.
• W3185973224 cites W2051018779 @default.
• W3185973224 cites W2062174925 @default.
• W3185973224 cites W2062430151 @default.
• W3185973224 cites W2062551965 @default.
• W3185973224 cites W2066371634 @default.
• W3185973224 cites W2067642579 @default.
• W3185973224 cites W2072275540 @default.
• W3185973224 cites W2077775271 @default.
• W3185973224 cites W2083084721 @default.
• W3185973224 cites W2084983662 @default.
• W3185973224 cites W2086121206 @default.
• W3185973224 cites W2094745170 @default.
• W3185973224 cites W2102423272 @default.
• W3185973224 cites W2104256886 @default.
• W3185973224 cites W2107277218 @default.
• W3185973224 cites W2108745700 @default.
• W3185973224 cites W2111527664 @default.
• W3185973224 cites W2119937630 @default.
• W3185973224 cites W2124080367 @default.
• W3185973224 cites W2126722856 @default.
• W3185973224 cites W2127208573 @default.
• W3185973224 cites W2150837319 @default.
• W3185973224 cites W2160848231 @default.
• W3185973224 cites W2164448788 @default.
• W3185973224 cites W2164507972 @default.
• W3185973224 cites W2166500798 @default.
• W3185973224 cites W2176931687 @default.
• W3185973224 cites W2253261722 @default.
• W3185973224 cites W2268893908 @default.
• W3185973224 cites W2340180600 @default.
• W3185973224 cites W2412776540 @default.
• W3185973224 cites W2484327514 @default.
• W3185973224 cites W2556696389 @default.
• W3185973224 cites W2564046293 @default.
• W3185973224 cites W2618142594 @default.
• W3185973224 cites W2758615758 @default.
• W3185973224 cites W2792375985 @default.
• W3185973224 cites W2921949390 @default.
• W3185973224 cites W2964168670 @default.
• W3185973224 cites W2971564786 @default.
• W3185973224 cites W3002456591 @default.
• W3185973224 cites W3036217148 @default.
• W3185973224 cites W3047136069 @default.
• W3185973224 cites W3048364937 @default.
• W3185973224 cites W3087205938 @default.
• W3185973224 doi "https://doi.org/10.1016/j.freeradbiomed.2021.07.023" @default.
• W3185973224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34289395" @default.
• W3185973224 hasPublicationYear "2021" @default.
• W3185973224 type Work @default.
• W3185973224 sameAs 3185973224 @default.
• W3185973224 citedByCount "5" @default.
• W3185973224 countsByYear W31859732242022 @default.
• W3185973224 countsByYear W31859732242023 @default.
• W3185973224 crossrefType "journal-article" @default.
• W3185973224 hasAuthorship W3185973224A5047328899 @default.
• W3185973224 hasAuthorship W3185973224A5063306889 @default.
• W3185973224 hasConcept C126322002 @default.
• W3185973224 hasConcept C128240485 @default.
• W3185973224 hasConcept C134018914 @default.
• W3185973224 hasConcept C170493617 @default.
• W3185973224 hasConcept C179933525 @default.
• W3185973224 hasConcept C185592680 @default.
• W3185973224 hasConcept C187785154 @default.
• W3185973224 hasConcept C196843134 @default.
• W3185973224 hasConcept C2775838275 @default.
• W3185973224 hasConcept C2776108821 @default.
• W3185973224 hasConcept C2776151105 @default.
• W3185973224 hasConcept C2780536345 @default.
• W3185973224 hasConcept C5512455 @default.
• W3185973224 hasConcept C63645605 @default.
• W3185973224 hasConcept C71924100 @default.
• W3185973224 hasConcept C7876069 @default.
• W3185973224 hasConcept C86803240 @default.
• W3185973224 hasConcept C95444343 @default.
• W3185973224 hasConceptScore W3185973224C126322002 @default.

• next