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• W3186017652 endingPage "105003" @default.
• W3186017652 startingPage "105003" @default.
• W3186017652 abstract "The wound bacterial infections have become an intractable problem to human health. Multifunctional wound dressing materials with excellent adhesion, antibacterial as well as wound healing properties are still desperately needed to resist wound infection. In this work, an injectable hydrogel has been prepared, which chitosan and hyaluronic acid were cross-linked by aldehyde modified polyethylene glycol (PEG). For improving the antibacterial property, S-nitrosothiols was used as nitric oxide (NO) donor to provide a sustained NO release. The gelation time, microstructure, pH responsiveness, injectability, self-healing property as well as NO release profile were characterized. Quick and efficient antibacterial potency towards E. coli and S. epidermidis was confirmed in vitro with contact-killing assays. The co-culturing experiment with NIH 3 T3, HFF-1 and bEnd.3 cells indicated excellent biocompatibility of the hydrogels. Most importantly, the hydrogels showed the ability to accelerate the cell migration, demonstrating a potential to promote wound healing by scratch-wound assay. The current work provided a new type of injectable self-healing hydrogel for antibacterial function and infectious skin repair, leading to great potentials for infected wound healing. • The NO donor containing hydrogels showed an effective antibacterial ability and a fast-antibacterial rate. • The injectable property of the hydrogels is beneficial to the therapy of irregular and deep wound. • The self-healing property of the hydrogels can reduce the secondary damage in debridement and improve patient compliance." @default.
• W3186017652 created "2021-08-02" @default.
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• W3186017652 date "2021-09-01" @default.
• W3186017652 modified "2023-10-01" @default.
• W3186017652 title "Injectable and self-healing hydrogel containing nitric oxide donor for enhanced antibacterial activity" @default.
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• W3186017652 doi "https://doi.org/10.1016/j.reactfunctpolym.2021.105003" @default.
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