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• W3186085011 abstract "Abstract Pathogenic Leptospira species cause leptospirosis, a neglected zoonotic disease recognized as a global public health problem. It is also the cause of the most common cattle infection that results in major economic losses due to reproductive problems. γδ T cells play a role in the protective immune response in livestock species against Leptospira while human γδ T cells also respond to Leptospira . Thus, activation of γδ T cells has emerged as a potential component for optimization of vaccine strategies. Bovine γδ T cells proliferate and produce IFN-γ in response to vaccination with inactivated leptospires and this response is mediated by a specific subpopulation of the WC1-bearing γδ T cells. WC1 molecules are members of the group B scavenger receptor cysteine rich (SRCR) superfamily and are composed of multiple SRCR domains, of which particular extracellular domains act as ligands for Leptospira . Since WC1 molecules function as both pattern recognition receptors and γδ TCR coreceptors, the WC1 system has been proposed as a novel target to engage γδ T cells. Here, we demonstrate the involvement of leptospiral protein antigens in the activation of WC1 + γδ T cells and identified two leptospiral outer membrane proteins able to interact directly with them. Interestingly, we show that the protein-specific γδ T cell response is composed of WC1.1 + and WC1.2 + subsets, although a greater number of WC1.1 + γδ T cells respond. Identification of protein antigens will enhance our understanding of the role γδ T cells play in the leptospiral immune response and in recombinant vaccine development." @default.
• W3186085011 created "2021-08-02" @default.
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• W3186085011 date "2021-07-17" @default.
• W3186085011 modified "2023-10-15" @default.
• W3186085011 title "Identification of leptospiral protein antigens recognized by WC1+γδ T cell subsets as target for development of recombinant vaccines" @default.
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• W3186085011 doi "https://doi.org/10.1101/2021.07.16.452762" @default.
• W3186085011 hasPublicationYear "2021" @default.
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