Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186092929> ?p ?o ?g. }
- W3186092929 abstract "Abstract Taller people have lower risk of coronary heart disease but higher risk of many cancers. Mendelian randomization studies in unrelated individuals have suggested that these relationships are potentially causal. However, Mendelian randomization estimates from samples of unrelated individuals are sensitive to demography (population stratification, assortative mating) and familial (indirect genetic) effects. Height could influence disease risk via anatomic and physiological effects of height (e.g., number of cells or the bore of arteries) or previous results may have been confounded by early-life environmental factors (e.g., parental socioeconomic position and nutrition). In this study, we performed within-sibship Mendelian randomization analyses using 77,757 siblings, a design robust against demography and indirect genetic effects of parents. Within-sibship Mendelian randomization estimated that one SD taller height lowers odds of coronary heart disease by 14% (95% CI: 3% to 23%) but increases odds of cancer by 18% (95% CI: 3% to 34%). There was some evidence that taller height reduces systolic blood pressure and LDL cholesterol, which may mediate some of the protective effect of taller height on coronary heart disease risk. For the first time, we have demonstrated that purported effects of height on adulthood disease risk are unlikely to be explained by demographic or familial factors, and so likely reflect an individual-level causal effect. Disentangling the mechanisms via which height affects disease risk may improve understanding of the aetiologies of atherosclerosis and carcinogenesis." @default.
- W3186092929 created "2021-08-02" @default.
- W3186092929 creator A5004532085 @default.
- W3186092929 creator A5023038797 @default.
- W3186092929 creator A5048398431 @default.
- W3186092929 creator A5064287149 @default.
- W3186092929 creator A5069421607 @default.
- W3186092929 creator A5076124471 @default.
- W3186092929 creator A5081189884 @default.
- W3186092929 date "2021-07-19" @default.
- W3186092929 modified "2023-10-17" @default.
- W3186092929 title "Taller height and risk of coronary heart disease and cancer: a within-sibship Mendelian randomization study" @default.
- W3186092929 cites W1504564443 @default.
- W3186092929 cites W1600041372 @default.
- W3186092929 cites W1773772953 @default.
- W3186092929 cites W1907868928 @default.
- W3186092929 cites W1972696558 @default.
- W3186092929 cites W1996938411 @default.
- W3186092929 cites W2031970633 @default.
- W3186092929 cites W2046736790 @default.
- W3186092929 cites W2048672426 @default.
- W3186092929 cites W2066313554 @default.
- W3186092929 cites W2069115947 @default.
- W3186092929 cites W2075674224 @default.
- W3186092929 cites W2082704080 @default.
- W3186092929 cites W2093922076 @default.
- W3186092929 cites W2102213696 @default.
- W3186092929 cites W2102309722 @default.
- W3186092929 cites W2104005681 @default.
- W3186092929 cites W2104549677 @default.
- W3186092929 cites W2106036991 @default.
- W3186092929 cites W2111843196 @default.
- W3186092929 cites W2116404316 @default.
- W3186092929 cites W2116886985 @default.
- W3186092929 cites W2129465958 @default.
- W3186092929 cites W2134049753 @default.
- W3186092929 cites W2135255861 @default.
- W3186092929 cites W2139466130 @default.
- W3186092929 cites W2139852278 @default.
- W3186092929 cites W2141405148 @default.
- W3186092929 cites W2147873201 @default.
- W3186092929 cites W2149923640 @default.
- W3186092929 cites W2156149042 @default.
- W3186092929 cites W2161382132 @default.
- W3186092929 cites W2161633633 @default.
- W3186092929 cites W2162154276 @default.
- W3186092929 cites W2169163226 @default.
- W3186092929 cites W2267977281 @default.
- W3186092929 cites W2271460141 @default.
- W3186092929 cites W2295447825 @default.
- W3186092929 cites W2302050055 @default.
- W3186092929 cites W2305947592 @default.
- W3186092929 cites W2415473920 @default.
- W3186092929 cites W2510973425 @default.
- W3186092929 cites W2511515754 @default.
- W3186092929 cites W2579779633 @default.
- W3186092929 cites W2752425944 @default.
- W3186092929 cites W2770085798 @default.
- W3186092929 cites W2794196479 @default.
- W3186092929 cites W2883573930 @default.
- W3186092929 cites W2886507777 @default.
- W3186092929 cites W2895486342 @default.
- W3186092929 cites W2900137720 @default.
- W3186092929 cites W2910199421 @default.
- W3186092929 cites W2923400604 @default.
- W3186092929 cites W2924359406 @default.
- W3186092929 cites W2925038939 @default.
- W3186092929 cites W2938667012 @default.
- W3186092929 cites W2952596949 @default.
- W3186092929 cites W2981338841 @default.
- W3186092929 cites W3012912937 @default.
- W3186092929 cites W3098524204 @default.
- W3186092929 cites W3134758003 @default.
- W3186092929 cites W4210703904 @default.
- W3186092929 doi "https://doi.org/10.1101/2021.07.16.21260639" @default.
- W3186092929 hasPublicationYear "2021" @default.
- W3186092929 type Work @default.
- W3186092929 sameAs 3186092929 @default.
- W3186092929 citedByCount "0" @default.
- W3186092929 crossrefType "posted-content" @default.
- W3186092929 hasAuthorship W3186092929A5004532085 @default.
- W3186092929 hasAuthorship W3186092929A5023038797 @default.
- W3186092929 hasAuthorship W3186092929A5048398431 @default.
- W3186092929 hasAuthorship W3186092929A5064287149 @default.
- W3186092929 hasAuthorship W3186092929A5069421607 @default.
- W3186092929 hasAuthorship W3186092929A5076124471 @default.
- W3186092929 hasAuthorship W3186092929A5081189884 @default.
- W3186092929 hasBestOaLocation W31860929291 @default.
- W3186092929 hasConcept C104317684 @default.
- W3186092929 hasConcept C126322002 @default.
- W3186092929 hasConcept C135763542 @default.
- W3186092929 hasConcept C144024400 @default.
- W3186092929 hasConcept C149923435 @default.
- W3186092929 hasConcept C156957248 @default.
- W3186092929 hasConcept C168563851 @default.
- W3186092929 hasConcept C204243189 @default.
- W3186092929 hasConcept C2777433574 @default.
- W3186092929 hasConcept C2779134260 @default.
- W3186092929 hasConcept C2779901538 @default.
- W3186092929 hasConcept C2908647359 @default.