Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186104766> ?p ?o ?g. }
- W3186104766 endingPage "12" @default.
- W3186104766 startingPage "1" @default.
- W3186104766 abstract "Systemic lupus erythematosus (SLE) is an autoimmune-mediated diffuse connective tissue disease characterized by immune inflammation with an unclear aetiology and pathogenesis. This work profiled the intestinal flora and faecal metabolome of patients with SLE using 16S RNA sequencing and gas chromatography-mass spectrometry (GC-MS). We identified unchanged alpha diversity and partially altered beta diversity of the intestinal flora. Another important finding was the increase in Proteobacteria and Enterobacteriales and the decrease in Ruminococcaceae among SLE patients. For metabolites, amino acids and short-chain fatty acids were enriched when long-chain fatty acids were downregulated in SLE faecal samples. KEGG analysis showed the significance of the protein digestion and absorption pathway, and association analysis revealed the key role of 3-phenylpropanoic acid and Sphingomonas. Sphingomonas were reported to be less abundant in healthy periodontal sites of SLE patients than in those of HCs, indicating transmission of oral species to the gut. This study contributes to the understanding of the pathogenesis of SLE disease from the perspective of intestinal microorganisms, explains the pathogenesis of SLE, and serves as a basis for exploring potential treatments for the disease." @default.
- W3186104766 created "2021-08-02" @default.
- W3186104766 creator A5000934098 @default.
- W3186104766 creator A5013279147 @default.
- W3186104766 creator A5016444946 @default.
- W3186104766 creator A5037039731 @default.
- W3186104766 creator A5039733512 @default.
- W3186104766 creator A5041526853 @default.
- W3186104766 creator A5054267674 @default.
- W3186104766 creator A5059971691 @default.
- W3186104766 creator A5066061403 @default.
- W3186104766 creator A5076933910 @default.
- W3186104766 creator A5078148917 @default.
- W3186104766 creator A5083157583 @default.
- W3186104766 creator A5089079624 @default.
- W3186104766 date "2021-07-23" @default.
- W3186104766 modified "2023-10-12" @default.
- W3186104766 title "Correlation Analysis between Gut Microbiota and Metabolites in Children with Systemic Lupus Erythematosus" @default.
- W3186104766 cites W1647551795 @default.
- W3186104766 cites W1974174091 @default.
- W3186104766 cites W1975308719 @default.
- W3186104766 cites W1988578259 @default.
- W3186104766 cites W1992444121 @default.
- W3186104766 cites W2031611770 @default.
- W3186104766 cites W2070527591 @default.
- W3186104766 cites W2091545272 @default.
- W3186104766 cites W2105719699 @default.
- W3186104766 cites W2117040192 @default.
- W3186104766 cites W2133169528 @default.
- W3186104766 cites W2138007859 @default.
- W3186104766 cites W2290702494 @default.
- W3186104766 cites W2413004278 @default.
- W3186104766 cites W2482013437 @default.
- W3186104766 cites W2491155763 @default.
- W3186104766 cites W2559999430 @default.
- W3186104766 cites W2591193214 @default.
- W3186104766 cites W2598798043 @default.
- W3186104766 cites W2601011344 @default.
- W3186104766 cites W2615916304 @default.
- W3186104766 cites W2625419804 @default.
- W3186104766 cites W2754064064 @default.
- W3186104766 cites W2774400912 @default.
- W3186104766 cites W2792021903 @default.
- W3186104766 cites W2795295085 @default.
- W3186104766 cites W2805972698 @default.
- W3186104766 cites W2892133680 @default.
- W3186104766 cites W2898199093 @default.
- W3186104766 cites W2898577183 @default.
- W3186104766 cites W2921305588 @default.
- W3186104766 cites W2949284538 @default.
- W3186104766 cites W2964854557 @default.
- W3186104766 cites W2966041078 @default.
- W3186104766 cites W3016889019 @default.
- W3186104766 cites W3041219042 @default.
- W3186104766 cites W3046310046 @default.
- W3186104766 cites W3085164882 @default.
- W3186104766 cites W3095375964 @default.
- W3186104766 cites W3098286627 @default.
- W3186104766 doi "https://doi.org/10.1155/2021/5579608" @default.
- W3186104766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8325587" @default.
- W3186104766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34341764" @default.
- W3186104766 hasPublicationYear "2021" @default.
- W3186104766 type Work @default.
- W3186104766 sameAs 3186104766 @default.
- W3186104766 citedByCount "22" @default.
- W3186104766 countsByYear W31861047662021 @default.
- W3186104766 countsByYear W31861047662022 @default.
- W3186104766 countsByYear W31861047662023 @default.
- W3186104766 crossrefType "journal-article" @default.
- W3186104766 hasAuthorship W3186104766A5000934098 @default.
- W3186104766 hasAuthorship W3186104766A5013279147 @default.
- W3186104766 hasAuthorship W3186104766A5016444946 @default.
- W3186104766 hasAuthorship W3186104766A5037039731 @default.
- W3186104766 hasAuthorship W3186104766A5039733512 @default.
- W3186104766 hasAuthorship W3186104766A5041526853 @default.
- W3186104766 hasAuthorship W3186104766A5054267674 @default.
- W3186104766 hasAuthorship W3186104766A5059971691 @default.
- W3186104766 hasAuthorship W3186104766A5066061403 @default.
- W3186104766 hasAuthorship W3186104766A5076933910 @default.
- W3186104766 hasAuthorship W3186104766A5078148917 @default.
- W3186104766 hasAuthorship W3186104766A5083157583 @default.
- W3186104766 hasAuthorship W3186104766A5089079624 @default.
- W3186104766 hasBestOaLocation W31861047661 @default.
- W3186104766 hasConcept C126322002 @default.
- W3186104766 hasConcept C203014093 @default.
- W3186104766 hasConcept C2776912625 @default.
- W3186104766 hasConcept C2779134260 @default.
- W3186104766 hasConcept C2780942790 @default.
- W3186104766 hasConcept C539455810 @default.
- W3186104766 hasConcept C71924100 @default.
- W3186104766 hasConcept C86803240 @default.
- W3186104766 hasConcept C8891405 @default.
- W3186104766 hasConcept C89423630 @default.
- W3186104766 hasConceptScore W3186104766C126322002 @default.
- W3186104766 hasConceptScore W3186104766C203014093 @default.
- W3186104766 hasConceptScore W3186104766C2776912625 @default.
- W3186104766 hasConceptScore W3186104766C2779134260 @default.
- W3186104766 hasConceptScore W3186104766C2780942790 @default.