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• W3186105430 endingPage "120893" @default.
• W3186105430 startingPage "120893" @default.
• W3186105430 abstract "Orally inhaled products (OIPs) are gaining increased attention, as pulmonary delivery is a preferred route for the treatment of various diseases. Yet, the field of inhalation biopharmaceutics is still in development phase. For a successful correlation between various in vitro data obtained during formulation characterization and in vivo performance, it is necessary to understand the impact of parameters such as solubility and dissolution of drugs. In this work, we used in vitro-in silico feedback-feedforward approach to gain a better insight into the biopharmaceutics behavior of inhaled Salbutamol Sulphate (SS) and Budesonide (BUD). The thorough characterization of the in vitro test media and the impact of different in vitro fluid components such as lipids and protein on the solubility of aforementioned drugs was studied . These results were subsequently used as an input into the developed in silico models to investigate potential PK parameter changes in vivo . Results revealed that media comprising lipids and albumin were the most biorelevant and impacted the solubility of BUD the most. On the contrary, no notable impact was seen in case of SS. The use of simple media such as phosphate buffer saline (PBS) might be sufficient to use in solubility studies of the highly soluble and permeable drugs. However, its use for the poorly soluble drugs is limited due to the greater potential for interactions within in vivo environment. The use of in silico tools showed that the model response varies, depending on the used media. Therefore, this work highlights the relevance of carefully selecting the media composition when investigating solubility and dissolution behavior, especially in the early phases of drug development and of poorly soluble drugs." @default.
• W3186105430 created "2021-08-02" @default.
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• W3186105430 date "2021-09-01" @default.
• W3186105430 modified "2023-10-16" @default.
• W3186105430 title "Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance" @default.
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• W3186105430 doi "https://doi.org/10.1016/j.ijpharm.2021.120893" @default.
• W3186105430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34274456" @default.
• W3186105430 hasPublicationYear "2021" @default.
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