FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186108779> ?p ?o ?g. }

• W3186108779 endingPage "239784732110210" @default.
• W3186108779 startingPage "239784732110210" @default.
• W3186108779 abstract "The objectives of this study were to increase PG exposure above concentrations tested by Suber et al. and use systems toxicology analysis of lung tissue to understand molecular events. Sprague Dawley rats were exposed to filtered air (sham), propylene glycol/water (PG/W; 90:10) or a propylene glycol/vegetable glycerin/water (PG/VG/W; 50:40:10) reference. The reference group was added at the high dose to observe any changes that might be associated with a carrier more in line with e-vapor products. Macroscopic examinations and terminal organ weights revealed no observations associated with exposure to PG/W or reference. Food consumption and body weights were unaffected by PG/W or reference when compared to sham. No exposure related alterations were observed in serum chemistry, hematology, coagulation, urinalysis or BALF cytology and clinical chemistry. Although clinical observations of dried red material around the nose in the high dose PG/W group were reported, histopathology showed no nasal hemorrhaging which was previously reported by Suber et al. Non-adverse PG/W and reference related findings of minimal mucous cell hyperplasia were noted in nasal cavity section II. No other exposure-related findings were noted in the primary or recovery necropsies. A systems toxicology analysis on lung tissue showed no statistically significant differentially expressed transcripts or proteins compared to the sham group. The endpoints measured from the PG/W high dose group did not differ significantly from those in the more common carrier PG/VG/W. As anticipated, exposure to PG aerosols was slightly irritating but well tolerated. Accordingly, the highest PG exposure (5 mg/L, 6 hrs/day) was regarded as the NOAEC, corresponding to a PG delivered dose of 1,152 mg/kg/day in rats." @default.
• W3186108779 created "2021-08-02" @default.
• W3186108779 creator A5006402176 @default.
• W3186108779 creator A5008160276 @default.
• W3186108779 creator A5015141831 @default.
• W3186108779 creator A5026967996 @default.
• W3186108779 creator A5043289868 @default.
• W3186108779 creator A5045793906 @default.
• W3186108779 creator A5056753690 @default.
• W3186108779 creator A5057592315 @default.
• W3186108779 creator A5058143169 @default.
• W3186108779 creator A5066115942 @default.
• W3186108779 creator A5087038430 @default.
• W3186108779 creator A5090615601 @default.
• W3186108779 date "2021-01-01" @default.
• W3186108779 modified "2023-09-24" @default.
• W3186108779 title "Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis" @default.
• W3186108779 cites W1967454801 @default.
• W3186108779 cites W1976782957 @default.
• W3186108779 cites W1989560160 @default.
• W3186108779 cites W1992433800 @default.
• W3186108779 cites W1997707189 @default.
• W3186108779 cites W2001566188 @default.
• W3186108779 cites W2001575919 @default.
• W3186108779 cites W2005216394 @default.
• W3186108779 cites W2008375915 @default.
• W3186108779 cites W2009123865 @default.
• W3186108779 cites W2024106803 @default.
• W3186108779 cites W2035356097 @default.
• W3186108779 cites W2057682847 @default.
• W3186108779 cites W2061969001 @default.
• W3186108779 cites W2069309433 @default.
• W3186108779 cites W2081098333 @default.
• W3186108779 cites W2085355530 @default.
• W3186108779 cites W2095509093 @default.
• W3186108779 cites W2110065044 @default.
• W3186108779 cites W2112442607 @default.
• W3186108779 cites W2113878188 @default.
• W3186108779 cites W2122598723 @default.
• W3186108779 cites W2135827569 @default.
• W3186108779 cites W2160697532 @default.
• W3186108779 cites W2163894456 @default.
• W3186108779 cites W2164678484 @default.
• W3186108779 cites W2167816339 @default.
• W3186108779 cites W2169640462 @default.
• W3186108779 cites W2171612862 @default.
• W3186108779 cites W2341622848 @default.
• W3186108779 cites W2473461238 @default.
• W3186108779 cites W2481754535 @default.
• W3186108779 cites W2483514454 @default.
• W3186108779 cites W2751173961 @default.
• W3186108779 cites W2763421867 @default.
• W3186108779 cites W2912208542 @default.
• W3186108779 cites W2921073672 @default.
• W3186108779 cites W3023211482 @default.
• W3186108779 cites W3026667644 @default.
• W3186108779 cites W4211043182 @default.
• W3186108779 doi "https://doi.org/10.1177/23978473211021072" @default.
• W3186108779 hasPublicationYear "2021" @default.
• W3186108779 type Work @default.
• W3186108779 sameAs 3186108779 @default.
• W3186108779 citedByCount "2" @default.
• W3186108779 countsByYear W31861087792023 @default.
• W3186108779 crossrefType "journal-article" @default.
• W3186108779 hasAuthorship W3186108779A5006402176 @default.
• W3186108779 hasAuthorship W3186108779A5008160276 @default.
• W3186108779 hasAuthorship W3186108779A5015141831 @default.
• W3186108779 hasAuthorship W3186108779A5026967996 @default.
• W3186108779 hasAuthorship W3186108779A5043289868 @default.
• W3186108779 hasAuthorship W3186108779A5045793906 @default.
• W3186108779 hasAuthorship W3186108779A5056753690 @default.
• W3186108779 hasAuthorship W3186108779A5057592315 @default.
• W3186108779 hasAuthorship W3186108779A5058143169 @default.
• W3186108779 hasAuthorship W3186108779A5066115942 @default.
• W3186108779 hasAuthorship W3186108779A5087038430 @default.
• W3186108779 hasAuthorship W3186108779A5090615601 @default.
• W3186108779 hasBestOaLocation W31861087791 @default.
• W3186108779 hasConcept C126322002 @default.
• W3186108779 hasConcept C142724271 @default.
• W3186108779 hasConcept C185592680 @default.
• W3186108779 hasConcept C2776954882 @default.
• W3186108779 hasConcept C2777495288 @default.
• W3186108779 hasConcept C2777714996 @default.
• W3186108779 hasConcept C2779225474 @default.
• W3186108779 hasConcept C2780026642 @default.
• W3186108779 hasConcept C29730261 @default.
• W3186108779 hasConcept C33070731 @default.
• W3186108779 hasConcept C42219234 @default.
• W3186108779 hasConcept C42407357 @default.
• W3186108779 hasConcept C544855455 @default.
• W3186108779 hasConcept C55493867 @default.
• W3186108779 hasConcept C71924100 @default.
• W3186108779 hasConcept C86803240 @default.
• W3186108779 hasConceptScore W3186108779C126322002 @default.
• W3186108779 hasConceptScore W3186108779C142724271 @default.
• W3186108779 hasConceptScore W3186108779C185592680 @default.
• W3186108779 hasConceptScore W3186108779C2776954882 @default.
• W3186108779 hasConceptScore W3186108779C2777495288 @default.

• next