Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186119642> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3186119642 endingPage "4" @default.
- W3186119642 startingPage "4" @default.
- W3186119642 abstract "Bicuspid aortic valve is the most common congenital heart disease and in approximately 50% of cases it is associated with aneurysms of any or all segments of the aorta. Ascending aortic aneurysm is responsible for 1%-2% of all deaths in industrialized countries and poses a challenge on the growing and aging society. Although aortic aneurysms are generally benign, a progressive increase in their diameter can lead to catastrophic and fatal event of acute aortic dissection and aortic rupture. Comprehensive genetic, molecular and proteomic analyses have increased our understanding of the complex cellular processes and signaling involved in the pathophysiology of ascending aortic aneurysms. To support the two known hypotheses proposed to explain the causality in aneurysm formation, intrinsic factors related to vascular remodeling were further investigated and analyzed in patients with congenital BAV and Marfan Syndrome (MFS). In MFS, mutations are present in the gene encoding for the extracellular matrix protein fibrillin-1, which causes the dysregulation of transforming growth factor-beta signaling. The second hypothesis proposes a weakening of the aortic wall by steady laminar shear stress caused by the malformed BAV. This theory is supported by the asymmetrical extracellular matrix protein expression patterns and vascular smooth muscle cell apoptosis within the proximal BAV aorta, indicating shear stress-induced changes at certain sites." @default.
- W3186119642 created "2021-08-02" @default.
- W3186119642 creator A5007804671 @default.
- W3186119642 date "2021-01-01" @default.
- W3186119642 modified "2023-09-28" @default.
- W3186119642 title "Identification of potential early biomarkers of aortopathy" @default.
- W3186119642 hasPublicationYear "2021" @default.
- W3186119642 type Work @default.
- W3186119642 sameAs 3186119642 @default.
- W3186119642 citedByCount "0" @default.
- W3186119642 crossrefType "journal-article" @default.
- W3186119642 hasAuthorship W3186119642A5007804671 @default.
- W3186119642 hasConcept C126322002 @default.
- W3186119642 hasConcept C141071460 @default.
- W3186119642 hasConcept C164705383 @default.
- W3186119642 hasConcept C189165786 @default.
- W3186119642 hasConcept C2776098176 @default.
- W3186119642 hasConcept C2777323849 @default.
- W3186119642 hasConcept C2778249958 @default.
- W3186119642 hasConcept C2779980429 @default.
- W3186119642 hasConcept C2780561598 @default.
- W3186119642 hasConcept C2780847584 @default.
- W3186119642 hasConcept C2781355080 @default.
- W3186119642 hasConcept C71924100 @default.
- W3186119642 hasConcept C76334062 @default.
- W3186119642 hasConcept C86803240 @default.
- W3186119642 hasConcept C95444343 @default.
- W3186119642 hasConceptScore W3186119642C126322002 @default.
- W3186119642 hasConceptScore W3186119642C141071460 @default.
- W3186119642 hasConceptScore W3186119642C164705383 @default.
- W3186119642 hasConceptScore W3186119642C189165786 @default.
- W3186119642 hasConceptScore W3186119642C2776098176 @default.
- W3186119642 hasConceptScore W3186119642C2777323849 @default.
- W3186119642 hasConceptScore W3186119642C2778249958 @default.
- W3186119642 hasConceptScore W3186119642C2779980429 @default.
- W3186119642 hasConceptScore W3186119642C2780561598 @default.
- W3186119642 hasConceptScore W3186119642C2780847584 @default.
- W3186119642 hasConceptScore W3186119642C2781355080 @default.
- W3186119642 hasConceptScore W3186119642C71924100 @default.
- W3186119642 hasConceptScore W3186119642C76334062 @default.
- W3186119642 hasConceptScore W3186119642C86803240 @default.
- W3186119642 hasConceptScore W3186119642C95444343 @default.
- W3186119642 hasIssue "4" @default.
- W3186119642 hasLocation W31861196421 @default.
- W3186119642 hasOpenAccess W3186119642 @default.
- W3186119642 hasPrimaryLocation W31861196421 @default.
- W3186119642 hasRelatedWork W1529533761 @default.
- W3186119642 hasRelatedWork W1879222445 @default.
- W3186119642 hasRelatedWork W198115119 @default.
- W3186119642 hasRelatedWork W2007699685 @default.
- W3186119642 hasRelatedWork W2110594928 @default.
- W3186119642 hasRelatedWork W2430187835 @default.
- W3186119642 hasRelatedWork W2560174153 @default.
- W3186119642 hasRelatedWork W2572871393 @default.
- W3186119642 hasRelatedWork W2611601602 @default.
- W3186119642 hasRelatedWork W2616926463 @default.
- W3186119642 hasRelatedWork W2768449510 @default.
- W3186119642 hasRelatedWork W2920835647 @default.
- W3186119642 hasRelatedWork W2950057083 @default.
- W3186119642 hasRelatedWork W2990512350 @default.
- W3186119642 hasRelatedWork W3008229330 @default.
- W3186119642 hasRelatedWork W3013454222 @default.
- W3186119642 hasRelatedWork W3013821279 @default.
- W3186119642 hasRelatedWork W3046565590 @default.
- W3186119642 hasRelatedWork W3080775376 @default.
- W3186119642 hasRelatedWork W4225960012 @default.
- W3186119642 hasVolume "2" @default.
- W3186119642 isParatext "false" @default.
- W3186119642 isRetracted "false" @default.
- W3186119642 magId "3186119642" @default.
- W3186119642 workType "article" @default.