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- W3186124893 endingPage "35355" @default.
- W3186124893 startingPage "35342" @default.
- W3186124893 abstract "Growth-factor-free bone regeneration remains a challenge in craniofacial engineering. Here, we engineered an osteogenic niche composed of a commercially modified alginate hydrogel and whitlockite microparticles (WHMPs), which impart tunable physicochemical properties that can direct osteogenesis of human gingival mesenchymal stem cells (GMSCs). Our in vitro studies demonstrate that WHMPs induce osteogenesis of GMSCs more effectively than previously demonstrated hydroxyapatite microparticles (HApMPs). Alginate–WHMP hydrogels showed higher elasticity without any adverse effects on the viability of the encapsulated GMSCs. Moreover, the alginate–WHMP hydrogels upregulate the mitogen-activated protein kinase (MAPK) pathway, which in turn orchestrates several osteogenic markers, such as RUNX2 and OCN, in the encapsulated GMSCs. Concurrent coculture studies with human osteoclasts demonstrate that GMSCs encapsulated in alginate–WHMP hydrogels downregulate osteoclastic activity, potentially due to release of Mg2+ ions from the WHMPs along with secretion of osteoprotegerin from the GMSCs. In vivo studies demonstrated that the GMSCs encapsulated in our osteogenic niche were able to promote bone repair in calvarial defects in murine models. Altogether, our results confirmed the development of a promising treatment modality for craniofacial bone regeneration based on an injectable growth-factor-free hydrogel delivery system." @default.
- W3186124893 created "2021-08-02" @default.
- W3186124893 creator A5013993870 @default.
- W3186124893 creator A5018129899 @default.
- W3186124893 creator A5019484706 @default.
- W3186124893 creator A5033056518 @default.
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- W3186124893 creator A5078307926 @default.
- W3186124893 creator A5080114259 @default.
- W3186124893 creator A5083348735 @default.
- W3186124893 date "2021-07-23" @default.
- W3186124893 modified "2023-10-18" @default.
- W3186124893 title "Whitlockite-Enabled Hydrogel for Craniofacial Bone Regeneration" @default.
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