Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186132184> ?p ?o ?g. }
- W3186132184 abstract "Abstract Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RNA modification in eukaryotic cells, and the fate of m6A modified transcripts is controlled by m6A RNA binding proteins. m6A modification influences mRNA alternative splicing, stability, translation, and subcellular localization. Intriguingly, recent studies show that m6A RNA methylation could alter the expression of essential autophagy-related ( ATG ) genes and influence the autophagy function. Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases. In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including obesity, heart disease, azoospermatism or oligospermatism, intervertebral disc degeneration, and cancer. The comprehensive understanding of the m6A modification and autophagy interplay may help in interpreting their impact on human diseases and may aid in devising future therapeutic strategies." @default.
- W3186132184 created "2021-08-02" @default.
- W3186132184 creator A5004444798 @default.
- W3186132184 creator A5018892762 @default.
- W3186132184 creator A5023888306 @default.
- W3186132184 creator A5026554334 @default.
- W3186132184 creator A5031702003 @default.
- W3186132184 creator A5081424689 @default.
- W3186132184 creator A5087944559 @default.
- W3186132184 date "2021-07-27" @default.
- W3186132184 modified "2023-10-06" @default.
- W3186132184 title "Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases" @default.
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