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- W3186136925 endingPage "669" @default.
- W3186136925 startingPage "669" @default.
- W3186136925 abstract "Oxaliplatin (OXA) is a platinum compound primarily used in the treatment of gastrointestinal cancer. OXA-induced peripheral neurotoxicity (OXAIPN) is the major non-hematological dose-limiting toxicity of OXA-based chemotherapy and includes acute transient neurotoxic effects that appear soon after OXA infusion, and chronic non-length dependent sensory neuronopathy symmetrically affecting both upper and lower limbs in a stocking-and-glove distribution. No effective strategy has been established to reverse or treat OXAIPN. Thus, it is necessary to early predict the occurrence of OXAIPN during treatment and possibly modify the OXA-based regimen in patients at high risk as an early diagnosis and intervention may slow down neuropathy progression. However, identifying which patients are more likely to develop OXAIPN is clinically challenging. Several objective and measurable early biomarkers for OXAIPN prediction have been described in recent years, becoming useful for informing clinical decisions about treatment. The purpose of this review is to critically review data on currently available or promising predictors of OXAIPN. Neurological monitoring, according to predictive factors for increased risk of OXAIPN, would allow clinicians to personalize treatment, by monitoring at-risk patients more closely and guide clinicians towards better counseling of patients about neurotoxicity effects of OXA." @default.
- W3186136925 created "2021-08-02" @default.
- W3186136925 creator A5004472044 @default.
- W3186136925 creator A5005001615 @default.
- W3186136925 creator A5010024808 @default.
- W3186136925 creator A5033186152 @default.
- W3186136925 date "2021-07-16" @default.
- W3186136925 modified "2023-10-06" @default.
- W3186136925 title "Predictive Biomarkers of Oxaliplatin-Induced Peripheral Neurotoxicity" @default.
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