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- W3186149674 endingPage "R244" @default.
- W3186149674 startingPage "R236" @default.
- W3186149674 abstract "Methodological advances over the last three decades have led to a profound transformation in our understanding of the genetic origins of neuropsychiatric disorders. This is exemplified by the study of autism spectrum disorders (ASDs) for which microarrays, whole exome sequencing and whole genome sequencing have yielded over a hundred causal loci. Genome-wide association studies in ASD have also been fruitful, identifying 5 genome-wide significant loci thus far and demonstrating a substantial role for polygenic inherited risk. Approaches rooted in systems biology and functional genomics have increasingly placed genes implicated by risk variants into biological context. Genetic risk affects a finite group of cell-types and biological processes, converging primarily on early stages of brain development (though, the expression of many risk genes persists through childhood). Coupled with advances in stem cell-based human in vitro model systems, these findings provide a basis for developing mechanistic models of disease pathophysiology." @default.
- W3186149674 created "2021-08-02" @default.
- W3186149674 creator A5018481303 @default.
- W3186149674 creator A5063990046 @default.
- W3186149674 date "2021-07-27" @default.
- W3186149674 modified "2023-09-26" @default.
- W3186149674 title "Three decades of ASD genetics: building a foundation for neurobiological understanding and treatment" @default.
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