FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186159340> ?p ?o ?g. }

• W3186159340 endingPage "e0254344" @default.
• W3186159340 startingPage "e0254344" @default.
• W3186159340 abstract "Transcriptome changes can be expected in survivors after lethal irradiation. We aimed to characterize these in males and females and after different cytokine treatments 60 days after irradiation.Male and female rhesus macaques (n = 142) received a whole-body exposure with 700 cGy, from which 60 animals survived. Peripheral whole blood was drawn pre-exposure and before sacrificing the surviving animals after 60 days.We evaluated gene expression in a three-phase study design. Phase I was a whole-genome screening (NGS) for mRNAs using five pre- and post-exposure RNA samples from both sexes (n = 20). Differential gene expression (DGE) was calculated between samples of survivors and pre-exposure samples (reference), separately for males and females. 1,243 up- and down-regulated genes were identified with 30-50% more deregulated genes in females. 37 candidate mRNAs were chosen for qRT-PCR validation in phase II using the remaining samples (n = 117). Altogether 17 genes showed (borderline) significant (t-test) DGE in groups of untreated or treated animals. Nine genes (CD248, EDAR, FAM19A5, GAL3ST4, GCNT4, HBG2/1, LRRN1, NOG, SYT14) remained with significant changes and were detected in at least 50% of samples per group. Panther analysis revealed an overlap between both sexes, related to the WNT signaling pathway, cell adhesion and immunological functions. For phase III, we validated the nine genes with candidate genes (n = 32) from an earlier conducted study on male baboons. Altogether 14 out of 41 genes showed a concordantly DGE across both species in a bilateral comparison.Sixty days after radiation exposure, we identified (1) sex and cytokine treatment independent transcriptional changes, (2) females with almost twice as much deregulated genes appeared more radio-responsive than males, (3) Panther analysis revealed an association with immunological processes and WNT pathway for both sexes." @default.
• W3186159340 created "2021-08-02" @default.
• W3186159340 creator A5002766476 @default.
• W3186159340 creator A5007644263 @default.
• W3186159340 creator A5026092196 @default.
• W3186159340 creator A5028516114 @default.
• W3186159340 creator A5048706787 @default.
• W3186159340 creator A5050275493 @default.
• W3186159340 creator A5051784102 @default.
• W3186159340 creator A5063892887 @default.
• W3186159340 creator A5068991790 @default.
• W3186159340 creator A5070280595 @default.
• W3186159340 date "2021-07-21" @default.
• W3186159340 modified "2023-10-10" @default.
• W3186159340 title "Gene expression changes in male and female rhesus macaque 60 days after irradiation" @default.
• W3186159340 cites W1484334610 @default.
• W3186159340 cites W1969464492 @default.
• W3186159340 cites W1975742121 @default.
• W3186159340 cites W1985153638 @default.
• W3186159340 cites W1992028388 @default.
• W3186159340 cites W2009337571 @default.
• W3186159340 cites W2022437563 @default.
• W3186159340 cites W2029804030 @default.
• W3186159340 cites W2040228556 @default.
• W3186159340 cites W2044434022 @default.
• W3186159340 cites W2059382724 @default.
• W3186159340 cites W2066617715 @default.
• W3186159340 cites W2075566021 @default.
• W3186159340 cites W2080870494 @default.
• W3186159340 cites W2107830839 @default.
• W3186159340 cites W2117609242 @default.
• W3186159340 cites W2146865145 @default.
• W3186159340 cites W2345241533 @default.
• W3186159340 cites W2461990711 @default.
• W3186159340 cites W2784530964 @default.
• W3186159340 cites W2793008795 @default.
• W3186159340 cites W2900044275 @default.
• W3186159340 cites W2991703276 @default.
• W3186159340 cites W3011658558 @default.
• W3186159340 doi "https://doi.org/10.1371/journal.pone.0254344" @default.
• W3186159340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8294544" @default.
• W3186159340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34288924" @default.
• W3186159340 hasPublicationYear "2021" @default.
• W3186159340 type Work @default.
• W3186159340 sameAs 3186159340 @default.
• W3186159340 citedByCount "1" @default.
• W3186159340 countsByYear W31861593402022 @default.
• W3186159340 crossrefType "journal-article" @default.
• W3186159340 hasAuthorship W3186159340A5002766476 @default.
• W3186159340 hasAuthorship W3186159340A5007644263 @default.
• W3186159340 hasAuthorship W3186159340A5026092196 @default.
• W3186159340 hasAuthorship W3186159340A5028516114 @default.
• W3186159340 hasAuthorship W3186159340A5048706787 @default.
• W3186159340 hasAuthorship W3186159340A5050275493 @default.
• W3186159340 hasAuthorship W3186159340A5051784102 @default.
• W3186159340 hasAuthorship W3186159340A5063892887 @default.
• W3186159340 hasAuthorship W3186159340A5068991790 @default.
• W3186159340 hasAuthorship W3186159340A5070280595 @default.
• W3186159340 hasBestOaLocation W31861593401 @default.
• W3186159340 hasConcept C104317684 @default.
• W3186159340 hasConcept C137620995 @default.
• W3186159340 hasConcept C150194340 @default.
• W3186159340 hasConcept C151730666 @default.
• W3186159340 hasConcept C162317418 @default.
• W3186159340 hasConcept C16685009 @default.
• W3186159340 hasConcept C18431079 @default.
• W3186159340 hasConcept C2778950215 @default.
• W3186159340 hasConcept C2779175743 @default.
• W3186159340 hasConcept C42407357 @default.
• W3186159340 hasConcept C54355233 @default.
• W3186159340 hasConcept C69991583 @default.
• W3186159340 hasConcept C71924100 @default.
• W3186159340 hasConcept C86803240 @default.
• W3186159340 hasConceptScore W3186159340C104317684 @default.
• W3186159340 hasConceptScore W3186159340C137620995 @default.
• W3186159340 hasConceptScore W3186159340C150194340 @default.
• W3186159340 hasConceptScore W3186159340C151730666 @default.
• W3186159340 hasConceptScore W3186159340C162317418 @default.
• W3186159340 hasConceptScore W3186159340C16685009 @default.
• W3186159340 hasConceptScore W3186159340C18431079 @default.
• W3186159340 hasConceptScore W3186159340C2778950215 @default.
• W3186159340 hasConceptScore W3186159340C2779175743 @default.
• W3186159340 hasConceptScore W3186159340C42407357 @default.
• W3186159340 hasConceptScore W3186159340C54355233 @default.
• W3186159340 hasConceptScore W3186159340C69991583 @default.
• W3186159340 hasConceptScore W3186159340C71924100 @default.
• W3186159340 hasConceptScore W3186159340C86803240 @default.
• W3186159340 hasFunder F4320333299 @default.
• W3186159340 hasIssue "7" @default.
• W3186159340 hasLocation W31861593401 @default.
• W3186159340 hasLocation W31861593402 @default.
• W3186159340 hasLocation W31861593403 @default.
• W3186159340 hasOpenAccess W3186159340 @default.
• W3186159340 hasPrimaryLocation W31861593401 @default.
• W3186159340 hasRelatedWork W1971124177 @default.
• W3186159340 hasRelatedWork W1985562003 @default.
• W3186159340 hasRelatedWork W2144348650 @default.
• W3186159340 hasRelatedWork W2563598809 @default.

• next