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- W3186171475 abstract "Caffeine citrate is the drug of choice for the pharmacological treatment of apnea of prematurity. Factors such as maturity and genetic variation contribute to the interindividual variability in the clinical response to caffeine therapy in preterm infants, making the optimal dose administered controversial. Moreover, the necessity for therapeutic drug monitoring (TDM) of caffeine is still worth discussing due to the need to achieve the desired target concentrations as well as concerns about the safety of higher doses. Therefore, we reviewed the pharmacokinetic profile of caffeine in preterm infants, evidence of the safety and efficacy of different doses of caffeine, therapeutic concentration ranges of caffeine and impact of genetic variability on caffeine therapy. Whereas the safety and efficacy of standard-dose caffeine have been demonstrated, evidence for the safety of higher administered doses is insufficient. Thus, preterm infants who lack clinical response to standard-dose caffeine therapy are of interest for TDM when dose optimization is performed. Polymorphisms in pharmacodynamics-related genes, but not in pharmacokinetics-related genes, have a significant impact on the interindividual variability in clinical response to caffeine therapy. For preterm infants lacking clinical response, how to develop individualized medication regimens for caffeine remains to be explored." @default.
- W3186171475 created "2021-08-02" @default.
- W3186171475 creator A5021979312 @default.
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- W3186171475 creator A5091472243 @default.
- W3186171475 date "2021-07-26" @default.
- W3186171475 modified "2023-10-16" @default.
- W3186171475 title "Caffeine for the Pharmacological Treatment of Apnea of Prematurity in the NICU: Dose Selection Conundrum, Therapeutic Drug Monitoring and Genetic Factors" @default.
- W3186171475 cites W133433531 @default.
- W3186171475 cites W135619738 @default.
- W3186171475 cites W1558746539 @default.
- W3186171475 cites W167251272 @default.
- W3186171475 cites W1891699888 @default.
- W3186171475 cites W1957034755 @default.
- W3186171475 cites W1967112573 @default.
- W3186171475 cites W1968221669 @default.
- W3186171475 cites W1970036717 @default.
- W3186171475 cites W1971777629 @default.
- W3186171475 cites W1972200239 @default.
- W3186171475 cites W1975391500 @default.
- W3186171475 cites W1975906543 @default.
- W3186171475 cites W1977510411 @default.
- W3186171475 cites W1980476299 @default.
- W3186171475 cites W1981437859 @default.
- W3186171475 cites W199127806 @default.
- W3186171475 cites W1991814069 @default.
- W3186171475 cites W2000093553 @default.
- W3186171475 cites W2001013152 @default.
- W3186171475 cites W2001420919 @default.
- W3186171475 cites W2003866367 @default.
- W3186171475 cites W2007801259 @default.
- W3186171475 cites W2012307596 @default.
- W3186171475 cites W2015679604 @default.
- W3186171475 cites W2016108754 @default.
- W3186171475 cites W2018358374 @default.
- W3186171475 cites W2020803142 @default.
- W3186171475 cites W2026311352 @default.
- W3186171475 cites W2026368503 @default.
- W3186171475 cites W2027837397 @default.
- W3186171475 cites W2030956223 @default.
- W3186171475 cites W2033693083 @default.
- W3186171475 cites W2047855828 @default.
- W3186171475 cites W2049224179 @default.
- W3186171475 cites W2053058340 @default.
- W3186171475 cites W2058460698 @default.
- W3186171475 cites W2058530997 @default.
- W3186171475 cites W2063283365 @default.
- W3186171475 cites W2067088801 @default.
- W3186171475 cites W2068108752 @default.
- W3186171475 cites W2068847386 @default.
- W3186171475 cites W2068861236 @default.
- W3186171475 cites W2069390811 @default.
- W3186171475 cites W2073239074 @default.
- W3186171475 cites W2073632755 @default.
- W3186171475 cites W2079488969 @default.
- W3186171475 cites W2080037849 @default.
- W3186171475 cites W2081373368 @default.
- W3186171475 cites W2089052896 @default.
- W3186171475 cites W2090267724 @default.
- W3186171475 cites W2090629603 @default.
- W3186171475 cites W2091978651 @default.
- W3186171475 cites W2092469024 @default.
- W3186171475 cites W2093780574 @default.
- W3186171475 cites W2096312125 @default.
- W3186171475 cites W2100336330 @default.
- W3186171475 cites W2114235313 @default.
- W3186171475 cites W2119429678 @default.
- W3186171475 cites W2122527560 @default.
- W3186171475 cites W2123141619 @default.
- W3186171475 cites W2127559364 @default.
- W3186171475 cites W2130249957 @default.
- W3186171475 cites W2130355470 @default.
- W3186171475 cites W2130853041 @default.
- W3186171475 cites W2133998876 @default.
- W3186171475 cites W2141858745 @default.
- W3186171475 cites W2149702700 @default.
- W3186171475 cites W2159615203 @default.
- W3186171475 cites W2168129634 @default.
- W3186171475 cites W2182691695 @default.
- W3186171475 cites W2185037608 @default.
- W3186171475 cites W2217219734 @default.
- W3186171475 cites W2321741145 @default.
- W3186171475 cites W2325270688 @default.
- W3186171475 cites W2334707178 @default.
- W3186171475 cites W2343294511 @default.
- W3186171475 cites W2346031311 @default.
- W3186171475 cites W2433618972 @default.
- W3186171475 cites W2486713628 @default.
- W3186171475 cites W2508025527 @default.
- W3186171475 cites W2509584581 @default.
- W3186171475 cites W2570580099 @default.
- W3186171475 cites W2591453457 @default.
- W3186171475 cites W2601622814 @default.
- W3186171475 cites W2609228496 @default.