FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186172985> ?p ?o ?g. }

• W3186172985 abstract "Abstract Low-coverage or shallow whole genome sequencing (sWGS) approaches can efficiently detect somatic copy number aberrations (SCNAs) at low cost. This is clinically important for many cancers, in particular cancers with severe chromosomal instability (CIN) that frequently lack actionable point mutations and are characterised by poor disease outcome. Absolute copy number (ACN), measured in DNA copies per cancer cell, is required for meaningful comparisons between copy number states, but is challenging to estimate and in practice often requires manual curation. Using a total of 60 cancer cell lines, 148 patient-derived xenograft (PDX) and 142 clinical tissue samples, we evaluate the performance of available tools for obtaining ACN from sWGS. We provide a validated and refined tool called Rascal ( r elative to a bsolute copy number scal ing) that provides improved fitting algorithms and enables interactive visualisation of copy number profiles. These approaches are highly applicable to both pre-clinical and translational research studies on SCNA-driven cancers and provide more robust ACN fits from sWGS data than currently available tools." @default.
• W3186172985 created "2021-08-02" @default.
• W3186172985 creator A5034230450 @default.
• W3186172985 creator A5035293802 @default.
• W3186172985 creator A5045303423 @default.
• W3186172985 creator A5048069780 @default.
• W3186172985 creator A5056049358 @default.
• W3186172985 creator A5061145531 @default.
• W3186172985 creator A5080863062 @default.
• W3186172985 creator A5083151857 @default.
• W3186172985 creator A5089224477 @default.
• W3186172985 date "2021-07-20" @default.
• W3186172985 modified "2023-10-17" @default.
• W3186172985 title "Absolute copy number fitting from shallow whole genome sequencing data" @default.
• W3186172985 cites W1484187172 @default.
• W3186172985 cites W1903523058 @default.
• W3186172985 cites W1915710460 @default.
• W3186172985 cites W1986241711 @default.
• W3186172985 cites W1986850011 @default.
• W3186172985 cites W2005895632 @default.
• W3186172985 cites W2006288875 @default.
• W3186172985 cites W2016661249 @default.
• W3186172985 cites W2040182688 @default.
• W3186172985 cites W2043398720 @default.
• W3186172985 cites W2045387875 @default.
• W3186172985 cites W2055177190 @default.
• W3186172985 cites W2059300459 @default.
• W3186172985 cites W2090144921 @default.
• W3186172985 cites W2096283457 @default.
• W3186172985 cites W2096746187 @default.
• W3186172985 cites W2108643617 @default.
• W3186172985 cites W2117692326 @default.
• W3186172985 cites W2118071133 @default.
• W3186172985 cites W2120869188 @default.
• W3186172985 cites W2123696077 @default.
• W3186172985 cites W2125636389 @default.
• W3186172985 cites W2126087169 @default.
• W3186172985 cites W2140888103 @default.
• W3186172985 cites W2153056550 @default.
• W3186172985 cites W2170490448 @default.
• W3186172985 cites W2205086967 @default.
• W3186172985 cites W2205207487 @default.
• W3186172985 cites W2264731267 @default.
• W3186172985 cites W2412469771 @default.
• W3186172985 cites W2480324413 @default.
• W3186172985 cites W2553574650 @default.
• W3186172985 cites W2570401594 @default.
• W3186172985 cites W2738100725 @default.
• W3186172985 cites W2781895613 @default.
• W3186172985 cites W2801763724 @default.
• W3186172985 cites W2885874790 @default.
• W3186172985 cites W2893209354 @default.
• W3186172985 cites W2907260934 @default.
• W3186172985 cites W2924124844 @default.
• W3186172985 cites W2950993016 @default.
• W3186172985 cites W2951144513 @default.
• W3186172985 cites W2953270703 @default.
• W3186172985 cites W2981602595 @default.
• W3186172985 cites W3004647847 @default.
• W3186172985 cites W3007172120 @default.
• W3186172985 cites W3011898120 @default.
• W3186172985 cites W3033879864 @default.
• W3186172985 cites W3044254950 @default.
• W3186172985 cites W3082714866 @default.
• W3186172985 cites W3083497411 @default.
• W3186172985 cites W3120392574 @default.
• W3186172985 cites W3127905008 @default.
• W3186172985 cites W3136308181 @default.
• W3186172985 cites W4253079290 @default.
• W3186172985 doi "https://doi.org/10.1101/2021.07.19.452658" @default.
• W3186172985 hasPublicationYear "2021" @default.
• W3186172985 type Work @default.
• W3186172985 sameAs 3186172985 @default.
• W3186172985 citedByCount "7" @default.
• W3186172985 countsByYear W31861729852022 @default.
• W3186172985 countsByYear W31861729852023 @default.
• W3186172985 crossrefType "posted-content" @default.
• W3186172985 hasAuthorship W3186172985A5034230450 @default.
• W3186172985 hasAuthorship W3186172985A5035293802 @default.
• W3186172985 hasAuthorship W3186172985A5045303423 @default.
• W3186172985 hasAuthorship W3186172985A5048069780 @default.
• W3186172985 hasAuthorship W3186172985A5056049358 @default.
• W3186172985 hasAuthorship W3186172985A5061145531 @default.
• W3186172985 hasAuthorship W3186172985A5080863062 @default.
• W3186172985 hasAuthorship W3186172985A5083151857 @default.
• W3186172985 hasAuthorship W3186172985A5089224477 @default.
• W3186172985 hasBestOaLocation W31861729851 @default.
• W3186172985 hasConcept C104317684 @default.
• W3186172985 hasConcept C120821319 @default.
• W3186172985 hasConcept C121608353 @default.
• W3186172985 hasConcept C141231307 @default.
• W3186172985 hasConcept C24432333 @default.
• W3186172985 hasConcept C2994372470 @default.
• W3186172985 hasConcept C41008148 @default.
• W3186172985 hasConcept C51679486 @default.
• W3186172985 hasConcept C54355233 @default.
• W3186172985 hasConcept C552990157 @default.
• W3186172985 hasConcept C70721500 @default.
• W3186172985 hasConcept C86803240 @default.
• W3186172985 hasConcept C96232424 @default.

• next