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- W3186181848 abstract "Paraspeckles are membraneless organelles formed through liquid-liquid phase separation and consist of multiple proteins and RNAs, including NONO, SFPQ, and NEAT1. The role of paraspeckles and the component NONO in hematopoiesis remains unknown. In this study, we show histone modifier ASXL1 is involved in paraspeckle formation. ASXL1 forms phase-separated droplets, upregulates NEAT1 expression, and increases NONO-NEAT1 interactions through the C-terminal intrinsically disordered region (IDR). In contrast, a pathogenic ASXL mutant (ASXL1-MT) lacking IDR does not support the interaction of paraspeckle components. Furthermore, paraspeckles are disrupted and Nono localization is abnormal in the cytoplasm of hematopoietic stem and progenitor cells (HSPCs) derived from ASXL1-MT knockin mice. Nono depletion and the forced expression of cytoplasmic NONO impair the repopulating potential of HSPCs, as does ASXL1-MT. Our study indicates a link between ASXL1 and paraspeckle components in the maintenance of normal hematopoiesis." @default.
- W3186181848 created "2021-08-02" @default.
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- W3186181848 date "2021-08-01" @default.
- W3186181848 modified "2023-10-18" @default.
- W3186181848 title "A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells" @default.
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- W3186181848 cites W1979635179 @default.
- W3186181848 cites W1981300029 @default.
- W3186181848 cites W1984986640 @default.
- W3186181848 cites W1992320498 @default.
- W3186181848 cites W1999813105 @default.
- W3186181848 cites W2002785400 @default.
- W3186181848 cites W2008900314 @default.
- W3186181848 cites W2011026333 @default.
- W3186181848 cites W2028207201 @default.
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- W3186181848 cites W2048865995 @default.
- W3186181848 cites W2051282896 @default.
- W3186181848 cites W2066231767 @default.
- W3186181848 cites W2068592712 @default.
- W3186181848 cites W2088815589 @default.
- W3186181848 cites W2091204895 @default.
- W3186181848 cites W2103015533 @default.
- W3186181848 cites W2108196925 @default.
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- W3186181848 cites W2123810432 @default.
- W3186181848 cites W2124231394 @default.
- W3186181848 cites W2131445177 @default.
- W3186181848 cites W2157658519 @default.
- W3186181848 cites W2160858975 @default.
- W3186181848 cites W2165581033 @default.
- W3186181848 cites W2167279371 @default.
- W3186181848 cites W2167898988 @default.
- W3186181848 cites W2221817458 @default.
- W3186181848 cites W2258553021 @default.
- W3186181848 cites W2272704264 @default.
- W3186181848 cites W2300545781 @default.
- W3186181848 cites W2340295145 @default.
- W3186181848 cites W2425405879 @default.
- W3186181848 cites W2529260723 @default.
- W3186181848 cites W2538905100 @default.
- W3186181848 cites W2576359799 @default.
- W3186181848 cites W2578906464 @default.
- W3186181848 cites W2599443582 @default.
- W3186181848 cites W2606011875 @default.
- W3186181848 cites W2619932938 @default.
- W3186181848 cites W2739653892 @default.
- W3186181848 cites W2749532133 @default.
- W3186181848 cites W2767788589 @default.
- W3186181848 cites W2770992827 @default.
- W3186181848 cites W2781409644 @default.
- W3186181848 cites W2790176103 @default.
- W3186181848 cites W2790994954 @default.
- W3186181848 cites W2797367925 @default.
- W3186181848 cites W2806884808 @default.
- W3186181848 cites W2808919170 @default.
- W3186181848 cites W2811305839 @default.
- W3186181848 cites W2820089296 @default.
- W3186181848 cites W2884082692 @default.
- W3186181848 cites W2897081817 @default.
- W3186181848 cites W2903402165 @default.
- W3186181848 cites W2928779381 @default.
- W3186181848 cites W2931966052 @default.
- W3186181848 cites W2950374603 @default.
- W3186181848 cites W2950464315 @default.
- W3186181848 cites W2964849163 @default.
- W3186181848 cites W2980184617 @default.
- W3186181848 cites W2982291252 @default.
- W3186181848 cites W3087999205 @default.
- W3186181848 cites W3138213655 @default.
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- W3186181848 doi "https://doi.org/10.1016/j.celrep.2021.109576" @default.