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• W3186184440 endingPage "7995" @default.
• W3186184440 startingPage "7995" @default.
• W3186184440 abstract "This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents’ background information and personal exposure to traffic sources were obtained from questionnaires distributed to randomly selected school children. Real-time monitoring instruments were used for 6-h measurements of PM10, PM2.5, PM1, NO2, SO2, O3, CO, and total volatile organic compounds (TVOC). Meanwhile, 24-h measurements of PM2.5-bound black carbon (BC) were performed using air sampling pumps. The salivary histone H3 level was captured using an enzyme-linked immunosorbent assay (ELISA). HT schools had significantly higher PM10, PM2.5, PM1, BC, NO2, SO2, O3, CO, and TVOC than LT schools, all at p < 0.001. Children in the HT area were more likely to get higher histone H3 levels (z = −5.13). There were positive weak correlations between histone H3 level and concentrations of NO2 (r = 0.37), CO (r = 0.36), PM1 (r = 0.35), PM2.5 (r = 0.34), SO2 (r = 0.34), PM10 (r = 0.33), O3 (r = 0.33), TVOC (r = 0.25), and BC (r = 0.19). Overall, this study proposes the possible role of histone H3 modification in interpreting the effects of TRAP exposure via non-genotoxic mechanisms." @default.
• W3186184440 created "2021-08-02" @default.
• W3186184440 creator A5017737402 @default.
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• W3186184440 date "2021-07-28" @default.
• W3186184440 modified "2023-09-27" @default.
• W3186184440 title "The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children" @default.
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• W3186184440 doi "https://doi.org/10.3390/ijerph18157995" @default.
• W3186184440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8345469" @default.
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• W3186184440 hasPublicationYear "2021" @default.
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