Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186192705> ?p ?o ?g. }
- W3186192705 abstract "Abstract K v 1.1 containing potassium channels play crucial roles towards dampening neuronal excitability. Mice lacking K v 1.1 subunits ( Kcna1 −/− ) display recurrent spontaneous seizures and often exhibit sudden unexpected death. Seizures in Kcna1 −/− mice resemble those in well-characterized models of temporal lobe epilepsy known to involve limbic brain regions and spontaneous seizures result in enhanced cFos expression and neuronal death in the amygdala. Yet, the functional alterations leading to amygdala hyperexcitability have not been identified. In this study, we used Kcna1 −/− mice to examine the contributions of K v 1.1 subunits to excitability in neuronal subtypes from basolateral (BLA) and central lateral (CeL) amygdala known to exhibit distinct firing patterns. We also analyzed synaptic transmission properties in an amygdala local circuit predicted to be involved in epilepsy-related comorbidities. Our data implicate K v 1.1 subunits in controlling spontaneous excitatory synaptic activity in BLA pyramidal neurons. In the CeL, K v 1.1 loss enhances intrinsic excitability and impairs inhibitory synaptic transmission, notably resulting in dysfunction of feed-forward inhibition, a critical mechanism for controlling spike timing. Overall, we find inhibitory control of CeL interneurons is reduced in Kcna1 −/− mice suggesting that basal inhibitory network functioning is less able to prevent recurrent hyperexcitation related to seizures." @default.
- W3186192705 created "2021-08-02" @default.
- W3186192705 creator A5018834365 @default.
- W3186192705 creator A5025356114 @default.
- W3186192705 creator A5048817987 @default.
- W3186192705 creator A5074355895 @default.
- W3186192705 date "2021-07-26" @default.
- W3186192705 modified "2023-09-29" @default.
- W3186192705 title "Kv1.1 channels mediate network excitability and feed-forward inhibition in local amygdala circuits" @default.
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