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• W3186193892 abstract "Abstract Osteosarcoma is a highly aggressive malignant tumor, which most commonly occurs in children and adolescents. This study aims to reveal that hypoxia promotes the invasion of osteosarcoma cells by up-regulating the expression of NUSAP1. The expression of HIF-1α and NUSAP1 was significantly up-regulated in MG63 cells cultured in hypoxia for 6–36 h. Furthermore, hypoxia induced the migration and invasion of MG63 cells and regulated the level of E-cad, N-cad, Vimentin, Snail, Slug, MMP2, and MMP9 proteins. Importantly, knockdown of NUSAP1 inhibited hypoxia-induced cell migration and invasion. In the hypoxia microenvironment, the addition of HIF-1α inhibitor or the transfection of siRNA specifically targeting HIF-1α significantly reduced the expression of HIF-1α and NUSAP1 and markedly inhibited the migration and invasion of MG63 cells under the hypoxia microenvironment. In conclusion, hypoxia induced the expression of NUSAP1 in a HIF-1α-dependent manner, stimulating the migration and invasion of MG63 cells." @default.
• W3186193892 created "2021-08-02" @default.
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• W3186193892 date "2021-01-01" @default.
• W3186193892 modified "2023-10-17" @default.
• W3186193892 title "Hypoxia stimulates the migration and invasion of osteosarcoma via up-regulating the NUSAP1 expression" @default.
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• W3186193892 doi "https://doi.org/10.1515/med-2020-0180" @default.
• W3186193892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8299310" @default.
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