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• W3186202362 endingPage "103193" @default.
• W3186202362 startingPage "103193" @default.
• W3186202362 abstract "The nonhomologous DNA end joining pathway is required for repair of most double-strand breaks in the mammalian genome. Here we use a purified biochemical NHEJ system to compare the joining of free DNA with recombinant mononucleosomal and dinucleosomal substrates to investigate ligation and local DNA end resection. We find that the nucleosomal state permits ligation in a manner dependent on the presence of free DNA flanking the nucleosome core particle. Local resection at DNA ends by the Artemis:DNA-PKcs nuclease complex is completely suppressed in all mononucleosome substrates regardless of flanking DNA up to a length of 14 bp. Like mononucleosomes, dinucleosomes lacking flanking free DNA are not joined. Therefore, the nucleosomal state imposes severe constraints on NHEJ nuclease and ligase activities." @default.
• W3186202362 created "2021-08-02" @default.
• W3186202362 creator A5003639857 @default.
• W3186202362 creator A5061294690 @default.
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• W3186202362 date "2021-10-01" @default.
• W3186202362 modified "2023-10-03" @default.
• W3186202362 title "Nonhomologous DNA end joining of nucleosomal substrates in a purified system" @default.
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• W3186202362 doi "https://doi.org/10.1016/j.dnarep.2021.103193" @default.
• W3186202362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8435023" @default.
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• W3186202362 hasPublicationYear "2021" @default.
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