FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186228749> ?p ?o ?g. }

• W3186228749 endingPage "608" @default.
• W3186228749 startingPage "607" @default.
• W3186228749 abstract "With great interest, we read the article published by Doberne and colleagues1Doberne J.W. Jawitz O.K. Raman V. Bryner B.S. Schroder J.N. Milano C.A. Heart transplantation survival outcomes of HIV positive and negative recipients.Ann Thorac Surg. 2021; 111: 1465-1471Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar regarding heart transplantation outcomes in HIV-positive (HIV+) and HIV-negative (HIV–) recipients. We commend the authors for their important work reporting no differences in survival among these 2 patient populations. Propensity score matching and Cox proportional hazards modeling both supported the conclusion that HIV+ recipient status was not an independent predictor of posttransplant mortality. Additionally, HIV+ recipients experienced higher rates of acute rejection and treatment with antirejection medications before discharge. Although 5-year posttransplant outcomes suggest similar rates of survival among HIV+ and HIV– recipients, the elevated risk of acute rejection in the former should be highlighted. Regarding this patient population, treatment with more potent immunosuppressants like high-dose corticosteroids has shown efficacy in treating acute organ rejection.2Anil Kumar M.S. Sierka D.R. Damask A.M. et al.Safety and success of kidney transplantation and concomitant immunosuppression in HIV-positive patients.Kidney Int. 2005; 67: 1622-1629Abstract Full Text Full Text PDF PubMed Scopus (190) Google Scholar This raises a critical issue that should be emphasized as an additional contraindication to transplanting HIV+ recipients, especially while there remains a risk for coronavirus disease 2019 (COVID-19). Recent studies have demonstrated diminished levels of spike-specific antibodies in immunosuppressed individuals who received the COVID-19 vaccine.3Grupper A. Rabinowich L. Schwartz D. et al.Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus.Am J Transplant. 2021; 21: 2719-2726Crossref PubMed Scopus (260) Google Scholar This is concerning for 2 reasons: 1) protection from COVID-19 is positively correlated with neutralizing antibody titers4Mercado N.B. Zahn R. Wegmann F. et al.Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.Nature. 2020; 586: 583-588Crossref PubMed Scopus (580) Google Scholar and 2) mass vaccination has prompted full reopening and lifting of mask mandates despite underwhelming vaccination rates in several regions across the United States. Immunosuppressed individuals are subsequently placed at greater risk for morbidity and mortality with exposure to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). It should be noted that a comprehensive pretransplant evaluation ensures up-to-date vaccination status before initiating immunosuppressive therapy. Nevertheless, given the emergence of several variants of concern capable of escaping polyclonal antibody responses,5Hoffmann M. Arora P. Groß R. et al.SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.Cell. 2021; 184: 2384-2393.e12Abstract Full Text Full Text PDF PubMed Scopus (594) Google Scholar enhanced COVID-19 disease continues to be a threat to the immunosuppressed. Whether COVID-19-associated mortality risk influences long-term survival in HIV+ transplant recipients remains to be determined. However, we urge the transplant community to consider these factors when evaluating management strategies for their patients before transplantation. Heart Transplantation Survival Outcomes of HIV Positive and Negative RecipientsThe Annals of Thoracic SurgeryVol. 111Issue 5PreviewIn the era of antiretroviral therapy, HIV-positive patients have reduced mortality from HIV infection and increased morbidity from end-stage heart failure. The number of HIV-positive heart transplantation recipients remains scant. Long-term survival has not been rigorously studied. We compared survival outcomes of heart transplantation in HIV-positive recipients with those of HIV-negative recipients. Full-Text PDF" @default.
• W3186228749 created "2021-08-02" @default.
• W3186228749 creator A5021115713 @default.
• W3186228749 creator A5079847443 @default.
• W3186228749 creator A5090346613 @default.
• W3186228749 date "2022-08-01" @default.
• W3186228749 modified "2023-10-18" @default.
• W3186228749 title "Immunosuppression in HIV-Positive Heart Transplant Recipients During the Post–COVID-19 Era" @default.
• W3186228749 cites W2111051799 @default.
• W3186228749 cites W3045734160 @default.
• W3186228749 cites W3085954324 @default.
• W3186228749 cites W3138734145 @default.
• W3186228749 cites W3155756133 @default.
• W3186228749 doi "https://doi.org/10.1016/j.athoracsur.2021.06.052" @default.
• W3186228749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8302816" @default.
• W3186228749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34310920" @default.
• W3186228749 hasPublicationYear "2022" @default.
• W3186228749 type Work @default.
• W3186228749 sameAs 3186228749 @default.
• W3186228749 citedByCount "0" @default.
• W3186228749 crossrefType "journal-article" @default.
• W3186228749 hasAuthorship W3186228749A5021115713 @default.
• W3186228749 hasAuthorship W3186228749A5079847443 @default.
• W3186228749 hasAuthorship W3186228749A5090346613 @default.
• W3186228749 hasBestOaLocation W31862287491 @default.
• W3186228749 hasConcept C126322002 @default.
• W3186228749 hasConcept C142724271 @default.
• W3186228749 hasConcept C151730666 @default.
• W3186228749 hasConcept C203014093 @default.
• W3186228749 hasConcept C204787440 @default.
• W3186228749 hasConcept C2776494729 @default.
• W3186228749 hasConcept C2778849806 @default.
• W3186228749 hasConcept C2779196057 @default.
• W3186228749 hasConcept C2779343474 @default.
• W3186228749 hasConcept C2779384505 @default.
• W3186228749 hasConcept C2780252810 @default.
• W3186228749 hasConcept C2780727368 @default.
• W3186228749 hasConcept C2908647359 @default.
• W3186228749 hasConcept C2911091166 @default.
• W3186228749 hasConcept C3013748606 @default.
• W3186228749 hasConcept C71924100 @default.
• W3186228749 hasConcept C86803240 @default.
• W3186228749 hasConcept C99454951 @default.
• W3186228749 hasConceptScore W3186228749C126322002 @default.
• W3186228749 hasConceptScore W3186228749C142724271 @default.
• W3186228749 hasConceptScore W3186228749C151730666 @default.
• W3186228749 hasConceptScore W3186228749C203014093 @default.
• W3186228749 hasConceptScore W3186228749C204787440 @default.
• W3186228749 hasConceptScore W3186228749C2776494729 @default.
• W3186228749 hasConceptScore W3186228749C2778849806 @default.
• W3186228749 hasConceptScore W3186228749C2779196057 @default.
• W3186228749 hasConceptScore W3186228749C2779343474 @default.
• W3186228749 hasConceptScore W3186228749C2779384505 @default.
• W3186228749 hasConceptScore W3186228749C2780252810 @default.
• W3186228749 hasConceptScore W3186228749C2780727368 @default.
• W3186228749 hasConceptScore W3186228749C2908647359 @default.
• W3186228749 hasConceptScore W3186228749C2911091166 @default.
• W3186228749 hasConceptScore W3186228749C3013748606 @default.
• W3186228749 hasConceptScore W3186228749C71924100 @default.
• W3186228749 hasConceptScore W3186228749C86803240 @default.
• W3186228749 hasConceptScore W3186228749C99454951 @default.
• W3186228749 hasIssue "2" @default.
• W3186228749 hasLocation W31862287491 @default.
• W3186228749 hasLocation W31862287492 @default.
• W3186228749 hasLocation W31862287493 @default.
• W3186228749 hasOpenAccess W3186228749 @default.
• W3186228749 hasPrimaryLocation W31862287491 @default.
• W3186228749 hasRelatedWork W167180346 @default.
• W3186228749 hasRelatedWork W1973527051 @default.
• W3186228749 hasRelatedWork W2013225817 @default.
• W3186228749 hasRelatedWork W2022804919 @default.
• W3186228749 hasRelatedWork W2023216655 @default.
• W3186228749 hasRelatedWork W2057600598 @default.
• W3186228749 hasRelatedWork W2154174321 @default.
• W3186228749 hasRelatedWork W2404983030 @default.
• W3186228749 hasRelatedWork W2413178576 @default.
• W3186228749 hasRelatedWork W4206463297 @default.
• W3186228749 hasVolume "114" @default.
• W3186228749 isParatext "false" @default.
• W3186228749 isRetracted "false" @default.
• W3186228749 magId "3186228749" @default.
• W3186228749 workType "article" @default.