FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186229437> ?p ?o ?g. }

• W3186229437 abstract "QPX7728 is a novel β-lactamase inhibitor (BLI) that belongs to a class of cyclic boronates. The first member of this class, vaborbactam, is a BLI in the recently approved Vabomere (meropenem-vaborbactam). In this paper we provide the overview of the biochemical, structural and microbiological studies that were recently conducted with QPX7728. We show that QPX7728 is an ultra-broad-spectrum β-lactamase inhibitor with the broadest spectrum of inhibition reported to date in a single BLI molecule; in addition to potent inhibition of clinically important serine β-lactamases, including Class A and D carbapenemases from Enterobacterales and notably, diverse Class D carbapenemases from Acinetobacter, it also inhibits many metallo β-lactamases. Importantly, it is minimally affected by general intrinsic resistance mechanisms such as efflux and porin mutations that impede entry of drugs into gram-negative bacteria. QPX7728 combinations with several intravenous (IV) β-lactam antibiotics shows broad coverage of Enterobacterales, Acinetobacter baumannii and Pseudomonas aeruginosa , including strains that are resistant to other IV β-lactam-BLI combinations, e.g., ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam and imipenem-relebactam that were recently approved for clinical use. Based on studies with P. aeruginosa , different partner β-lactams in combination with QPX7728 may be optimal for the coverage of susceptible organisms. This provides microbiological justification for a stand-alone BLI product for co-administration with different β-lactams. QPX7728 can also be delivered orally; thus, its ultra-broad β-lactamase inhibition spectrum and other features could be also applied to oral QPX7728-based combination products. Clinical development of QPX7728 has been initiated." @default.
• W3186229437 created "2021-08-02" @default.
• W3186229437 creator A5001524626 @default.
• W3186229437 creator A5023544619 @default.
• W3186229437 creator A5036883082 @default.
• W3186229437 creator A5062011810 @default.
• W3186229437 creator A5063736715 @default.
• W3186229437 creator A5065586040 @default.
• W3186229437 creator A5069292762 @default.
• W3186229437 creator A5070322806 @default.
• W3186229437 creator A5071771766 @default.
• W3186229437 date "2021-07-05" @default.
• W3186229437 modified "2023-10-18" @default.
• W3186229437 title "QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics" @default.
• W3186229437 cites W1787970496 @default.
• W3186229437 cites W1968310807 @default.
• W3186229437 cites W1996764065 @default.
• W3186229437 cites W1999979510 @default.
• W3186229437 cites W2015984063 @default.
• W3186229437 cites W2022174414 @default.
• W3186229437 cites W2041114499 @default.
• W3186229437 cites W2075287054 @default.
• W3186229437 cites W2091219913 @default.
• W3186229437 cites W2095685393 @default.
• W3186229437 cites W2119724838 @default.
• W3186229437 cites W2120061656 @default.
• W3186229437 cites W2125787660 @default.
• W3186229437 cites W2131120652 @default.
• W3186229437 cites W2135113667 @default.
• W3186229437 cites W2143045972 @default.
• W3186229437 cites W2152683133 @default.
• W3186229437 cites W2157262071 @default.
• W3186229437 cites W2160027305 @default.
• W3186229437 cites W2226714711 @default.
• W3186229437 cites W2507943823 @default.
• W3186229437 cites W2735601417 @default.
• W3186229437 cites W2739039423 @default.
• W3186229437 cites W2749240848 @default.
• W3186229437 cites W2766376787 @default.
• W3186229437 cites W2778650888 @default.
• W3186229437 cites W2796172180 @default.
• W3186229437 cites W2797827228 @default.
• W3186229437 cites W2807660315 @default.
• W3186229437 cites W2884524290 @default.
• W3186229437 cites W2886918301 @default.
• W3186229437 cites W2909686608 @default.
• W3186229437 cites W2913867355 @default.
• W3186229437 cites W2918608884 @default.
• W3186229437 cites W2944613386 @default.
• W3186229437 cites W2949061168 @default.
• W3186229437 cites W2972837536 @default.
• W3186229437 cites W2972950834 @default.
• W3186229437 cites W2995512584 @default.
• W3186229437 cites W3000242169 @default.
• W3186229437 cites W3005470867 @default.
• W3186229437 cites W3011996393 @default.
• W3186229437 cites W3023468510 @default.
• W3186229437 cites W3047109398 @default.
• W3186229437 cites W3048688177 @default.
• W3186229437 cites W3080137116 @default.
• W3186229437 cites W3088048783 @default.
• W3186229437 cites W3143398375 @default.
• W3186229437 doi "https://doi.org/10.3389/fmicb.2021.697180" @default.
• W3186229437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8287861" @default.
• W3186229437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34290688" @default.
• W3186229437 hasPublicationYear "2021" @default.
• W3186229437 type Work @default.
• W3186229437 sameAs 3186229437 @default.
• W3186229437 citedByCount "20" @default.
• W3186229437 countsByYear W31862294372022 @default.
• W3186229437 countsByYear W31862294372023 @default.
• W3186229437 crossrefType "journal-article" @default.
• W3186229437 hasAuthorship W3186229437A5001524626 @default.
• W3186229437 hasAuthorship W3186229437A5023544619 @default.
• W3186229437 hasAuthorship W3186229437A5036883082 @default.
• W3186229437 hasAuthorship W3186229437A5062011810 @default.
• W3186229437 hasAuthorship W3186229437A5063736715 @default.
• W3186229437 hasAuthorship W3186229437A5065586040 @default.
• W3186229437 hasAuthorship W3186229437A5069292762 @default.
• W3186229437 hasAuthorship W3186229437A5070322806 @default.
• W3186229437 hasAuthorship W3186229437A5071771766 @default.
• W3186229437 hasBestOaLocation W31862294371 @default.
• W3186229437 hasConcept C104317684 @default.
• W3186229437 hasConcept C185592680 @default.
• W3186229437 hasConcept C21951064 @default.
• W3186229437 hasConcept C2776315533 @default.
• W3186229437 hasConcept C2776968632 @default.
• W3186229437 hasConcept C2777058267 @default.
• W3186229437 hasConcept C2777406300 @default.
• W3186229437 hasConcept C2777637488 @default.
• W3186229437 hasConcept C2779375183 @default.
• W3186229437 hasConcept C2779631663 @default.
• W3186229437 hasConcept C2910641391 @default.
• W3186229437 hasConcept C3020442560 @default.
• W3186229437 hasConcept C501593827 @default.
• W3186229437 hasConcept C523546767 @default.
• W3186229437 hasConcept C54355233 @default.
• W3186229437 hasConcept C547475151 @default.
• W3186229437 hasConcept C71924100 @default.
• W3186229437 hasConcept C86803240 @default.

• next