FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186247198> ?p ?o ?g. }

• W3186247198 abstract "Background: Nosocomial meningitis with multidrug-resistant (MDR) or extensively drug-resistant (XDR) Acinetobacter baumannii is a life-threatening complication in neurosurgery. Treatment of these infections is challenging because of poor penetration of the available antibiotics into the cerebrospinal fluid (CSF). Intrathecal (ITH) or intraventricular (IVT) administration of antibiotics is increasingly used as the last treatment option against MDR/XDR Gram-negative bacteria meningitis not responding to intravenous (IV) regimens. However, pertinent data in pediatric patients is scarce. Case Presentation: A 14-year-old male patient developed meningitis from an MDR strain of A. baumannii following endoscopic endonasal resection of craniopharyngioma. Despite a combination therapy involving IV tigecycline, we observed clinical and bacteriologic failure. The patient was then successfully treated with an ITH and IV polymyxin B-based combination. Quantification of tigecycline and polymyxin B in CSF was performed with two-dimensional high-performance liquid chromatography (2D-HPLC) and HDLC coupled with tandem mass spectrometry (HPLC-MS/MS), respectively. Adverse drug reactions (neurotoxicity and skin hyperpigmentation), probably induced by polymyxin B, were acceptable and reversible. Conclusions: The case illustrates ITH and IV Polymyxin B-based combination is an optimal therapeutic option against MDR A. baumannii meningitis in this pediatric patient. In the future, real-time PK/PD data obtained from patients during ITH/IVT polymyxin B therapy should be required to optimize polymyxin use with maximal efficacy and minimal adverse effects." @default.
• W3186247198 created "2021-08-02" @default.
• W3186247198 creator A5002385901 @default.
• W3186247198 creator A5007855609 @default.
• W3186247198 creator A5008614366 @default.
• W3186247198 creator A5030872551 @default.
• W3186247198 creator A5048667512 @default.
• W3186247198 creator A5049756016 @default.
• W3186247198 creator A5053547620 @default.
• W3186247198 creator A5063958787 @default.
• W3186247198 creator A5076570332 @default.
• W3186247198 date "2021-07-27" @default.
• W3186247198 modified "2023-09-24" @default.
• W3186247198 title "Successful Treatment With Intrathecal and Intravenous Polymyxin B-Based Combination Against MDR Acinetobacter baumannii Meningitis in Pediatric Patient: A Case Report" @default.
• W3186247198 cites W1602597014 @default.
• W3186247198 cites W2004618470 @default.
• W3186247198 cites W2044488507 @default.
• W3186247198 cites W2061301070 @default.
• W3186247198 cites W2068572420 @default.
• W3186247198 cites W2100827124 @default.
• W3186247198 cites W2102732904 @default.
• W3186247198 cites W2148134051 @default.
• W3186247198 cites W2151963302 @default.
• W3186247198 cites W2162268639 @default.
• W3186247198 cites W2235093984 @default.
• W3186247198 cites W2418781961 @default.
• W3186247198 cites W2461551182 @default.
• W3186247198 cites W2508381207 @default.
• W3186247198 cites W2563455121 @default.
• W3186247198 cites W2567023149 @default.
• W3186247198 cites W2591551956 @default.
• W3186247198 cites W2593868023 @default.
• W3186247198 cites W2626233324 @default.
• W3186247198 cites W2736633473 @default.
• W3186247198 cites W2760678255 @default.
• W3186247198 cites W2801694583 @default.
• W3186247198 cites W2810963831 @default.
• W3186247198 cites W2885001104 @default.
• W3186247198 cites W2886627908 @default.
• W3186247198 cites W2897002667 @default.
• W3186247198 cites W2908698595 @default.
• W3186247198 cites W2911566892 @default.
• W3186247198 cites W2913131218 @default.
• W3186247198 cites W2966535838 @default.
• W3186247198 cites W2979481109 @default.
• W3186247198 cites W3131147063 @default.
• W3186247198 cites W4242255643 @default.
• W3186247198 doi "https://doi.org/10.3389/fped.2021.564991" @default.
• W3186247198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8353103" @default.
• W3186247198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34386463" @default.
• W3186247198 hasPublicationYear "2021" @default.
• W3186247198 type Work @default.
• W3186247198 sameAs 3186247198 @default.
• W3186247198 citedByCount "6" @default.
• W3186247198 countsByYear W31862471982022 @default.
• W3186247198 crossrefType "journal-article" @default.
• W3186247198 hasAuthorship W3186247198A5002385901 @default.
• W3186247198 hasAuthorship W3186247198A5007855609 @default.
• W3186247198 hasAuthorship W3186247198A5008614366 @default.
• W3186247198 hasAuthorship W3186247198A5030872551 @default.
• W3186247198 hasAuthorship W3186247198A5048667512 @default.
• W3186247198 hasAuthorship W3186247198A5049756016 @default.
• W3186247198 hasAuthorship W3186247198A5053547620 @default.
• W3186247198 hasAuthorship W3186247198A5063958787 @default.
• W3186247198 hasAuthorship W3186247198A5076570332 @default.
• W3186247198 hasBestOaLocation W31862471981 @default.
• W3186247198 hasConcept C126322002 @default.
• W3186247198 hasConcept C141071460 @default.
• W3186247198 hasConcept C197934379 @default.
• W3186247198 hasConcept C2776315533 @default.
• W3186247198 hasConcept C2777027569 @default.
• W3186247198 hasConcept C2777637488 @default.
• W3186247198 hasConcept C2779259085 @default.
• W3186247198 hasConcept C2780026444 @default.
• W3186247198 hasConcept C2780675486 @default.
• W3186247198 hasConcept C2781026528 @default.
• W3186247198 hasConcept C501593827 @default.
• W3186247198 hasConcept C523546767 @default.
• W3186247198 hasConcept C54355233 @default.
• W3186247198 hasConcept C71924100 @default.
• W3186247198 hasConcept C86803240 @default.
• W3186247198 hasConcept C89423630 @default.
• W3186247198 hasConceptScore W3186247198C126322002 @default.
• W3186247198 hasConceptScore W3186247198C141071460 @default.
• W3186247198 hasConceptScore W3186247198C197934379 @default.
• W3186247198 hasConceptScore W3186247198C2776315533 @default.
• W3186247198 hasConceptScore W3186247198C2777027569 @default.
• W3186247198 hasConceptScore W3186247198C2777637488 @default.
• W3186247198 hasConceptScore W3186247198C2779259085 @default.
• W3186247198 hasConceptScore W3186247198C2780026444 @default.
• W3186247198 hasConceptScore W3186247198C2780675486 @default.
• W3186247198 hasConceptScore W3186247198C2781026528 @default.
• W3186247198 hasConceptScore W3186247198C501593827 @default.
• W3186247198 hasConceptScore W3186247198C523546767 @default.
• W3186247198 hasConceptScore W3186247198C54355233 @default.
• W3186247198 hasConceptScore W3186247198C71924100 @default.
• W3186247198 hasConceptScore W3186247198C86803240 @default.
• W3186247198 hasConceptScore W3186247198C89423630 @default.
• W3186247198 hasLocation W31862471981 @default.
• W3186247198 hasLocation W31862471982 @default.

• next