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• W3186255320 startingPage "1184" @default.
• W3186255320 abstract "Fabry disease is a hereditary genetic defect resulting in reduced activity of the enzyme α-galactosidase-A and the accumulation of globotriaosylceramide (Gb3) in body fluids and cells. Gb3 accumulation was especially reported for the vascular endothelium in several organs.Three Fabry disease patients were screened using a micro-RNA screen. An in vitro approach in human endothelial cells was used to determine miRNA regulation by Gb3.In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. We demonstrate in vitro in endothelial cells that Gb3 induced activation of NF-κB and activated downstream targets. In addition, NF-κB activity directly reduced let-7a and let-7d miRNA expression as inhibiting NF-kB nuclear entry abolished the Gb3 effects.We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients." @default.
• W3186255320 created "2021-08-02" @default.
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• W3186255320 date "2021-07-30" @default.
• W3186255320 modified "2023-10-18" @default.
• W3186255320 title "MiRNA Let-7a and Let-7d Are Induced by Globotriaosylceramide via NF-kB Activation in Fabry Disease" @default.
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• W3186255320 doi "https://doi.org/10.3390/genes12081184" @default.
• W3186255320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8394417" @default.
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